Kidney research, 2026-10-15
New real-world data shows a targeted drug helps people with IgA nephropathy.
Today's news focuses on how new tools and treatments work in daily life. The most important update is that a specific drug for IgA nephropathy is showing real-world benefits. Other reports highlight better ways to detect diabetes risk and early tests for blood pressure control. These findings help doctors and patients make more informed choices about care.
Integrated transcriptomics identifies key genes and pathways driving CKD to ESRD progression: implications for diagnosis and prognosis
This study looked at genes in cells to find what drives kidney disease. It used computer models to find key genes. This was in cells, not people yet. It may help find new tests in...
Sodium-Glucose Cotransporter 2 Inhibitors: A Scoping Review of Current Evidence, Mechanisms, and Adverse Effects.
This is a review of a class of drugs called SGLT2 inhibitors. It looks at how they work and their side effects. There is no abstract, so we have not read the study. There are no...
Optimised Cardiovascular and Renal Protection in Patients With Chronic Kidney Disease and Cardiovascular Disease
A new trial is starting to test if a specialized clinic can help people with both heart and kidney disease. The clinic will provide structured care based on current guidelines. The...
Acute kidney disease after acute kidney injury: incidence, risk factors, and association with de novo chronic kidney disease.
This study followed 23,868 people who had a sudden drop in kidney function. It found that about 46% of them had kidney issues that lasted for weeks. This shows a link between...
Association Between Nocturnal Blood Pressure Dipping and Renal Injury: A Systematic Literature Review
This review looked at studies from 2015 to 2026. It found a link between blood pressure that does not drop at night and kidney injury. This shows a connection, not proof of cause....
Pathophysiological Insights of KIM-1 in Sepsis-Associated Acute Kidney Injury: Insights into the molecular mechanism: A Narrative Review
This review explains how a protein called KIM-1 works in kidney cells. It looks at how the body controls this protein during severe infection. This was in cells and molecules, not...
Acute kidney disease following cisplatin treatment in head and neck cancer: risk factors and survival impact
This study looked at cancer patients who took a drug called cisplatin. It found that kidney damage after treatment is linked to lower survival rates. This shows a link, not proof...
Epidemiology of Uncontrolled and Treatment‑Resistant Hypertension: A Registry‑Based Observational Study
This study looked at blood pressure records in Sweden. It checked how many people had high blood pressure that did not go down with medicine. It shows a link, but it is not proof...
Glomerular Filtration Rates and Risk of Adverse Health Outcomes
This article examines how kidney filtering rates affect overall health risks. The record does not include the full text or results. There are no findings to report yet.
Supplemental Material For : Tubuloreticular Inclusions in Kidney Tissues of Patients with Lupus Nephritis: An Ultrastructural Biomarker of Type I Interferon‑Driven Disease Activity
This study looked at kidney tissue from 327 people with lupus nephritis. It checked for specific cell changes that signal disease activity. This shows a link between these changes...
Histone Demethylase KDM6A Mediates the Dysregulation of Lipid Metabolism Genes and Cellular Dysfunction in a High Glucose Model of Diabetic Kidney Disease
This study looks at how a specific protein affects kidney cells in a high sugar environment. The record does not include the full text or results. There are no findings to report...
Gramine Suppresses Myofibroblast Activation and ECM Accumulation in Renal Fibrosis by Targeting the NF‐κB/NLRP3 and TGF‐β1/Smad Pathways
A plant compound called gramine stopped kidney cells from turning into scar tissue in a lab dish. The study used rat kidney cells to test this effect. It was done in cells, not in...
CD38-targeted therapies in kidney disease: evidence maturity, disease-stage dependence, and biomarker-guided retreatment
This review looks at drugs that target a protein called CD38. It covers how these drugs work in kidney disease and transplants. It summarizes what is already known from past...
Circ_0024390 promotes renal tubular EMT through the miR-6890-3p/CHD4 axis: implications for renal interstitial fibrosis
A small RNA molecule called circ_0024390 made kidney cells turn into scar tissue in a lab dish. The study used human kidney cells to test this. It was done in cells, not in people...
Cardiometabolic Efficacy and Renal Safety of Saroglitazar in Indian Patients with Type 2 Diabetes — a 36-Month Retrospective Observational Study
This study looked at 110 people with type 2 diabetes who took a drug called saroglitazar for three years. It checked how the drug affected their blood sugar, cholesterol, and...
Analytical Characterization, Pharmacokinetics, Safety, and Preliminary Immunogenicity of GNR-062, an Agalsidase Beta Biosimilar Candidate, in Healthy Male Volunteers
This small trial tested a new drug for Fabry disease, a rare condition that can damage the kidneys. The study involved healthy male volunteers to check safety and how the body...
