← brief for 2026-10-05 · Slowing decline

Network pharmacology, single-cell transcriptomics, machine learning and experimental validation identifying CHEK2 and HPGD as key therapeutic targets of berberine in diabetic nephropathy.

Key takeaways

This study used computer models and lab tests to find how a drug called berberine works. It looked at cells and genes, not people. It suggests the drug may help kidney disease, but it has not been tested in humans yet.

Who did this work

Pu Y (Department of Nephrology of Jiangbei Campus, the First Affiliated Hospital of Army Medical University, Chongqing, 400020, China.) · Chang H (Department of Nephrology, the First Affiliated Hospital of Army Medical University, Chongqing, 400038, China.) · Chen W (Department of Nephrology of Jiangbei Campus, the First Affiliated Hospital of Army Medical University, Chongqing, 400020, China.) · Zhang H (Department of Nephrology, the First Affiliated Hospital of Army Medical University, Chongqing, 400038, China.) · Chen W (Department of Nephrology of Jiangbei Campus, the First Affiliated Hospital of Army Medical University, Chongqing, 400020, China.) · Zhao H (Department of Nephrology, the First Affiliated Hospital of Army Medical University, Chongqing, 400038, China. [email protected].) · Sun D (Department of Nephrology of Jiangbei Campus, the First Affiliated Hospital of Army Medical University, Chongqing, 400020, China. [email protected].)

Source

Article · Europe PMC, CKD · 2026-10-01
https://doi.org/10.1007/s10142-026-02052-2