← brief for 2026-10-15 · Slowing decline

Gramine Suppresses Myofibroblast Activation and ECM Accumulation in Renal Fibrosis by Targeting the NF‐κB/NLRP3 and TGF‐β1/Smad Pathways

Article D Peer reviewed Preclinical

Key takeaways

A plant compound called gramine stopped kidney cells from turning into scar tissue in a lab dish. The study used rat kidney cells to test this effect. It was done in cells, not in people yet. This suggests the compound might help stop kidney scarring in the future.

Who did this work

Shobhit Gairola (National Institute of Pharmaceutical Education and Research) · Archana Bhatta (National Institute of Pharmaceutical Education and Research) · Tushar Mishra (National Institute of Pharmaceutical Education and Research) · Ravinder Kumar Kaundal (National Institute of Pharmaceutical Education and Research)

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-10-14
https://doi.org/10.1002/ptr.70470