Development and multi-database validation of machine learning models for 28-day mortality prediction in ICU patients with COPD and pulmonary hypertension
This study used computer models to predict which patients in the ICU would die within 28 days. It focused on people with lung disease and high blood pressure in the lungs. The...
Effect of a Single Hemodialysis Session on Hemostatic Function in Patients With Chronic Kidney Disease
This study looked at 32 people on dialysis to see how one session affects their blood clotting. It measured blood samples before and after the treatment. The results show that...
Sphingolipid–renal interplay in coronary artery calcification: ceramide profiling and imaging validation from the CRUISE-MET study
This study looked at 851 people with heart disease to see if certain fats in the blood are linked to calcium buildup in the arteries. It focused on people with kidney disease. The...
Association of Oliguria With Acute Kidney Injury, Chronic Kidney Disease, and Mortality: Determining the Optimal Threshold in Critically Ill Patients
This large study looked at 4,999 people in the ICU to find the best warning sign for kidney damage. It found that low urine output is a strong predictor of kidney injury and death....
Epigenetically silencing gluconeogenic enzyme PCK1 by EZH2 promotes renal tubulointerstitial fibrosis
This study looked at how a protein called EZH2 affects kidney cells in the lab. It found that this protein can cause scarring in the kidney tissue. This was done in cells, not...
Leveraging Urinary Proteomics to Advance Pathophysiologic and Biomarker Perspectives of Chronic Kidney Disease in Cats
Researchers looked at urine samples from cats to find signs of kidney disease. They identified 2,219 proteins and found one, called MMP-7, that may help diagnose the condition....
Mean-Centering Alters Pathway-Based Transcriptomic Comparisons of Feline and Mouse Kidney Disease
This study checked how a math step changes the comparison of kidney disease in cats and mice. The team found that removing the average value first made the two species look much...
GLP-1 receptor agonists as novel renoprotective agents in lupus nephritis
A diabetes drug called liraglutide may protect kidneys in mice with lupus. The study used mice that are prone to developing lupus and kidney damage. It showed the drug helped...
IMPACT OF DIABETES MELLITUS ON MORTALITY AMONG ADMITTED INTERNAL MEDICINE PATIENTS
This study looked at hospital records to see if diabetes affects the chance of dying in the hospital. It is an observational study, which means it shows a link but not proof of...
Immunoglobulin A Nephropathy Associated with Systemic Disease: Clinical Spectrum and Long-Term Kidney Outcomes in a Single-Center Cohort
This study followed 46 adults with a specific type of kidney disease called IgA nephropathy. These patients also had other long-term health conditions. The researchers looked at...
Declining Kidney Function Is Associated with Altered Erythrocyte Membrane Fatty Acid Profiles and Estimated Enzymatic Indices
This study looked at blood samples from 282 people with different levels of kidney function. It found that as kidney function declined, the fatty acids in red blood cells changed....
Chronic Kidney Disease Progression Prediction Using Clinical Data
This paper describes a computer program that uses patient data to predict kidney health. It tested the program on 21,000 records. This is a data analysis, not a test in people, so...
Association of miR-671-3p expression with clinical efficacy and complications in hemodialysis patients.
This study looked at 163 people on dialysis in China. It checked a specific molecule, miR-671-3p, in their blood. It found a link between this molecule and vascular calcification....
Beyond Hemodynamics: Uremic Toxins, Post-Translational Modifications, and Inflammatory-Metabolic Remodeling in Uremic Cardiomyopathy.
This review explains how kidney failure changes the heart. It looks at toxins and inflammation, not just blood pressure. It summarizes existing knowledge but does not report new...
RealxWorld Effectiveness of Targeted-Release Budesonide in IgA Nephropathy with Near-Universal SGLT2 Inhibitor Use.
This study tracked real patients with IgA nephropathy who took a targeted budesonide drug. It shows how the drug works in daily life, not just in a controlled trial. This type of...
Utilities of Sodium-Glucose Cotransporter-2 Inhibitor in the Intensive Care Units.
This review discusses using SGLT2 inhibitors in the ICU. It looks at safety and benefits for critically ill patients. It summarizes current evidence but does not report new trial...
GLP-1 Receptor Agonists and Lipoprotein (a): Insights, Gaps and Clinical Implications in Cardiovascular Diseases.
This review looks at how GLP-1 drugs affect a heart risk marker called Lp(a). It discusses the link between these drugs and heart health. It does not report new trial results.
Integrative multi-omics analysis reveals the PFAS-gut microbiome-FN1 axis in chronic kidney disease: From exposome to therapeutic target.
This study used computer models and lab data to link environmental chemicals to kidney scarring. It looked at how gut bacteria and a protein called FN1 might be involved. This was...
