Kidney research, 2026-10-03
Doctors are not using kidney-protecting diabetes drugs as often as they should.
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Other reports today were mostly small case studies or observational data, so they do not prove new treatments work.
Today's news focuses on how doctors currently treat patients rather than new drug trials. The main finding is that many patients with heart disease are missing out on diabetes drugs that can also protect the kidneys. This is an observational study, so it shows a gap in care but does not prove the drugs work better than other options. No major new clinical trials for kidney disease were reported today.
Association between renal vascular lesions and echocardiographic indices related to diastolic function in patients with diabetic nephropathy: a biopsy-based cross-sectional study.
This study looked at 360 people with kidney damage from diabetes. It found a link between kidney blood vessel damage and heart function. This is an observational study, so it shows...
Unraveling cardiac amyloidosis in Egypt: diagnostic challenges and disease outcomes.
This study describes how a heart disease called amyloidosis looks in patients in Egypt. It is an observational study, so it shows a link, not proof of cause.
Hyperinflammatory nutritional index as an exploratory combined inflammatory and nutritional marker: associations with cytokines and β2-microglobulin in COVID-19.
This study checked if a new score for inflammation and nutrition links to kidney markers in people with COVID-19. It is an observational study, so it shows a link, not proof of...
Associations Among Glycemic Variability, Hypomagnesemia, Thyroid Function, and Albuminuria in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study.
This study looked at how blood sugar swings, low magnesium, and thyroid issues link to protein in the urine. It is an observational study, so it shows a link, not proof of cause.
Growth Differentiation Factor 15 Is Associated with Severe Coronary Artery Calcification in Patients with Chronic Kidney Disease
This study found that a blood marker called GDF-15 is linked to hardening of the heart arteries in 128 people with kidney disease. This is an observational study, so it shows a...
In patients on peritoneal dialysis with advanced chronic kidney disease, do ACE inhibitors or ARBs preserve residual renal function or improve clinical outcomes compared to no treatment?
This item asks if blood pressure drugs help people on dialysis keep some kidney function. It is a question or a plan, not a finished study. There are no results yet.
CLINICAL AND PATHOGENETIC RATIONALE FOR THE COMBINED USE OF FINERENONE AND EMPAGLIFLOZIN IN PATIENTS WITH DIABETIC NEPHROPATHY AND IMPAIRED RENAL FUNCTION
A trial is planned to test two drugs together for diabetic kidney disease. The study will include 120 people. There are no results yet because the trial is just starting.
Integrated morphological and transcriptomic analysis of bone disorders in aldosterone-salt hypertension
Rats given high salt and a hormone had bone damage. A drug called esaxerenone helped protect their bones. This was done in animals, not people yet.
Blood-pressure sampling resolution and the intraoperative hypotension-acute kidney injury association (MOVER, VitalDB and INSPIRE)
This item shares code and plans for a study on low blood pressure during surgery. It looks at how often blood pressure is checked. There are no results yet.
Bone Anabolic Treatment in Patients With Chronic Kidney Disease: A Systematic Review
This review looked at bone-building drugs for people with late-stage kidney disease. It found that the evidence for these drugs is still limited. More studies are needed to see if...
From Susceptibility Loci to Therapeutic Targets: The Genetic Architecture of IgA Nephropathy
This review looks at the genes behind IgA nephropathy. It is a common cause of kidney failure in young adults. The review maps these genes to how the disease works. This helps find...
Group IVA Cytosolic Phospholipase A2 (cPLA2α): Pharmacological Inhibition Attenuates Kidney Inflammation and Fibrosis
This study tested a drug on animals with kidney disease. It blocked an enzyme that causes inflammation and scarring. The drug slowed the damage in the animals. This was not tested...
TMEM174 deficiency reduces longevity by promoting phosphate-driven vascular calcification
This study used mice to look at a protein called TMEM174. Mice without this protein lived shorter lives and had more hardening in their blood vessels. This was in animals, not...
