Kidney research, 2026-10-05
A new drug slowed kidney decline in people without diabetes.
The strongest news today is a major trial showing a new drug can slow kidney decline in people without diabetes. Other reports covered smaller studies on magnesium and quality of life. These smaller studies offer useful links but do not prove new treatments yet.
Decoding autophagy-immune crosstalk in diabetic kidney disease: CCL2 as a central hub linking autophagic flux to macrophage polarization
This preprint used computer models to study how cell cleanup processes link to immune changes in diabetic kidney disease. It identified specific genes that may play a role. This is...
GATM-mediated creatine synthesis alleviates acute kidney injury by promoting lipophagy in renal tubular epithelial cells.
This study looked at how a specific enzyme helps protect kidney cells from sudden injury. The work was done in mice and cells, not in people yet. It suggests this enzyme may help...
Heart failure in chronic kidney disease: what the second universal definition changes.
This review explains how new rules for heart failure change care for people with kidney disease. It looks at how doctors can spot early signs of heart trouble. There are no new...
Recommendations of the Brazilian Society of Nephrology for the management of chronic kidney disease in primary health care.
This guideline gives advice on how to manage kidney disease in primary care. It is a set of recommendations, not a new study. There are no new results from this item.
Finerenone in Reducing Proteinuria: Clinical Effects, Underlying Mechanisms, and Associated Cardiorenal Protection.
This review summarizes how finerenone, a blood pressure drug, helps lower protein in the urine. It explains the drug's effects on the heart and kidneys. There are no new results...
Nephrotic range proteinuria and rapid progression to end-stage kidney disease in seronegative pauci-immune necrotizing glomerulonephritis masked by cutaneous lesions: a case-based review.
This review describes a single case of a young woman with a rare kidney disease. It highlights how skin issues can hide the signs of kidney damage. There are no new results from...
Impact of GST and TP53 gene polymorphisms on susceptibility to end stage renal disease: A case-control analysis.
This study compared 305 people with end-stage kidney disease to 305 healthy people. It looked for gene differences that might raise the risk of kidney failure. This is an...
Network pharmacology, single-cell transcriptomics, machine learning and experimental validation identifying CHEK2 and HPGD as key therapeutic targets of berberine in diabetic nephropathy.
This study used computer models and lab tests to find how a drug called berberine works. It looked at cells and genes, not people. It suggests the drug may help kidney disease, but...
Vascular calcification: pathogenic mechanisms, signaling crosstalk and translational therapeutics.
This is a review of how calcium builds up in blood vessels. It explains the science behind this process. It does not report new test results. It helps doctors understand the...
A standardized fraction of Cajanus scarabaeoides attenuates diabetic nephropathy via antiglycation, anti-inflammatory, and anti-fibrotic mechanisms.
This study tested a plant extract in cells and animals. It found that the extract may protect kidneys from diabetes damage. This is preclinical research, so it has not been tested...
Postoperative sensorineural hearing loss associated with prolonged hypocalcemia.
This is a case report about one woman who lost her hearing after surgery. It was linked to low calcium levels. It is not a large study, so it does not provide general evidence for...
Predictive Molecular Biomarkers in Pediatric Steroid-Resistant Nephrotic Syndrome: A Systematic Review.
This review looked at 11 studies involving 718 children. It found that certain blood tests can help predict a tough form of kidney disease. This is a systematic review, which is a...
Multifactorial causes of severe persistent hypercalcemia in an immunosuppressed woman with chronic kidney disease.
This is a case report about one woman with high calcium levels. It describes her specific medical situation and treatment. It is not a large study, so it does not provide general...
Integrated Eye鈥揔idney Biomarkers in Diabetes: Retinal Microvascular Imaging and Renal Dysfunction as Complementary Indicators of Systemic Microangiopathy
This study looked at how eye scans and kidney tests work together in people with diabetes. It found that damage in the eyes often matches damage in the kidneys. This is an...
Early serum phosphate trajectories after acute kidney injury onset and their association with mortality in critically ill patients: derivation in MIMIC-IV and external evaluation in eICU-CRD
This is a preprint about phosphate levels in sick patients. It looks at how these levels change after kidney injury. It is not yet published in a peer-reviewed journal. There are...
Prevalence of Intradialytic Hypertension Among Patients Undergoing Maintenance Hemodialysis: A Single-Center Cross-Sectional Study Using Three Diagnostic Definitions
This is a preprint of a study on high blood pressure during dialysis. It is not yet published in a peer-reviewed journal. There are no final results to report yet.
Circulating miRNA-21-5p, miRNA-486-5p, and miRNA-122-5p as predictors of coronary artery calcification in patients with chronic kidney disease
This study looked at 150 people to see if certain blood markers predict hardening of the heart arteries. It found a link between these markers and the amount of calcium in the...
