Kidney research, 2026-10-14

Red blood cell distribution width is an indicator of physiological dysregulation and reveals the relationship between biomarkers and health status in hemodialysis patients

This study looked at blood test data from 1,216 people on dialysis. It tracked changes over a 9-year period. The team found that a marker called RDW shows how unstable a person's...

The APOL1 protective M1 modifier occurs exclusively with the KIK protein haplotype to suppress channel conductance

This study used cells to test a specific gene change called M1. The M1 change is linked to a lower risk of kidney disease. The team found that M1 only works when it sits on a...

Characterization of the neoprotein MUC1-fs in patient-derived cells with ADTKD-MUC1

This study looked at a specific genetic form of kidney disease called ADTKD-MUC1. Researchers grew cells from the urine of several patients in the lab. They studied how a faulty...

Association between blood urea nitrogen-to-albumin ratio and kidney stones: A cross-sectional study based on NHANES

This study looked at a blood test called the BAR to see if it predicts kidney stones. It used data from US health surveys from 2007 to 2020. The researchers found a link between...

Hepatitis E virus immunoglobulin G seropositivity and kidney dysfunction among United States adults

This study checked if past exposure to the Hepatitis E virus is linked to kidney problems. It used data from US health surveys between 2009 and 2023. The researchers looked at...

Urinary collagen type I degradation products as common fibrosis biomarkers in chronic diseases

This study looked for a common sign of scarring in the urine of people with chronic diseases. It included patients with liver, kidney, and heart problems. The goal was to find a...

Spatially resolved transcriptomics of glomerular diseases

This study used a new lab technique to look at kidney tissue from 59 people. It focused on three different types of kidney disease. The researchers found that these diseases share...

Prevalence of Enteric Hyperoxaluria in Crohn's Disease, Cystic Fibrosis, and After Bariatric Surgery: A Systematic Review

This review looked at how common a certain type of kidney stone risk is in people with gut diseases. It covered conditions like Crohn's disease and cystic fibrosis. The researchers...

Efsubaglutide Alfa: A Comprehensive Pharmacological Review.

This is a review of a new long-acting drug for diabetes and weight. It explains how the drug works in the body. It looks at how long it stays in the system and how it might...

Pharmacotherapy for MASLD/MASH: approved therapies, drug repurposing, and emerging mechanism-based candidates.

This is a review of drugs for fatty liver disease. It looks at new medicines and how they might help people with liver and kidney problems. It summarizes what is known so far. It...

An Observational Study, Called FINEXPLORER, to Learn More About How Well Finerenone Works in Adults in Spain With Chronic Kidney Disease (CKD) Linked to Type 2 Diabetes, by Looking at Changes in a CKD Risk Score

This is a study that is starting in Spain. It will watch how a drug called finerenone works in people with kidney disease and type 2 diabetes. It will track their risk of getting...

Cardiorenal Syndrome: From Hemodynamic and Humoral Pathophysiology to New Frontiers in Modulation and Enabling Therapy—Part 1

This is a review of how heart and kidney problems affect each other. It explains the body's systems that get stuck in a loop. It does not report new trial results.

Composite Blood-Count Inflammatory Indices in Diabetic Kidney Disease and Advanced, Largely Dialysis-Dependent Non-Diabetic Chronic Kidney Disease: A Single-Centre, Four-Group Cross-Sectional Study

This study checked if certain blood markers are unique to diabetic kidney disease. It found that these markers are high in many types of kidney disease, not just diabetes. This...

Timing of recurrent acute kidney injury is associated with mortality and chronic kidney disease progression in very elderly patients

This study looked at older adults who had sudden kidney injury. It found that when the injury came back early, it was linked to higher death rates. This shows a link, not proof of...

Case Report: Monotypic IgG1-λ fibrillary glomerulonephritis associated with rheumatoid arthritis

This report describes one 72-year-old woman with joint disease who had a rare kidney condition. Her kidney biopsy showed specific protein deposits. This is a single patient story,...

