← brief for 2026-10-10 · Slowing decline

Gut microbiota‐derived tryptophan metabolite attenuates calcium oxalate nephropathy by suppressing renal tubular cell apoptosis through the AhR – SOCS3 – STAT1 axis

Article D Peer reviewed Preclinical

Key takeaways

This study used mice to test a compound called indole-3-propionic acid (IPA). It comes from gut bacteria and is made from tryptophan. Giving mice IPA by mouth reduced kidney crystal buildup and cell damage. The work was done in animals, not people yet. It suggests a new path for treating calcium oxalate kidney stones.

Who did this work

Ya Li (Sichuan University) · Jiawei Chen (Sichuan University) · 乐德林 (Sichuan University) · Zhongyu Jian (Sichuan University) · Linhu Liu (Sichuan University) · Menghua Wang (Sichuan University) · Jingwen Wei (Sichuan University) · Xiaoting Chen (Sichuan University) · Mengzhu Yang (Sichuan University) · Tianyue Li (Sichuan University) · Liyuan Xiang (Sichuan University) · Liao Banghua (Sichuan University)

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-10-09
https://doi.org/10.1002/path.70135