← brief for 2026-10-11 · Slowing decline

A randomized trial of high versus low serum bicarbonate targets and glomerular filtration rate decline in stage 3–4 chronic kidney disease

Key takeaways

This trial tested if a higher target for blood bicarbonate levels slows kidney decline. It involved 58 people with stage 3 or 4 kidney disease over 104 weeks. The study found that the higher target did not slow the decline compared to the lower target.

Who did this work

Martina Gaggl (Medical University of Vienna) · Christof Aigner (Medical University of Vienna) · Alexandra Repitz (Medical University of Vienna) · Sonja Riesenhuber (Medical University of Vienna) · Christopher Sliber (Medical University of Vienna) · Moritz Madern (Medical University of Vienna) · Andreas Gleiß (Medical University of Vienna) · Melanie Fraunschiel (Medical University of Vienna) · Alice Schmidt (Medical University of Vienna) · Gere Sunder–Plassmann (Medical University of Vienna)

Source

Article · OpenAlex, CKD works · 2026-10-10
https://doi.org/10.1038/s41598-026-68492-9