Intraoperative Blood Pressure Variability and Postoperative Acute Kidney Injury: A Pre-specified Analysis Plan (INSPIRE / MOVER)
This is a plan for a study that will look at blood pressure swings during surgery. It aims to see if these swings link to sudden kidney injury after surgery. There are no results...
Glucagon-Like Peptide-1 Agonists and Blood Pressure Regulation: Molecular Mechanisms and Cardiovascular Implications.
This review explains how diabetes drugs called GLP-1 agonists affect blood pressure. It summarizes the known science on how these drugs work in the body. There are no new results...
The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect
This large international trial is recruiting people with chronic kidney disease to test various treatments. It aims to find the best drugs to slow kidney decline. There are no...
Clinical outcomes of intravascular ultrasound-guided drug-coated balloon angioplasty for acute coronary syndrome: A single-center retrospective cohort study.
This study compared two ways to open blocked heart arteries. It looked at outcomes for people with acute coronary syndrome. This is an observational study, so it shows a link but...
Identification of Risk Factors and Prediction Models for Acute Kidney Injury in Hospitalized Elderly Patients with Heart Failure.
This study looked at 7,076 older adults with heart failure in the hospital. It built a model to predict who might get sudden kidney injury. This is an observational study, so it...
Preventative nephrology in the cardiovascular鈥搆idney鈥搈etabolic era
This article argues that doctors should treat heart, kidney, and metabolic health as one system. It suggests a shift from reactive care to early prevention. There are no new...
Innovative holistic treatment for CKM: what lies ahead?
This review looks at how to treat heart, kidney, and metabolic diseases together. It discusses new ways to manage these connected conditions. There are no new results from this...
Implementation of guideline-directed cardioprotective therapy in patients living with type 2 diabetes in outpatient cardiology ambulatory setting: the Italian CardioMET registry.
This study tracked 2,527 people with type 2 diabetes in Italy. It looked at how often doctors prescribed heart-protecting drugs. This is an observational study, so it shows a link,...
Trajectories of Albuminuria and Non-Albumin Proteinuria After Sequential Addition of Finerenone for Residual Albuminuria Despite Established SGLT2 Inhibitor Therapy in Diabetic Kidney Disease: A Real-World Cohort Study.
This study followed 86 people with diabetic kidney disease. It looked at protein in the urine after adding a new drug. This is an observational study, so it shows a link, not proof...
In CKD without diabetes, finerenone vs. placebo slowed kidney function decline over 32 mo.
A large trial found that finerenone slowed the loss of kidney function in people with chronic kidney disease who do not have diabetes. The study ran for 32 months. This drug helps...
A Major Role of VEGFR1 Blockade in Protecting Glomerular Endothelium in Experimental Diabetes.
This study used mice to test a drug that blocks a specific protein. The goal was to see if it could protect the tiny blood vessels in the kidneys. The results suggest it may help...
Effects of Lanthanum Carbonate on Whole-Body Phosphorus and Calcium Balance in Adults With Chronic Kidney Disease and Normophosphatemia.
This small trial tested a kidney binder called lanthanum carbonate in 15 adults with normal blood phosphorus levels. The study ran for 12 weeks and found that the drug did not...
Long-term integrative personalized medicine care in massive brainstem hemorrhage: A CARE-compliant case report.
This is a single case report of a person with a brain bleed. It describes how they were treated with a mix of standard and traditional medicine. It is one person's experience, not...
Latent profile analysis of health-related quality of life among patients with chronic kidney disease in Bangladesh: a cross-sectional study.
Researchers surveyed 315 patients in Bangladesh to look at their quality of life. They found different groups of patients with varying levels of well-being. This study shows a link...
Cardiac Adaptation in a Murine Iliac Arteriovenous Fistula Model and the Impact of Sex and N-Acetylcysteine Supplementation.
This study used mice to see how dialysis connections affect the heart. It tested if a common antioxidant called NAC could help protect heart muscle. The results are from animals,...
A Composite Ovine Forestomach Matrix and Hyaluronic Acid CAMP for the Treatment of Full Thickness Wounds of the Foot in People With Diabetes: A Randomized Controlled Trial.
A large trial tested a new skin patch made from sheep tissue. It helped heal deep foot wounds in people with diabetes. The study included 143 people. This is a strong test that...
Early Outpatient bFGF-Based Wound Care for Foot Lesions in Haemodialysis Patients: A Real-World Stepwise Limb-Salvage Strategy From Japan.
This study looked at 20 people on dialysis who had foot sores. They used a cream with a growth factor to help the wounds heal. The study shows a link between this treatment and...
