← brief for 2026-10-14 · Slowing decline

Quinolinic acid contributes to maladaptive kidney injury and acute kidney injury-to-chronic kidney disease transition.

Article D Peer reviewed Preclinical

Key takeaways

This study looked at a chemical called quinolinic acid in the body. It found that this chemical can make kidney injury worse and turn it into long-term disease. The work was done in animals and cells, not people yet. It may help explain why some kidney damage becomes permanent.

Who did this work

Saade MC · Saliba A · Clark AJ · Debnath S · Zhang S · Ragi N · Etzrodt V · Al-Humaidi R · Vu K · Tao Y · Trevino E · Lorenzen AL

Source

Article · PubMed, CKD progression · 2026 Oct 14
https://pubmed.ncbi.nlm.nih.gov/42873891/