← brief for 2026-10-15 · Slowing decline

Epigenetically silencing gluconeogenic enzyme PCK1 by EZH2 promotes renal tubulointerstitial fibrosis

Article D Peer reviewed Preclinical

Key takeaways

This study looked at how a protein called EZH2 affects kidney cells in the lab. It found that this protein can cause scarring in the kidney tissue. This was done in cells, not people yet. It helps scientists understand how kidney disease starts. More testing in people is needed to see if this can be treated.

Who did this work

Ming Wu · Peiqun Lin · Zhiqiang Yan · Yanzhe Wang · Anna Rinaldi · Pietro E. Cippà · Di Huang · Jiayi Qiao · 杨爱东 · Bo Tan · Chaoyang Ye · Dongping Chen

Source

Article · OpenAlex, CKD works · 2026-10-14
https://doi.org/10.1186/s43556-026-00617-y