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The guanine nucleotide exchange factor Rin-like is a repressor for renal uric acid excretion in human and mouse

Key takeaways

Researchers found a gene called RINL that helps kidneys remove uric acid. When this gene does not work right, uric acid builds up in the blood. This study used human cells and mice to show how the gene works. It was not done in people yet, but it points to a new target for drugs.

Who did this work

Changshun Han (Xiamen University) · Chengyong He (Xiamen University) · Weiping Hu (First Affiliated Hospital of Xiamen University) · Zhiyuan Chen (Xiamen University) · Xiaoyan Ding (Xiamen University) · Lingxiao Ye (Xiamen University) · Sihao Zhu (Xiamen University) · Lin Zhong (Xiamen University) · Shuni Zhuang (Xiamen University) · Tianyun Peng (Xiamen University) · Zixuan Li (Xiamen University) · Pan He (Xiamen University)

Source

Article · OpenAlex, CKD works · 2026-09-23
https://doi.org/10.1126/scitranslmed.aed1866