Alterations of Gene Expression and Signaling Pathway Activity in Venous Smooth Muscle Cells After Uremic Serum Exposure
This study looked at cells from pig veins that were exposed to blood from people with kidney failure. It found changes in how the cells worked. This was in cells, not people yet....
Establishment of an Animal Model of Type 2 Cardiorenal Syndrome
Researchers created a new animal model to study how heart problems cause kidney damage. They used a two-step method in animals to mimic the disease in people. This is a preclinical...
Gout in North America
This review looks at how common gout is in North America. It shows a link between rising obesity and more cases of gout in young people. It also notes that Black patients face...
Emerging Roles of FGFR3 and FGF23-Associated Signaling in Renal Fibrosis: Molecular Integration, Clinical Correlates, and Therapeutic Perspectives
This review looks at how certain proteins cause scarring in the kidney. It focuses on lab studies using cells and animals to understand the disease. The evidence is mostly...
Tangerine Peel Polysaccharide Alleviates High-Fat Diet-Induced Renal Lipotoxicity in Association with Gut Microbiota Remodeling in Mice
Mice fed a high-fat diet were given a compound from tangerine peel. The compound reduced fat buildup and scarring in the kidneys of the mice. This is a preclinical study, so it was...
Kidney Function Trajectories in Patients with and Without Chronic Kidney Disease Undergoing Transcatheter Aortic Valve Replacement: A Single-Retrospective Cohort Study
This study looked at 314 people who had a heart valve procedure. It tracked how their kidney function changed over time after the surgery. It is an observational study, so it shows...
From high-salt diet to cancer immunity: gut microbiota and immune system interactions and their mechanisms
This review looks at how a high-salt diet affects the immune system. It suggests salt may change gut bacteria and how the body fights disease. It is an observational review, so it...
Sequencing and combination of therapies in the cardiovascular-kidney-metabolic syndrome: GLP-1 RA, SGLT2 inhibitors, lipid-lowering drugs and mineralocorticoid receptor antagonists
This review discusses how to combine different drugs for heart and kidney disease. It looks at evidence from large studies to guide treatment order. It is a review of observational...
Real-world prescribing patterns of SGLT2 inhibitors and GLP-1 receptor agonists in Type 2 diabetes with various ASCVD subtypes from a large tertiary referral center.
This study checked how often doctors prescribe two types of diabetes drugs to patients with heart disease. It looked at records from one large hospital system. This is an...
Uremic Optic Neuropathy as the Initial Manifestation of Advanced Chronic Kidney Disease.
This is a report on one man who had vision problems before his kidney failure was found. His eyes swelled because of toxins in his blood. This is a single case report, not a large...
Blood Glucose Management Behaviour Among Haemodialysis Patients with Diabetes: A Qualitative Study Guided by the Theory of Planned Behaviour.
This study interviewed 12 people on dialysis to understand why they manage their blood sugar the way they do. It is a qualitative study, so it shows a link, not proof of cause.
The interplay of the gut microbiome, tryptophan metabolites, and uremic toxin generation in chronic kidney disease progression
This review explains how gut bacteria make toxins that can hurt the kidneys. It links the food we eat to kidney decline. This is a review of existing science, not a new trial with...
Nutritional Status, Biochemical Parameters, Dietary Intake, and Factors Associated with Obesity among Hemodialysis Patients in Morocco
This study looked at diet and body weight in dialysis patients in Morocco. It found a link between obesity and certain health markers. This shows a connection, but it does not...
Systematic review of clinical guidance for lipid management in adults with or at risk of atherosclerotic cardiovascular disease: A global perspective.
This review summarizes global medical guidelines for managing cholesterol. It covers patients with diabetes, kidney disease, and obesity. It is a review of existing rules, not a...
Biopsychosocial phenogroups in an urban population with coronary artery disease and their associations with adverse cardiovascular events.
This study grouped 949 people with heart disease based on stress and heart health. It is an observational study, so it shows a link, not proof of cause.
Depression and Chronic Hemodialysis A Study of Associated Factors in Morocco
This study surveyed 200 people on dialysis in Morocco. It found that 80% of them had depression. It is an observational study, so it shows a link, not proof of cause. It highlights...
