Kidney research, 2026-10-10
New data shows Nefecon beats steroids for a common kidney disease.
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A new real-world study found that Nefecon works better than steroids for a common kidney disease.
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A large review found that hidden high blood pressure is very common in people with kidney disease who are not on dialysis.
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A new review found that an oral drug for kidney anemia works well for people on peritoneal dialysis.
Today's news focuses on practical treatment options and common risks. The strongest finding is that Nefecon outperforms steroids for a specific kidney condition. Readers should also note that hidden high blood pressure is a frequent issue for those not on dialysis. Other reports cover anemia treatment and lifestyle factors like yoga and magnesium.
Intercellular GAS6-AXL signaling triggers podocyte cuproptosis in acute kidney injury upstream regulated by CEBPD
This study looks at how kidney cells die during injury. It used cell samples and computer models to find the cause. This is a preclinical study, meaning it was done in cells, not...
Genetic and Epigenetic Aspects of Urate Urolithiasis: The Role of Urate Transporters
This review explains how high uric acid levels can lead to kidney stones and disease. It is an observational study, so it shows a link but not proof of cause. It helps explain why...
Translational Applications of Retinal Biomarkers in Chronic Cardiovascular, Neurological, Metabolic, and Renal Diseases
This review looks at how eye scans can track kidney disease. It explains that doctors can use these scans to check for changes in blood vessels. The article discusses how this tool...
Special Issue “Diagnosis and Monitoring of Kidney Disease: From Biology to Biomarkers”
This is a collection of papers on how to spot and track kidney disease. It is a special issue, not a single study with new results. It covers the background of the field.
Estimating Long-Term Organ Damage Risk in Patients with Congenital Thrombotic Thrombocytopenic Purpura Receiving Recombinant ADAMTS13 Prophylaxis: A Structured Expert Elicitation Study
This paper asks six doctors to guess the risk of organ damage in a rare blood disease. It is a survey of expert opinions, not a test on real patients. There are no new results from...
Comparison of methods for variable selection
This study looked at medical records to find a way to spot poor blood flow in the legs. It focused on people with kidney disease, who are at higher risk. The team checked 992...
A serial mediation analysis of preoperative anemia, postoperative anemia burden, and RBC transfusion on AKI risk in cardiac surgery
This study looked at 44,810 people having heart surgery. It checked if low blood counts before surgery led to kidney injury. The results show a link between low blood counts and...
A Methodologically Robust XGBoost Framework for Balanced Chronic Kidney Disease Prediction
This study built a computer model to predict kidney disease. It focused on making the model fair for all types of patients. The results show the model works well for detection....
Polytrauma survivors requiring kidney replacement therapy during the acute ICU phase: long-term clinical and kidney outcomes
This study followed 62 people who had severe injuries and needed kidney support in the hospital. It looks at their health years later. The results show how kidney function changes...
The Role of the Gut–Kidney Axis in the Progression of Chronic Kidney Disease
This review explains how the bacteria in your gut affect kidney health. It summarizes what we know about this connection. The gut and kidneys talk to each other, and changes in one...
Serotonergic dysregulation: a path to early diagnosis of cardiorenal syndrome
This paper discusses how serotonin levels might help find heart and kidney problems early. Current tests often miss these issues until damage is done. The study suggests serotonin...
Salivary proline-rich proteins are non-canonical serum biomarkers of chronic kidney disease
This study looked at proteins in saliva and blood to find signs of kidney disease. It used mouse models and data from 1,023 people. The results suggest these proteins could be a...
Explainable machine learning for preoperative prediction of acute kidney injury after intertrochanteric fracture surgery in older adults
Researchers built a computer model to predict kidney injury after hip surgery in older adults. They looked at data from 616 patients. The model helps doctors spot high-risk...
Association analysis of IL‑6 polymorphisms and relevant biomarkers in patients with renal failure
This study examined 51 people to see if certain gene changes link to kidney disease. It shows a link, not proof of cause. The group was small, so the results need more testing.
EXPLORING THE ROLE OF SERUM MAGNESIUM IN VASCULAR CALCIFICATION AMONG CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS
This study looked at 82 people on dialysis to see if blood magnesium levels link to hardening of the arteries. It shows a link, not proof of cause. Higher magnesium may be...
Association of pretransfusion platelet count with mortality in patients with sepsis-associated acute kidney injury
This study looked at 1047 people with sepsis and kidney injury. It checked blood platelet levels before transfusion. Lower platelets were linked to higher death risk. It is a large...
