← brief for 2026-10-14 · Regeneration & devices

Spatial proteomics identifies altered thick ascending limb cells as drivers of kidney disease through uromodulin retention

Preprint D Not peer reviewed Preclinical

Key takeaways

This study used a special imaging tool to look at kidney cells. It found that a specific type of cell gets stuck with a protein called uromodulin. This protein usually leaves the kidney in urine. When it stays inside the cell, it may drive kidney disease. This was done in cells, not in people yet. It helps explain how kidney damage starts.

Source

Preprint · bioRxiv cell biology (kidney-filtered downstream) · 2026-10-12
https://www.biorxiv.org/content/10.64898/2026.10.09.756985v1?rss=1