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FTO-mediated m6A modification of EGR1 mRNA promotes podocyte injury and inflammation via STING1 in diabetic kidney disease

Article D Peer reviewed Preclinical

Key takeaways

This study looked at kidney cells in the lab and in people with diabetes. It found that a specific protein change can damage the tiny filters in the kidney. This was in cells and tissue samples, not a test in people yet.

Who did this work

Jinxiu Hu (Shandong University) · Yue Liu (Shandong Provincial Hospital) · Yating Lang (Shandong Provincial Hospital) · Bing Liu (Shandong Provincial Hospital) · Xiaoting Fan (Shandong Provincial Hospital) · Meilin Yang (Shandong Provincial Hospital) · Ning Shen (Shandong Provincial Hospital) · Dongdong Zhang (Shandong Provincial Hospital) · Xia Zhang (Shandong Provincial Hospital) · Shouyu Chai (Shandong Provincial Hospital) · Zhitao Zeng (Shandong Provincial Hospital) · Jiazhen Shang (Shandong Provincial Hospital)

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-10-10
https://doi.org/10.1007/s00018-026-06474-w