Association between immunologic risk factors and cardiovascular complications following pediatric kidney transplantation.
This study looked at 72 children who got kidney transplants. It found a link between certain immune risks and heart problems after the surgery. This shows a connection, but it is...
Successful Kidney Transplantation from a Living Donor with Double Inferior Vena Cava and Three Renal Veins: Case Report and Literature Review
This is a preprint about a rare kidney transplant case. The donor had unusual blood vessels. It is not yet published in a peer-reviewed journal. There are no final results to...
DESENVOLVIMENTO DE UM MODELO AJUSTADO AO ESCORE FRAX NA PREDI脟脙O DE FRATURAS EM RECEPTORES DE TRANSPLANTE RENAL
This study looks at a tool used to predict bone breaks in kidney transplant patients. It is a review of existing data to check if the tool works well. There are no new trial...
Assessment of Kidney Endocrine Function to Evaluate Transplant Kidney Quality and the Role of the (Pro)renin Receptor in Kidney Development
This thesis looks at whether donor kidneys can be tested for quality before they are transplanted. It examines how the kidneys produce certain hormones while being kept alive...
Racial and Ethnic Disparities in Access to Home-Based Renal Replacement Therapies Among Incident End-Stage Renal Disease Patients in the United States.
This study looked at US data from 2014 to 2020. It found that some racial and ethnic groups have less access to home dialysis. This is an observational study, so it shows a link,...
The lived experience of adults with kidney failure across treatment modalities: umbrella review of qualitative evidence syntheses
This review looks at how people feel when they have kidney failure. It combines many studies on the daily life of patients. It focuses on personal experiences, not medical test...
Global trends in urological cancers: an analysis of the global burden of disease study 2023
This report tracks kidney and other urinary cancers worldwide from 1990 to 2023. It looks at how many people get sick and how many die. It is a summary of global data, not a new...
The Overlooked Burden of Chronic Kidney Disease in African Intensive Care Units: A Call for Standardized Renal Surveillance
This article argues that hospitals in Africa need better tools to track kidney health. It uses data from 848 adults in a South African ICU to make its case. It is a call for...
Prevalence and antibiogram of uropathogens among Jordanian patients with chronic kidney disease
This study looked at urine samples from 150 people in Jordan. It found that people with chronic kidney disease often have bacteria in their urine that resist common antibiotics....
Prolonged infusion of meropenem for suspected intracystic infection in polycystic kidney disease during pregnancy: a case report
A pregnant woman with polycystic kidney disease had a hard-to-treat kidney infection. Doctors used a strong antibiotic for a long time to treat it. This case shows how doctors...
Case Report: When muscle edema is not a myositis flare: Legionella pneumonia complicated by rhabdomyolysis and acute kidney injury in long-standing polymyositis
A 70-year-old woman with a long history of muscle disease got a severe lung infection. The infection caused her muscles to break down, which hurt her kidneys. This case shows that...
Hybrid 99mTc-DTPA Dynamic Scintigraphy and SPECT/CT Overturn Presumed Renal Agenesis by Characterizing a Functioning Pelvic Ectopic Kidney in Pediatric VACTERL Association: An Observational Analytic Study
This report describes a 4-year-old girl with a rare group of birth defects. Doctors thought she was missing a kidney, but a special scan showed it was just in the wrong place. The...
The Use of Risk Prediction to Identify Patients at Risk for Chronic Kidney Disease: Patient and Provider Interventions for Patients at High Risk for Chronic Kidney Disease
This trial is starting to test if better communication between doctors and patients leads to more kidney testing. It plans to reach up to 1,000 people at high risk for kidney...
https://www.theisn.org/blog/event/isn-webinar-implementation-science-for-more-effective-clinical-trials-preparatory-webinar-for-the-wcn27-clinical-trials-course/
This is a page for a webinar on how to run better clinical trials. It is an educational event, not a research study. There are no results to report.
https://www.theisn.org/blog/event/isn-webinar-tropical-infections-and-the-kidney-presentation-pitfalls-and-prevention/
This is a page for a webinar on tropical infections and the kidney. It is an educational event, not a research study. There are no results to report.
https://www.theisn.org/blog/event/isn-webinar-turning-kidney-health-commitments-into-country-action/
The International Society of Nephrology is hosting a webinar. It will discuss how countries can turn kidney health promises into real actions. This is a planned event, not a study....
Evolution of Stakeholder Involvement and Scope of Research Priority-Setting Studies in Kidney Disease: A Systematic Review
This review looks at how kidney research priorities are set. It checks if patients and caregivers are included in the process. There are no new clinical results from this item.