Dark Urine After Nonfatal Drowning: Rhabdomyolysis-Associated Acute Kidney Injury and Freshwater Aspiration Pneumonia

This story is about one man who had sudden kidney damage after drowning. His muscles broke down and released proteins that hurt his kidneys. This is a single case report, not a...

Blood DNA methylation profiling identifies candidate diabetic kidney disease risk signatures in the PROPHECY Aboriginal Diabetes Study

Researchers looked at blood samples from 95 people to find signs of high risk for kidney disease. They found specific DNA patterns that matched different risk levels. This shows a...

Renal Artery Aneurysms Rarely Rupture, Have a Slow Growth Rate, and Small Aneurysms are Stabilised by Extensive Calcification of the Aneurysm Wall

This study looks at bulges in the kidney's main artery. It suggests these bulges grow slowly and rarely burst. There is no abstract available, so the specific results are not known...

The significance of foot process effacement in renal prognosis and response to treatment in IgA nephropathy

This study examines how kidney tissue looks under a microscope in people with IgA nephropathy. It aims to see if these changes predict how well treatment works. There is no...

Short-term superiority in proteinuria control with exploratory longitudinal trajectories: finerenone-dapagliflozin combination in non-diabetic kidney disease

This study looked at 327 people with kidney disease who do not have diabetes. It found that taking two drugs together helped lower protein in the urine more than taking just one....

Factors associated with KDIGO stage 3 acute kidney injury in pediatric leptospirosis

Edaravone for Potential Mitigation of Oxidative Stress and Inflammation in Kidney Disease

This review looks at a drug called edaravone that fights cell damage. It shows the drug can help in animal models of kidney disease. These results are from animals and cells, not...

Integrating Renal Function, Drug Exposure, and Clinical Outcomes to Personalize Dosing of High-Risk Medications in Chronic Kidney Disease

Supporting data for E2F7 and E2F8 attenuate diabetic kidney disease by suppressing E2F1 induced tubular senescence

This is supporting data for a study on a compound called resveratrol. It shows the compound helped in mice with diabetes. These results are from animals, not people yet.

Emerging roles of apolipoprotein E4 in cerebral small vessel disease-related cognitive impairment: mechanistic insights and therapeutic perspectives

This review looks at how a protein called ApoE4 affects brain health. It focuses on small blood vessel disease in the brain. The authors discuss how this protein may change the...

The Importance of a Constitutional Approach in Hypertension

This article argues that high blood pressure care should be personal. It says doctors should look at a patient's full health history. This includes age, lifestyle, and other health...

Distal Radial Access in Patients With Chronic Kidney Disease: Lessons From the KODRA Registry

Systemic inflammatory response index as an independent predictor of all-cause mortality in patients receiving maintenance hemodialysis: a retrospective cohort study

This study looked at 534 people on dialysis to see if a blood test score could predict who would die. The score, called the systemic inflammatory response index, measures signs of...

Assessing the Impact of Routine Intervention for Perioperative Hyponatremia on Postoperative Outcomes

This study looked at people with low sodium levels before surgery. It checked if treating the low sodium improved their recovery. The study included people with kidney disease. It...

Distal Radial Access in Chronic Kidney Disease: What Should We Measure?

Analysis of Renal Prognostic Factors in Patients with Acute Renal Infarction: A 10-Year Retrospective Study

This study looked at people who had a blood clot block a kidney artery. It found links between certain factors and kidney damage. This shows a link, not proof of cause.

Microbiota-targeted interventions in chronic kidney disease: probiotics, prebiotics, synbiotics, fecal microbiota transplantation, and traditional Chinese medicine

This review looked at how gut health treatments, like probiotics, affect kidney disease. It combined data from many studies to see what works best. It suggests these treatments may...

In-Hospital Outcomes According to Treatment Strategy in NSTEMI Patients Undergoing Coronary Angiography: No Index Revascularization, PCI, or CABG?

This study looked at 1,906 people who had a specific type of heart attack. It compared three treatments: doing nothing, a stent, or bypass surgery. The group that had bypass...