Calcium Overload in Trisomy 21: An Underrecognized Cause of Persistent Hypercalcaemia - A Case Report.
This report describes one child with Down syndrome who had high calcium levels. It shows how this can hurt the kidneys. It is a single case, not a study with results for many...
Retatrutide treatment in streptozotocin-induced diabetic rats: renal inflammatory cytokines, HIF‑1α expression, and histopathological injury profile.
This study tested a new drug called Retatrutide in rats with diabetes. It looked at how the drug affected kidney inflammation and damage. This was done in animals, not people yet.
Novel composite renal indicators outperform traditional markers in identifying type 2 diabetes risk in middle-aged and older Chinese adults.
This study looked at 8,841 middle-aged and older adults in China. It found that new combined kidney tests are better at spotting type 2 diabetes than standard tests. This shows a...
Multi-omics analysis explores the potential mechanisms of Huangtcia renifolia ethanolic extract against osteoporosis in ovariectomized rats.
Researchers tested a plant extract in rats to see if it protects bones. The study used advanced tools to look at how the plant works inside the body. This was done in animals, not...
Targeting calciphylaxis: the emergence of vitamin K as a potential treatment.
This review looks at a rare and painful skin condition called calciphylaxis. It mostly hits people with advanced kidney disease who are on dialysis. The article explains how...
Perceived severity and benefits show a preliminary conditional association with kidney-protective behaviors in type 2 diabetes with early kidney function decline: an exploratory health belief model analysis.
This study looked at how people with diabetes and early kidney decline think about their health. It found that believing a condition is serious and that actions help can lead to...
Redefining Kidney Stone Incidence: Emerging Age-Related Patterns
A large study of 494,745 people in the UK Biobank followed them from 2010 to 2022. It found that the risk of getting kidney stones rises with age. This link was stronger in men...
Inflammatory and antioxidant dietary indices across cardiovascular-kidney-metabolic stages: a scoping review protocol
This is a plan for a future review of diet and kidney health. It will look at how food affects inflammation. There are no results yet from this study.
Weight Management Services for Patients with Advanced Chronic Kidney Disease in Canada: A Survey of Nephrologists
This is a survey of kidney doctors in Canada. It asks about weight management services for patients with advanced kidney disease. There are no results yet, as it is a survey that...
Establishment of a Diet-Induced Systemic Metabolic SyndromeModel Reveals Early Renal Alterations and the Nephroprotective Potential of Three Jabuticaba (Myrciaria cauliflora) Formulations.
This study tested a berry called jabuticaba in animals with metabolic syndrome. It looked at whether the berry could protect the kidneys from early damage. This was done in...
Association of Life-Course Stressful Life Events with Incident Chronic Kidney Disease: The Potential Mediating Role of Frailty
This study looked at how stressful life events in childhood and adulthood are linked to kidney disease in older adults. It found that stress may lead to frailty, which then...
An Evidence-Based Approach to Nonpharmacological Blood Pressure Management Among African Americans.
This pilot study involved 21 African Americans with high blood pressure. They received six weeks of faith-based health education. The study measured changes in their self-care and...
Autophagy-lysosome flux failure in diabetic kidney disease: tubular vulnerability and cell-state remodeling.
This review looks at how kidney cells fail to clean up damaged parts in diabetes. It focuses on the cell level, not people yet. The goal is to understand why kidney cells get sick....
Non-invasive assessment of estimated glomerular filtration rate using lens autofluorescence in a population without chronic kidney disease.
This study tested a new eye scan to check kidney health. It looked at people without kidney disease. It shows a link between the eye scan and kidney function. This is not a proven...
Diagnostic Accuracy and Renal Safety of Carbon Dioxide Angiography in Lower Limb Angiography: A Systematic Review and Meta-Analysis
This review combined data from many studies to check if carbon dioxide is safer for kidneys than standard dye. It looks at how well the images work and how they affect kidney...
MSC-Derived Small Extracellular Vesicles Alleviate Renal Fibrosis in Hyperuricemic Nephropathy via Suppression of Epithelial Mesenchymal Transition.
This study tested a new treatment in rats, not people. It used small vesicles from stem cells to treat kidney scarring. The rats had a condition caused by high uric acid. The...
Attitudes Toward Xenotransplantation Among Kidney Transplant Recipients, Candidates, and Living Donors: A Cross-Sectional Survey in Japan.
This survey asked 100 people in Japan about their views on getting a pig kidney. Most said they would accept a pig kidney if it was available. This shows a link between patient...
Cardiac xenotransplantation: from concept to clinical reality.
This review looks at how pig heart transplants have moved from a lab idea to real clinical use. It discusses the technology and the challenges involved. It is a summary of the...
Why do kidney transplants fail so early in young people?
This thesis looks at why kidney transplants fail early in young people. It uses a mix of social, medical, and genetic data. There are no new results yet from this specific...
