Kidney research, 2026-10-11
New data shows Nefecon beats steroids for a common kidney disease.
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A new real-world study found that Nefecon works better than steroids for a common kidney disease.
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A large review found that hidden high blood pressure is very common in people with kidney disease who are not on dialysis.
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A review found that an oral drug for kidney anemia works well for people on peritoneal dialysis.
Today's news focuses on practical treatments and monitoring for kidney disease. The strongest finding is that Nefecon outperforms steroids for a specific condition. Other reports highlight the importance of checking for hidden high blood pressure and managing anemia during dialysis.
Collapsing Focal Segmental Glomerulosclerosis Progression to ESRD Following Combination Therapy with Pembrolizumab and Enfortumab Vedotin: A Case Report
This is a report on one person who had kidney failure after cancer drugs. It is a preprint, so it has not passed peer review yet. It describes a rare side effect. It is not a large...
Early Initiation of Sodium-Glucose Cotransporter 2 Inhibitors in Acute Decompensated Heart Failure: Efficacy, Safety, and Implementation in Stabilized Patients.
This review discusses starting a new heart drug early in the hospital. It looks at safety and how well it works. There are no new results from this piece. It is a summary of what...
Comparison of cardiometabolic benefits and tolerability in patients on sustained low doses of semaglutide or tirzepatide.
This study looked at people taking very low doses of two weight-loss drugs. It used records from 29 million patients. It shows a link between low doses and certain health effects....
Current review of glucagon-like peptide 1 receptor agonists and risk of nonarteritic anterior ischemic optic neuropathy.
This review looks at a possible link between weight-loss drugs and vision loss. It is a summary of what is already known. There are no new results from this piece. It helps doctors...
Multisystem effects of sodium-glucose cotransporter-2 inhibitors beyond glycaemic control: an umbrella review of systematic reviews and meta-analyses.
This large review looked at the benefits and harms of a heart and kidney drug. It found the drug lowers the risk of heart failure and death. It also looked at other body systems....
Sotagliflozin Reprograms Hepatic Lipid Metabolism and Attenuates Atherosclerosis Beyond Empagliflozin in CKM Mice.
This study looked at a heart and kidney drug in mice. It found the drug changed how the liver handles fat. It also seemed to slow the buildup of plaque in the arteries. This was in...
Data-driven clinical phenotypes of diabetic kidney disease and their association with disease progression: a real-world cohort study
This study looks at how kidney disease from diabetes progresses in real-world patients. It uses data to group patients into different types. There are no results yet because the...
Modifiable risk factors, tenofovir use and incident chronic kidney disease among people with HIV and people without HIV
This study checks if certain risk factors and a drug called tenofovir lead to new kidney disease. It compares people with and without HIV. There are no results yet because the full...
U-shaped association of platelet-to-lymphocyte ratio with all-cause and cardiovascular mortality in hypertension: mediating role of renal dysfunction in a nationwide cohort (NHANES 2005–2018)
This study checks if a blood test ratio links to death in people with high blood pressure. It looks at how kidney function plays a role. There are no results yet because the full...
Association of Albuminuria with Preserved eGFR and Mortality in Pooled NHANES 2007–2018: Conventional and Machine Learning Survival Analyses
This study looked at data from US adults whose kidney filtering rate was still normal. It found that having protein in the urine is linked to a higher risk of death. This shows a...
Long-Term Major Adverse Kidney and Cardiovascular Events in Predialysis Chronic Kidney Disease: A Real-World Cohort Study
This study followed 263 adults with kidney disease for at least five years. It looked at who developed serious kidney or heart problems. This is an observational study, so it shows...
FTO-mediated m6A modification of EGR1 mRNA promotes podocyte injury and inflammation via STING1 in diabetic kidney disease
This study looked at kidney cells in the lab and in people with diabetes. It found that a specific protein change can damage the tiny filters in the kidney. This was in cells and...
Interleukin-37 does not confer protection against stone formation or kidney injury at the peak of disease in a murine calcium oxalate model
This study used mice to test if a certain protein protects the kidney from stone damage. It found that the protein did not help at the peak of the disease. This was in animals, not...