Relationship Between CD44 and Glomerular Filtration Rate in Chronic Kidney Disease

This study looked at a protein called CD44 in urine. It found a link between this protein and how well kidneys filter blood. This shows a link, not proof of cause.

Quinolinic acid contributes to maladaptive kidney injury and acute kidney injury-to-chronic kidney disease transition.

This study looked at a chemical called quinolinic acid in the body. It found that this chemical can make kidney injury worse and turn it into long-term disease. The work was done...

SGLT1/2 inhibitor sotagliflozin, but not SGLT2-selective inhibitor empagliflozin, attenuates platelet activation and thrombosis.

This study compared two diabetes drugs that also protect the heart and kidneys. It found that one drug, sotagliflozin, reduced blood clotting in the test tube. The other drug,...

Kidney Protection from Glucagon-Like Peptide-1 Receptor Agonists: Simply a Result of Weight Loss, or Something Else?

Aldosterone-mineralocorticoid receptor signaling and residual cardiorenal risk in type 2 diabetes.

This review looks at how a hormone called aldosterone affects the heart and kidneys in people with type 2 diabetes. It summarizes what is known so far. It is a review of existing...

Gliflozin-Derived SGLT2 Inhibitors: Recent Advances and Future Perspectives in the Management of Type 2 Diabetes.

This review covers a class of diabetes drugs called SGLT2 inhibitors. It looks at how they work and their effects on the heart and kidneys. It is a summary of past studies, not a...

Glucagon-Like Peptide-1 Receptor Agonist and Gastrointestinal Adverse Effects: A Comprehensive Review.

This review looks at stomach and gut side effects from a class of diabetes and weight loss drugs. It explains why these side effects happen and how to manage them. It is a summary...

Oral Obesity Medicines in the Era of Cardiovascular-Kidney-Metabolic Syndrome (CKM): Beyond Weight Loss Toward Disease Modification.

This review looks at oral weight-loss drugs. It argues these drugs should be judged by how well they protect the heart and kidneys, not just by weight loss. The article summarizes...

Glycemic Outcomes Associated With GLP-1 Receptor Agonist Shortages in Type 2 Diabetes.

This study looked at 177 people with type 2 diabetes. It found that drug shortages led to worse blood sugar control. This shows a link between supply issues and health outcomes,...

Intensive titration for elderly patients with heart failure.

This study followed older adults with heart failure. It tested a plan to quickly adjust their heart medications. The results show a link between this plan and patient outcomes. It...

Epidemiology of Uncontrolled and Treatment‑Resistant Hypertension: A Registry‑Based Observational Study.

This study looked at health records in Sweden. It found that many people with high blood pressure do not reach their target levels. This shows a link between treatment patterns and...

Genetic kidney diseases: Decoding molecular taxonomies to drive precision nephrology and therapeutic innovation.

This review explains how genetic testing helps diagnose kidney disease. It notes that about 10% of chronic kidney disease is caused by a single gene. It summarizes how this changes...

Integrated Analysis of the aKlotho-FGF23-FGFR Genetic Axis Reveals Determinants of Cardiovascular Risk in Chronic Kidney Disease.

This study looked at the genes of 829 people with kidney disease. It found links between certain gene changes and heart risks. This shows a connection, but it is not proof of...

Association between the hemoglobin albumin lymphocyte and platelet score and chronic kidney disease: Insights from patient data and animal models.

This study looked at 25,181 people to see if a blood test score predicts kidney disease. The score uses four common blood markers. It shows a link between the score and kidney...

Creatinine increases have consistent and differential prognostic impact across kidney function.

This study examined patients having major surgery in four countries. It looked at how small rises in a kidney marker affect health. The study shows a link between these changes and...

Effects of Sitagliptin Combined with GTS-21 on Improving Glycemic Control and Diabetic Nephropathy by Anti-Apoptosis in Lepr(db/db) Mice.

This study was done in mice, not people. It tested a combination of two drugs to help with diabetes and kidney damage. The mice were given the drugs for 4 weeks. The study looked...

[Development and validation of a predictive model for high-flow nasal cannula oxygen therapy failure in patients with type I respiratory failure].