Doença Renal Crônica e Transplante Renal: Da Progressão da Doença à Manutenção do Enxerto
This article reviews how kidney disease gets worse over time. It covers the steps needed before a person gets a kidney transplant. The text explains how to keep the new kidney...
Applying Quality Improvement Science to Clinical Trial Recruitment: Experience From the Obesity Management for Kidney Transplantation-2 (OKT-2) Vanguard
This article is about how to find people for a kidney transplant study. It is a published paper, but we do not have the full text to see the results. There are no new findings to...
Thymopoiesis-regulating genetic variant rs2204985 affects outcome of liver but not kidney transplantation
This study looks at a specific gene change and how it affects organ transplants. The record does not include the full text or results. There are no findings to report yet.
Molecular HLA matching in kidney transplantation: the emerging role of eplet mismatch analysis
This review discusses new ways to match donors and recipients for kidney transplants. It looks at how computer tools can find better matches. It summarizes existing research rather...
Clinical Outcomes, Risk Communication, and Follow-Up After Living Kidney Donation: A Retrospective Observational Cohort Study
This study looked at 91 people who donated a kidney to a living person. It checked how their health changed after the donation. The researchers also looked at how well the donors...
Program “Ayo Cek Ginjal!”: Pemeriksaan Ureum dan Kreatinin untuk Masyarakat Beresiko Tinggi di Desa Sokaraja Kidul
This report describes a community program in Indonesia that tested people's blood for kidney function. It aimed to educate the public and find those at risk. It is a description of...
Analysis code for sex disparity and the sex adjustment in creatinine-based chronic kidney disease staging, with conditional mutual information estimator diagnostics
This is a set of computer code for a study on kidney disease staging. It helps researchers check their math. There are no new patient results in this file.
COMPREENSÃO DE PESSOAS COM DIABETES MELLITUS SOBRE A RELAÇÃO ENTRE DIABETES E A DOENÇA RENAL CRÔNICA EM UM MUNICÍPIO NO AGRESTE DE PERNAMBUCO
This study looked at what 14 people with type 2 diabetes knew about kidney disease. It used interviews to check their understanding. The group was mostly women. This shows a link...
Sex-based Disparities in Cardio-Kidney-Metabolic Care Among Adults With Diabetes and Chronic Kidney Disease
This article is about differences in care for men and women with kidney disease. It is a published paper, but we do not have the full text to see the results. There are no new...
Beyond hematologic remission: what the kidney tells us in amyloid light-chain amyloidosis
This paper discusses how the kidneys react to a rare blood disease. It is a published article, but we do not have the full text to see the results. There are no new findings to...
The Influence of Deep Hypothermic Circulatory Arrest on the Incidence of Postoperative Acute Kidney Injury After Pulmonary Endarterectomy
This study looked at how a specific heart surgery affects the kidneys. It checked if stopping the blood flow for a long time caused sudden kidney injury. It shows a link, but it is...
Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury
This large trial compared two types of dialysis for people with sudden kidney failure. It found that the slower, continuous type was better than the standard fast type. The study...
Fatal tumor lysis syndrome presenting with extreme hyperuricemia and dialysis-requiring acute kidney injury in blast-phase chronic myeloid leukemia
This is a report about one person with a blood cancer. It describes how their kidneys failed suddenly. It is a single case, not a study with results for many people.
Rapid Ammonia Clearance Using Intensified Continuous Kidney Replacement Therapy in a Neonate With Type 1 Citrullinemia: A Case Report
This is a report on one newborn baby with a rare metabolic condition. It describes how a specific kidney treatment helped clear toxins. The record does not include the full text or...
Case Report: transient migratory pulmonary nodules with bronchial artery malformations in an autosomal dominant polycystic kidney disease patient: a case of recurrent hemoptysis
This report describes one 81-year-old man with polycystic kidney disease. He had unusual lung issues that were linked to his kidney condition. It is a single patient story, not a...
An interpretable machine learning framework for retrospective attribution of hospitalization costs in patients with chronic kidney disease
This study is about using computer models to track hospital costs for people with kidney disease. There is no abstract available, so the specific results are not known. It is a...
Kidney Function Trajectory and Cardiorenal Therapy Utilization in an Integrated Diabetes Kidney Disease Clinic Within a Regional Chronic Kidney Disease Program
This study looks at how kidney function changes over time in a clinic that treats both diabetes and kidney disease. There is no abstract available, so the specific results are not...
Prevalence and factors associated with physical function among patients undergoing maintenance hemodialysis in Buraydah, Saudi Arabia: a cross-sectional study
This study checked how well people on dialysis could do physical tasks. It found that many of them had trouble with basic movements. This shows a link between dialysis and physical...