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Donor-aware multi-cohort single-cell analysis identifies an LXR-linked tubular cholesterol-handling state in membranous nephropathy with a coordinated five-gene lipid-remodeling signature across renal tumors

Article D Peer reviewed Preclinical

Key takeaways

This study looked at kidney cells in the lab to understand a disease called membranous nephropathy. It found a specific pattern in how cells handle cholesterol. This work was done in cells and samples, not in living people yet. It helps scientists understand the disease better.

Who did this work

Yalan Mao (The First People's Hospital of Tianmen) · Ran Li (Xuzhou Medical College) · Bin Li (The First People's Hospital of Tianmen) · Hongfen Pan

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-10-14
https://doi.org/10.3389/fgene.2026.1916595