This study looked at people in the ICU who needed oxygen therapy. It tried to predict when the therapy would fail. It found certain risk factors that were linked to failure. This...

Acute Kidney Injury Following Whole Cherry Consumption as a Sleep Aid in a Geriatric Patient With Chronic Kidney Disease.

This is a report about one 95-year-old woman with kidney disease. She ate whole cherries every night to help her sleep. Her kidney function dropped sharply for two weeks. When she...

Physical Activity Levels and Lung-Kidney Function in a Cohort of COVID-19 Survivors.

This study looked at people who survived a hospital stay for COVID-19. It checked if being active was linked to better lung and kidney health. It found a link between activity and...

Combined analysis of protein intake and functional capacity in non-elective hospitalization in patients with non-dialysis chronic kidney disease

This study looked at how much protein people with kidney disease eat and how strong they are. It found a link between low protein intake, weak muscles, and more hospital stays....

Effectiveness of mHealth Nutrition Interventions on Nutrition-Related and Clinical Outcomes in Adults with Chronic Kidney Disease: A Systematic Review and Meta-Analysis

This review combined data from many studies on phone apps for diet. It found that these apps can help people with kidney disease follow their food plans. This is a strong type of...

Perception of Cardio-Kidney-Metabolic Risk and Health Literacy in Women: Quantitative and Qualitative Insights into Lifestyle and Prevention

This study surveyed 198 women about their health knowledge and diet. It found a link between understanding health risks and following a healthy diet. This shows a link, not proof...

Diet quality and frailty among older adults with chronic kidney disease

From dietary exposure to organ injury: microbiome-mediated biotransformation of food-chain xenobiotics across the gut–liver–kidney axis

This review looks at how gut bacteria process chemicals from food. It discusses how this affects the liver and kidneys. The authors focus on how these changes can lead to disease....

Feasibility and acceptability of a telehealth-supported physical activity program for children with chronic kidney disease: a pilot mixed methods study.

This small trial tested an online exercise program for kids with kidney disease. It ran for 12 weeks. The study checked if the program was doable and acceptable. It was a pilot...

Trends and disparities in cardiometabolic disease prevalence by physical activity among US adults: NHANES 2007-2018.

This study analyzed data from 26,380 US adults. It found that people who exercise regularly have lower rates of heart and kidney disease. This shows a link, not proof of cause. The...

[Correlation between serum lactate levels and disseminated intravascular coagulation in patients with heat stroke].

This study looked at people with heat stroke. It checked if a certain blood test result was linked to a serious blood clotting problem. It found a link between high lactate levels...

Spatial proteomics identifies altered thick ascending limb cells as drivers of kidney disease through uromodulin retention

This study used a special imaging tool to look at kidney cells. It found that a specific type of cell gets stuck with a protein called uromodulin. This protein usually leaves the...

A review of advances in research on mechanisms inhibiting kidney stone formation from a network pharmacology perspective.

This is a review of research on how to stop kidney stones from forming. It looks at natural products from many different cultures. The review summarizes what is known but does not...

Yishen Xiaoke Formula Delays Renal Fibrosis in Rats with Diabetic Nephropathy by Suppressing the Transforming Growth Factor-Beta 1/Notch Signalling Pathway.

This study tested a traditional Chinese medicine formula in rats. The rats had kidney damage from diabetes. The formula helped slow down scarring in the kidneys. This was done in...

Donor-aware multi-cohort single-cell analysis identifies an LXR-linked tubular cholesterol-handling state in membranous nephropathy with a coordinated five-gene lipid-remodeling signature across renal tumors

This study looked at kidney cells in the lab to understand a disease called membranous nephropathy. It found a specific pattern in how cells handle cholesterol. This work was done...

Glyceraldehyde May Induce the Generation of High-Molecular-Weight Species of HSP90β and Autophagy-Related Proteins and Alter Protein Levels in Human Renal Epithelial Cells

This study tested how a sugar called glyceraldehyde affects kidney cells in a lab. It looked at how the cells handle stress and clean up waste. This work was done in cells, not in...

