← brief for 2026-10-03 · Slowing decline

TMEM174 deficiency reduces longevity by promoting phosphate-driven vascular calcification

Key takeaways

This study used mice to look at a protein called TMEM174. Mice without this protein lived shorter lives and had more hardening in their blood vessels. This was in animals, not people yet. It suggests this protein helps protect blood vessels in kidney disease.

Who did this work

Jose Guadalupe Miranda (University of Colorado Anschutz) · Judith Blaine (University of Colorado Anschutz) · Makoto Miyazaki (University of Colorado Anschutz)

Source

Article · OpenAlex, CKD works · 2026-10-02
https://doi.org/10.1038/s41598-026-74353-2