Dreaming, sleep quality, and psychological distress among patients with chronic kidney disease at a national nephrology hospital in Sri Lanka: a descriptive cross-sectional study
This study surveyed 422 people on dialysis in Sri Lanka about their sleep and dreams. It found links between poor sleep and high stress. It is an observational study, so it shows a...
Tonicity drives collecting duct maturation in the mammalian kidney.
Researchers found that high salt levels help kidney cells mature in the lab. This was done in cells and animals, not people yet. This finding could help build better kidney...
Circ_0000745 Attenuates Sepsis-Induced Acute Kidney Injury Via the MiR‑671‑5p/IGFBP3 Axis, with Associated Changes in Autophagy-Related Markers
This article looks at how certain molecules in the body might protect kidneys during a severe infection. It is a published paper, but we do not have the full text to see the...
Acute kidney injury-to-chronic kidney disease transition: Maladaptive senescence, epigenetic reprogramming, and the translational frontier
This review explains how a sudden kidney injury can turn into long-term kidney disease. It describes how cells stop repairing themselves and start to age. This is a review of...
The landscape of allele-specific expression in human kidneys
Researchers mapped how genes work in kidney tissue from people with disease. They found that sick kidneys show more gene activity in the filtering parts. This was a lab study of...
From Breath‐Hold to Free‐Breathing: Possibilities in High‐Resolution Quantitative Susceptibility Mapping ( QSM ) of the Kidney With Respiratory Gating
Researchers tested a new kidney imaging method on 15 healthy people. They used a special tool to track breathing and reduce motion blur. The study showed that this method works...
Proteomics of highly post-translationally modified proteins in kidney tubulointerstitium
This study looked at proteins in kidney tissue. It focused on how these proteins change during scarring. This was done in the lab, not in people yet. It helps us understand how...
Patency and functional outcomes of endovascular treatment in juxta-anastomotic venous stenosis of native arteriovenous fistulas.
This study looked at how well dialysis access points stay open after a minor procedure. It tracked patients at one center over several years. This is an observational study, so it...
Vasoconstrictor therapy for HRS-AKI in patients listed for liver transplantation: Translating evidence to the pretransplant setting
This review looked at 127 studies on a drug called terlipressin. It is used to treat a type of kidney injury in people with severe liver disease. The review found that starting...
Association of diabetes medication adherence quality measure performance with A1c control among Medicare Advantage beneficiaries.
This study checked if insurance plans that score well on diabetes care also have patients with better blood sugar control. It is an observational study, so it shows a link, not...
Component-level associations of anemia and renal dysfunction with competing first events in acute heart failure with atrial fibrillation
This article is about heart failure and kidney function. It is a published paper, but we do not have the full text to see the results yet.
Potential clinical benefits of early belumosudil treatment in chronic graft-versus-host disease
This article discusses a drug for a condition that often happens after a bone marrow transplant. It is a published paper, but we do not have the full text to see the results yet.
Health technology assessment of long-acting erythropoiesis-stimulating agents for the treatment of renal anemia in China
This study evaluates drugs that treat low blood counts in people with kidney disease. It looks at how these drugs are used in China. This is an assessment of drug use, not a...
Subclinical hepatorenal biomarker alterations and urogenital indicators in Schistosoma haematobium-infected School-Aged Children in Sene West District, Ghana
This is a preprint about children in Ghana who have a parasite infection. It looks at how the infection affects their liver and kidneys. It has not been peer reviewed yet.
Correction: Immunogenicity of ChAdOx1 nCoV-19 vaccine after a two-dose inactivated SARS-CoV-2 vaccination of dialysis patients and kidney transplant recipients
This is a correction to a previous paper about vaccines for people on dialysis. It fixes small errors in the original text. It does not report new study results.
Inteligência Artificial na Hemodiálise: Monitoramento e Qualificação do Cuidado ao Paciente Renal
This review discusses how artificial intelligence can help monitor people on dialysis. It looks at how AI can spot risks and support care. There are no new results from a trial in...