Abdominal aortic calcification in patients receiving maintenance haemodialysis: prevalence and associated factors at a tertiary care centre
This study looked at 197 people on dialysis. It checked for hardening of the main belly artery. This is a sign of heart disease. It is a small study that shows a link, not proof of...
Prevalence of Enteric Hyperoxaluria in Crohn's Disease, Cystic Fibrosis, and After Bariatric Surgery: A Systematic Review
This review looked at how often high urine oxalate happens in people with gut diseases. It covered Crohn's disease, cystic fibrosis, and people after weight loss surgery. High...
Gut microbiota‐derived tryptophan metabolite attenuates calcium oxalate nephropathy by suppressing renal tubular cell apoptosis through the AhR – SOCS3 – STAT1 axis
This study used mice to test a compound called indole-3-propionic acid (IPA). It comes from gut bacteria and is made from tryptophan. Giving mice IPA by mouth reduced kidney...
Association of uric acid-to-albumin ratio with diabetic kidney disease
Researchers looked at 3,984 people to see if a blood marker called the uric acid-to-albumin ratio is linked to kidney damage. They found that higher levels of this marker were...
Renoprotective vs. Antihypertensive Dosing of Renin–Angiotensin System Inhibitors in Chronic Kidney Disease: Analysis of Summary of Product Characteristics of Medicinal Products Authorized in Poland
This study checked the official drug labels for blood pressure medicines in Poland. It looked at how the labels suggest dosing for people with kidney disease. It is a review of...
Rituximab with low-dose glucocorticoids for treating refractory membranous nephropathy: a prospective single-center cohort study
This is a new study about a drug mix for a hard-to-treat kidney condition. There is no abstract, so we do not have the results yet. It is a study that is starting or planned.
Understanding the Evidence Gaps in the Epidemiology and Burden of Lupus Nephritis and Membranous Nephropathy: A Targeted Literature Review
This review looks at what we do not know about two kidney diseases. There is no abstract, so we do not have the specific findings yet. It is a review that is starting or planned.
A novel age-norm–capped baseline serum creatinine approach for acute kidney injury diagnosis in critically Ill children: a retrospective cohort study
This study looks at a new way to diagnose sudden kidney injury in children. There is no abstract, so we do not have the results yet. It is a study that is starting or planned.
Time-stratified prognostic factors for poor renal outcomes in childhood-onset lupus nephritis: a systematic review and meta-analysis
This review looks at risk factors for bad kidney outcomes in children with lupus. There is no abstract, so we do not have the results yet. It is a review that is starting or...
Cardiac remodeling and subclinical myocardial dysfunction in patients with chronic kidney disease undergoing maintenance hemodialysis: a retrospective echocardiographic study
This study looks at heart changes in people on dialysis. There is no abstract, so we do not have the results yet. It is a study that is starting or planned.
Anti-PLA2R antibody levels and clinical risk factors for predicting relapse in primary membranous nephropathy
This study looks at blood tests to predict if a kidney disease will come back. There is no abstract, so we do not have the results yet. It is a study that is starting or planned.
Probiotic-Postbiotic Synergy and Microbial Co-Culture Strategies for Hyperuricemia: Gut Microbiota and Functional Food Perspectives
This review looks at how gut bacteria and probiotics might help lower high uric acid levels. It discusses existing research but does not report new trial results.
Nutritional intake on dialysis and non-dialysis days and the effect of intradialytic food provision among hemodialysis patients, a single-center study
This study looked at 60 people on dialysis. It checked how much they ate on dialysis days and other days. Many had low muscle mass or frailty. It is a small study that shows a...
Caloric restriction attenuates age-related liver and kidney alterations in mice: Histological evidence.
Mice that ate less showed less scarring in their kidneys and livers as they aged. This was done in animals, not people yet. It suggests that eating less might help slow age-related...
Epithelial PDGF-C Contributes to Crescentic Glomerulonephritis and FSGS in Part via Activation of Parietal Epithelial Cells
Researchers found that a protein called PDGF-C helps drive kidney scarring in two common kidney diseases. This work was done in mice, not people yet. It shows a possible target for...
Senescence-Associated Transcriptome Reversal Prioritizes Repurposing Candidates for Diabetic Kidney Disease: A Computational Study
This study used computer models to find drugs for diabetic kidney disease. It looked at how cells age and die. It is a computer study, not a test in people. It suggests new drugs...
Supplemental Material for: Italian Cooperative HemoAdsorption Study for Relief of Uremic Symptoms (ICHARUS): Study Protocol for a Prospective, Multicenter, Real-World Registry
This is the plan for a new study on a dialysis add-on called hemoadsorption. The study is starting, so there are no results yet. It aims to see if this extra step helps with...