Annexin A1 contributes to fibroblast activation in kidney fibrosis via regulating YAP-mediated autophagy

This study looked at how a protein called Annexin A1 affects kidney scarring. It used human samples and animal models to test this. The work was done in cells and animals, not in...

Haemodiafiltration, haemofiltration and haemodialysis for adults with kidney failure

This is an updated review of different dialysis methods for people with kidney failure. It compares three types of blood cleaning. There is no new data to read in this record...

Serum cell adhesion molecules (CAMs) NrCAM and P-Cadherin as novel biomarkers in lupus nephritis.

This study looked for new blood markers for lupus nephritis. It found two specific proteins that are higher in people with this condition. This shows a link between these proteins...

Immune checkpoint and matrix remodeling gene polymorphisms predict allograft rejection in kidney transplant recipients: A large single-centre study

This study looks at genes that might predict if a transplanted kidney will be rejected. It aims to help doctors choose better treatments. There are no new results in this record.

Elevations in epidermal growth factor and interleukin-15 may help predict antibody-mediated and cellular-mediated kidney allograft rejection, respectively

This study looks at blood markers that might predict if a transplanted kidney will be rejected. There is no abstract available, so the specific results are not known yet.

Quantification of anti-HLA eplet strength to determine unacceptable antigens: A 3 year follow up from two independent kidney transplant programs

This study tracks transplant patients for three years to see how their bodies react to the new kidney. There is no abstract available, so the specific results are not known yet.

Unanticipated DSAs following renal allograft failure and the lessons learned

This report discusses unexpected antibodies that appear after a transplanted kidney fails. It shares lessons from these cases. There is no abstract available, so the specific...

Implementation of a willing to cross program to expand transplant opportunities for highly sensitized kidney candidates

Timing of renal coordinator referral and risk of unplanned dialysis initiation in advanced chronic kidney disease: a retrospective cohort study.

This study looked at 282 people with advanced kidney disease in Singapore. It checked if getting help from a care coordinator early on reduced the chance of starting dialysis...

Renal Metastases from Extra-Renal Primary Malignancies: A Systematic Review of Clinicopathological Features, Imaging Characteristics, Management, and Outcomes

This is a review of how cancer spreads to the kidneys. It looks at how doctors find and treat these cases. There are no new results in this record.

UCI CKD benchmark: leakage-free re-analysis (code, data and results)

This is a data set and code for testing computer models of kidney disease. It helps researchers check if their models work well. There are no new clinical results for patients.

Incidence and Outcomes of Acute Kidney Injury in Critically Ill Patients: A Retrospective Study at a Tertiary Care Hospital

This study looked at sick people in an intensive care unit in Nepal. It found that sudden kidney injury is common and leads to longer stays and higher death rates. This shows a...

Oral health status and navigation of care among first nations peoples with kidney failure in South Australia

This study looks at dental health and how people get care for kidney failure. It focuses on First Nations peoples in South Australia. There are no new results in this record.

When anatomy and injury collide: Successful management of high-grade injury to pelvic ectopic kidney with review of literature

This report describes one young woman with a kidney in the pelvis. She had a bad injury after a fall. Doctors used surgery to fix the damage. This is a single case, not a large...

Editorial: Management of patients with dialysis dependent chronic kidney disease (DD-CKD)

This is an editorial that introduces a group of studies on dialysis care. It discusses how doctors measure treatment success. It does not report new trial results itself.

Effectiveness of Mobile Health (mHealth) Applications in Chronic Disease Management: Implications for Medical-Surgical Practice

This review looks at how phone apps help people manage long-term health issues. It covers conditions like kidney disease and diabetes. The authors discuss how these tools can...

Emerging Nephrology Nursing: Current & Future roles

This review describes the changing role of nurses in kidney care. It covers how they help with dialysis and transplants. The authors look at future needs in the field. There are no...

Digital home monitoring versus usual outpatient follow-up in chronic kidney disease: cost-effectiveness of the PROKID randomised non-inferiority trial