Serum Irisin as a Potential Biomarker of Diabetic Nephropathy Severity in Type 2 Diabetes Mellitus
This study looked at 93 people with type 2 diabetes. It found that a blood marker called irisin was lower in people with more severe kidney damage. This shows a link, but it is not...
Calcium phosphate nephrolithiasis in a cystinuria carrier: a case report
This is a report on one person with kidney stones. It describes how a specific gene change might have played a role. It is a single case, not a study with results for many people.
Kidney Outcomes in Offspring Exposed to Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis
This review looked at many studies to see if high blood pressure during pregnancy affects the child's kidneys. It found a link between this condition and kidney problems in the...
Heart-to-kidney signal by extracellular vesicles promotes kidney injury in cardiorenal syndrome
This study used mice to see how a heart attack can hurt the kidneys. It found that small particles from the injured heart travel to the kidneys and cause damage. This was done in...
Oral Anticoagulants in Patients With Atrial Fibrillation and Advanced or End-Stage Renal Disease: A Systematic Review and Meta-Analysis.
This review compared blood thinners for people with irregular heartbeats and severe kidney disease. It looked at how well these drugs prevent strokes and how much they cause...
Biomarkers and Risk Prediction in Cardiovascular-Kidney-Metabolic Syndrome: A Comprehensive Review.
This review discusses blood tests that can predict how heart and kidney diseases will progress. It covers both old and new markers. It is a summary of existing knowledge, not a new...
The Solitary Functioning Kidney: From Pathophysiology to Long-Term Management.
This review explains what happens when a person has only one working kidney. It covers how this can lead to kidney disease over time. It is a summary of medical knowledge, not a...
Clinical and genetic risk factors for apolipoprotein L1-mediated chronic kidney disease in people of African ancestry with HIV.
This article explains how a specific gene, called APOL1, can cause kidney disease in people of African ancestry who have HIV. It notes that controlling the HIV virus can lower the...
Relationship Between Hemodialysis Duration and Degree of Sensorineural Hearing Loss Based on Pure Tone Audiometry
This study checked if the length of time on dialysis is linked to hearing loss. It looked at 30 patients in Indonesia. The results show a connection between dialysis duration and...
A randomized trial of high versus low serum bicarbonate targets and glomerular filtration rate decline in stage 3–4 chronic kidney disease
This trial tested if a higher target for blood bicarbonate levels slows kidney decline. It involved 58 people with stage 3 or 4 kidney disease over 104 weeks. The study found that...
SGLT2 beyond the kidney: an inducible player in endothelial dysfunction and cardiovascular diseases
This review discusses how SGLT2 drugs, which are often used for diabetes, affect the heart and blood vessels. It notes that these drugs help with heart failure and kidney disease....
Combined empagliflozin and liraglutide therapy protects against tacrolimus-induced pancreatic and renal injury associated with oxidative stress reduction.
In rats, two diabetes drugs together helped protect the kidneys from damage caused by a transplant drug. The study used male rats for 4 weeks. This was in animals, not people yet....
GLP-1-based therapies in lung diseases.
This review discusses how diabetes drugs might help with lung diseases. It notes these drugs have benefits for the heart and kidneys. It is a review of existing ideas, not a new...
Role of therapeutic patient education in preventing complications of chronic diseases in sub-Saharan Africa: a narrative review of the literature
This review looks at how teaching patients about their health helps prevent problems. It focuses on sub-Saharan Africa. It is a summary of other studies, so there are no new...
Nutritional Programming via Maternal Protein Restriction Mitigates Long-Term Consequences of Acute Kidney Injury
This study used rats to see if a mother's diet affects her baby's kidneys. It found that a low-protein diet during pregnancy may protect the baby's kidneys from long-term damage....
THE IMPORTANCE OF WATER, SHADE AND REST IN PREVENTING KIDNEY INJURY AMONG WORKERS IN HOT CONDITIONS
This is a conference summary about how to protect workers from kidney damage in hot weather. It says that providing water, shade, and rest breaks is key. There are no new results...
Can a person with chronic kidney failure eat protein-enriched foods?
This is a short note about whether people with kidney failure can eat high-protein foods. It says there is no direct evidence, and guidelines suggest avoiding high protein. There...
Can a person with chronic kidney failure take protein supplements?
This item is a data file, not a full study. It discusses how protein supplements might help keep muscle mass in people with kidney failure. There are no new results to report here.