Case Report: Late-onset BK polyomavirus-associated nephropathy with encephalitis, antibody-mediated rejection, and atypical hemolytic uremic syndrome: a rare overlap causing allograft dysfunction, therapeutic challenges, and multidisciplinary management
This is a report on one person who had a rare mix of problems after a kidney transplant. It describes the difficulty of treating this specific case. There are no new results or...
Diagnostic and Management Challenges in Mixed-Source MDR Sepsis in a Kidney Transplant Recipient with an Infected Sacral Pressure Ulcer Treated with VAC Therapy: A Case Report
This is a report on one person who had a kidney transplant and a serious infection. It describes the challenges of treating this specific case. There are no new results or general...
The Hospital Burden of Chronic Kidney Disease in Ireland: A National Analysis of Healthcare Utilisation, Mortality and Costs
This study looked at hospital records in Ireland to see how much kidney disease costs. It checked how often people were admitted and how long they stayed. The results show the...
Preferences for digital health services among patients with chronic kidney disease: a discrete choice experiment
This study asked people in China what they want in digital health tools for kidney disease. It used a survey method to rank different features. The results show what patients...
Supplemental Material for: Calcium Overload in Trisomy 21:An Underrecognized Cause of Persistent Hypercalcaemia -A Case Report
This is a case report about one child with Down syndrome. The child had high calcium levels that affected their kidneys. It is a single story, not a large study, so it does not...
Renal trauma in a pediatric Level 1 trauma center: morbidity, mortality, and the role of renal scintigraphy
This study looked at children with kidney injuries from trauma. It tracked their health outcomes and the use of a special kidney scan. It is an observational study, so it shows a...
Changes in hepatic functional reserve and renal function during hospitalization in patients with chronic liver disease
This study looked at 200 people with chronic liver disease who were in the hospital. It tracked how their liver and kidney blood tests changed during their stay. It is an...
Factors associated with reduced kidney function in hospitalized children with dehydration
This study followed 179 children in the hospital who were dehydrated. It looked for factors that might lower their kidney function. It found that some children had lower kidney...
ASSOCIATION OF METABOLIC SYNDROME WITH CONVENTIONAL RENAL FUNCTION PARAMETERS AMONG ADULTS ATTENDING A TERTIARY CARE HOSPITAL: AN ANALYTICAL CROSS-SECTIONAL COMPARATIVE STUDY
This study looked at adults in a hospital who had metabolic syndrome. Metabolic syndrome is a group of conditions like high blood pressure and high blood sugar. The study found...
Estimated small dense low-density lipoprotein cholesterol and incident myocardial infarction in patients undergoing dialysis: a nationwide cohort study
This large study followed 21,671 people on dialysis. It looked at a specific type of cholesterol in the blood. It found a link between higher levels of this cholesterol and heart...
Prevalence and Predictors of Chronic Kidney Disease of Undetermined Cause (CKDu) among Small-Scale Fishers in Northwest Tanzania: Application of DEGREE Protocol
This is a preprint, which means it has not been fully checked by other experts yet. It is a study about kidney disease in fishers in Tanzania. Because there is no abstract, we do...
Diagnostic value of hematological inflammatory indices for renal involvement in adult IgA vasculitis
This study looked at 67 adults with a rare blood vessel disease. It found that certain blood markers were higher in people who also had kidney problems. This shows a link between...
Lung ultrasound-guided protocolized fluid management versus conventional central venous pressure-based management in monitoring extravascular lung water during the perioperative period of percutaneous nephrolithotomy: a randomized controlled trial
This trial followed 181 people having kidney stone surgery. It compared two ways to manage fluids during the operation. One group used lung ultrasound, while the other used a...
Code for: Can Routine Clinical Variables Substitute for Urine Albumin Testing in Moderate Chronic Kidney Disease? A Machine-Learning Analysis of NHANES 2015–2018
This item is a set of computer code for a study. The study looked at 687 people with moderate kidney disease. It tried to see if standard blood tests could replace urine tests for...
A Visual Protocol for Selecting, Initiating, and Monitoring Hemodialysis or Peritoneal Dialysis in Adults with Uremic-Stage Chronic Kidney Disease
This is a visual guide on how to start and monitor dialysis. It is a protocol, not a study with results. It helps doctors and nurses follow standard steps for care.
Cultural Beliefs and Treatment Adherence with Chronic Kidney Disease Patients: A Leininger-Based Study
This study looked at how cultural beliefs affect how well people follow their kidney treatment plans. It surveyed 74 patients. It shows a link between beliefs and adherence, but it...