← brief for 2026-10-03 · Regeneration & devices

The landscape of allele-specific expression in human kidneys

Article D Peer reviewed Preclinical

Key takeaways

Researchers mapped how genes work in kidney tissue from people with disease. They found that sick kidneys show more gene activity in the filtering parts. This was a lab study of tissue, not a test of a new drug in people.

Who did this work

Ana C. Onuchic-Whitford (Broad Institute) · Junmo Sung (Broad Institute) · Eric D. Sakkas (Broad Institute) · Michelle T. McNulty (Broad Institute) · Victoria Mezger (Broad Institute) · Christopher Lund O'Connor (University of Michigan) · Anya Greenberg (Broad Institute) · Jihoon G. Yoon (Boston Children's Hospital) · Sowmya Badina (Boston Children's Hospital) · Laura H. Mariani (University of Michigan) · Markus Bitzer (University of Michigan) · Matthew Gordon Sampson (Broad Institute)

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-10-02
https://doi.org/10.1126/sciadv.aeg3462