Satellite-Measured Cyanobacterial Bloom Intensity and Kidney and Liver Disease Mortality Across U.S. Counties: analysis code and derived data
This is a file of computer code and data. It supports a study on how algae blooms in water might link to kidney and liver deaths. There are no new results in this file itself.
Microplastics and the Kidney: A Narrative Review of Human Evidence, Molecular Mechanisms of Cell Injury, and Future Directions
This is a review of existing research on microplastics and the kidney. It looks at how tiny plastic particles might hurt kidney cells. It summarizes what is known but does not...
Exerkines in Cardiovascular-Kidney-Metabolic Syndrome: An Integrative Framework for Mechanisms and Therapeutic Implications-A Narrative Review.
This review looks at how chemicals released by muscles during exercise affect the heart, kidneys, and metabolism. It connects these signals to a condition called CKM syndrome,...
Effectiveness of Inspiratory Muscle Training in CKD With Cardiogenic Pulmonary Edema: A Case Series
People with kidney disease and fluid in their lungs did breathing exercises. This training helped them breathe better and feel less short of breath. The study was very small, so it...
Scalable generation of human stem cell-derived ureteric bud and collecting duct organoids in stirred bioreactors.
Researchers found a way to grow small kidney tissues in a lab. They used a machine that stirs the cells to help them grow. This was done in a lab, not in people yet. It may help...
CRISPR screening identifies TWIST1 as a ferroptosis driver in CKD progression
This study used a gene-editing tool to find a gene that drives kidney damage. It is a new finding, but we do not have the full details yet. There are no results to report from this...
A renal cyst-clear cell renal cell carcinoma comorbidity analysis identifies a FOXM1-positive epithelial COL6A1-CD44 axis that remodels fibroblasts
This study looks at how kidney cysts and kidney cancer might be linked. It identifies specific proteins involved. There are no results yet because the full text is not available.
Prognostic Factors for Failure After Surgical Reconstruction of Adult Acquired Benign Ureteral Strictures: A Systematic Review and Meta-analysis
This review combined data from many studies on a surgery to fix narrowed tubes that carry urine. It looks at what factors make the surgery fail. This is a strong type of evidence...
An Interpretable Machine Learning Framework for Early Chronic Kidney Disease Prediction using XGBoost and SHAP
This is a technical paper about using computer programs to predict early kidney disease. The record does not include an abstract, so the specific results are not available here. It...
The cross-cultural and chronological evolution of the kidney-bone relationship: from ancient medical insights to modern molecular endocrinology
This review looks at how the link between kidneys and bones has changed over time. It covers ancient ideas and modern science. There is no abstract, so we do not have specific new...
Renal Complications After Pediatric Hematopoietic Stem Cell Transplantation: A Retrospective Cohort Study
This study looked at 70 children who had bone marrow transplants. It tracked kidney problems for two years. It shows a link between the transplant and kidney injury, but it is not...
Donor kidney volume relative to recipient body size and longitudinal graft function in living donor kidney transplantation
This is a published article about how the size of a donor kidney affects how well it works in a recipient. The record does not include an abstract, so the specific results are not...
[Chinese guidelines for the treatment and evaluation of IgG4-related disease (2026 edition)].
This is a set of rules for treating a rare immune disease. It is a guideline, not a new study. There are no new results here. It helps doctors know how to treat the disease.
Renal cell carcinoma with pancreas and splenic metastases
This is a case report about a person with kidney cancer that spread to the pancreas and spleen. It describes the imaging findings. There are no results yet because the full text is...
Pancreas metastases from renal cell carcinoma (MRI)
This is a case report showing MRI images of kidney cancer that spread to the pancreas. It helps doctors recognize this pattern. There are no results yet because the full text is...
Undiagnosed Stroke and Neurological Manifestations in Chronic Kidney Disease: A Case Series
This report looked at 39 people with kidney disease who were in the hospital. It describes brain scans and nerve problems found in these patients. The study shows a link between...
Phacoemulsification With Advanced Monofocal Iol Implantation In Chronic Kidney Disease(Ckd) Patients Undergoing Dialysis -A Retrospective Study
This is a conference abstract about eye surgery for people with kidney disease on dialysis. The record does not include an abstract, so the specific results are not available here....