← brief for 2026-09-24 · Regeneration & devices

Disturbed mitochondrial energy production in methylmalonic aciduria is cell-type and variant-dependent

Preprint D Not peer reviewed Preclinical

Key takeaways

This study looked at cells from people with a rare genetic condition called methylmalonic aciduria. It found that the cells' energy factories, called mitochondria, do not work right. This was done in a lab, not in people yet. It helps explain why kidneys can get damaged in this condition.

Source

Preprint · bioRxiv cell biology (kidney-filtered downstream) · 2026-09-24
https://www.biorxiv.org/content/10.64898/2026.09.23.753738v1?rss=1