Kidney research, 2026-09-28
New data shows exercise and drug safety for kidney patients.
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A review looked at kidney transplants for people born with heart defects to help doctors plan care.
Today's news focuses on practical care for people with kidney disease. Researchers looked at how exercise affects blood fats and how new drugs work in damaged kidneys. These studies help doctors make safer choices for treatment and daily habits.
Explainable Artificial Intelligence for Early Diabetic Kidney Disease Risk Profiling in Type 2 Diabetes: Translational Readiness and Clinical Boundaries.
This review looks at how computer tools can help doctors spot early kidney damage in people with type 2 diabetes. It explains how these tools work and where they might be useful in...
Linagliptin increases the expression of LRP2 independent of Nrf2 in streptozotocin-induced diabetic mice.
This study used mice to test a diabetes drug called linagliptin. It looked at how the drug affects cells in the kidney. The study found the drug changed certain proteins in the...
Kidney function parameters in South African children living with HIV on antiretroviral therapy.
This study followed 220 children with HIV and 220 without. It tracked their kidney health over about 3.7 years. It shows a link between HIV and kidney function, but it is not proof...
Empagliflozin Promotes Natriuresis in Diabetic Patients with Cirrhotic Refractory Ascites: A Proof-of-Concept Study.
This small test looked at a diabetes drug called empagliflozin. It was given to people with liver disease and fluid buildup in the belly. The drug helped the body shed salt through...
Effectiveness of Finerenone in Slowing Chronic Kidney Disease Progression After Hospitalization for Heart Failure: A FIDELITY Subgroup Analysis.
This analysis pooled data from two large randomized trials of finerenone. It looked at people with kidney disease and type 2 diabetes who were hospitalized for heart failure. It...
Tirzepatide Initiation in Lithium-Treated Bipolar Disorder: Renal Biomarker Trajectories and Lithium Safety Signals Over 12 Months in a Real-World Cohort.
This study followed 23 adults taking lithium for bipolar disorder. They started a new drug called tirzepatide. The study looked at kidney markers over 12 months. It is...
Targeting the aldosterone–mineralocorticoid receptor pathway in cardiovascular–kidney–metabolic syndrome
This is a review article, not a new trial. It discusses evidence that blocking the aldosterone pathway can help people with combined heart, kidney, and metabolic disease. It...
Correlation of PON1 rs662 gene polymorphism, Serum Paraoxonase 1 and Calprotectin levels in Chronic Kidney Disease patients in Northern India
This study looked at 240 people in India, half with kidney disease. It checked if a specific gene change linked to higher levels of certain proteins. The study shows a link between...
Red cell distribution width-to-albumin ratio predicts AKI and mortality in colorectal cancer critically ill patients
Researchers studied 706 critically ill patients with colorectal cancer. They used a blood test ratio to predict who would get sudden kidney injury. The study shows a link between...
HCV-Related Cryoglobulinemic Glomerulonephritis with Complete Renal Recovery after Combined Therapy
This is a report on one 51-year-old man. He had kidney damage from a virus and a specific immune reaction. He received a mix of virus-fighting drugs and immune-suppressing drugs....
Development of a monoclonal antibody targeting the calcification blocking factor CBF
Researchers built a new test to measure a protein called CBF. This protein helps stop blood vessels from hardening, which is a common problem in kidney disease. The study focused...
Prognostic value of hemoglobin-to-serum creatinine ratio in patients with coronary artery disease and reduced kidney function following percutaneous coronary intervention
This study checks a blood test ratio in heart and kidney patients. It aims to predict health outcomes after a heart procedure. There is no abstract, so we do not have the study...
Hyperglycaemia-induced molecular reprogramming of proximal tubular epithelial cells and its contribution to diabetic kidney disease progression—a narrative review
This review explains how high blood sugar changes kidney cells. It looks at how this damage leads to kidney disease. There is no abstract, so we do not have the study results yet.
COVID-19 and subsequent risk of coded diabetic retinopathy in patients with type 2 diabetes: a multicenter propensity score-matched cohort study
This study looks at eye damage in people with type 2 diabetes. It checks if having COVID-19 raises the risk of this eye problem. There is no abstract, so we do not have the study...
Prognostic Value of Standard Base Excess in Sepsis-Associated Acute Kidney Injury: A Retrospective Cohort Study.
A large review of 16,842 patients found that a blood test called base excess can predict who will die from severe kidney failure caused by infection. This shows a link, not proof...
Urinary metabolomics profile in children with ureteropelvic junction obstruction.
This pilot study looks at urine from children with a blockage in their kidney. It is a small test to find new markers. There are no final results yet.
Anp32e mediates histone variant H2A.Z-regulated TGF-β1 involvement in renal interstitial fibrosis.
This study looked at kidney cells in a lab model of scarring. It found that a protein called Anp32e plays a role in how the cells respond to a signal that causes scarring. This...
Natural product therapy in diabetic kidney disease: emerging multiomics-mediated signalling pathway and molecular target.
This review looks at how natural products might help treat diabetic kidney disease. It discusses how these substances interact with the body's systems at a molecular level. This is...
Glycated albumin: An old yet new biomarker in people with diabetes and the potential for novel applications.
This review discusses a blood test called glycated albumin. It measures blood sugar levels over about two weeks. The authors explain why this test is useful for people with kidney...
Studying the Comorbidity of Impaired eGFR With Diabetes, Hypertension, and Cardiovascular Diseases in the Tabari Cohort Population.
This study looked at a group of people in Iran to see how kidney function relates to other health issues. It found that people with lower kidney filtering rates often also had...
Tibial Artery Stenting in the VQI Database.
This study looked at records of people who had procedures to open blocked leg arteries. It compared using a small metal tube, called a stent, against using a balloon to widen the...
Risk Stratification by eGFR < 45 mL/min/1.73 m(2) for All-Cause Mortality in Patients With Diabetic Foot Ulcer: A Multidisciplinary Retrospective Cohort Study.
Researchers looked at 595 people with diabetic foot ulcers. They checked how kidney function affected their survival. The study shows a link between low kidney function and higher...
Effects of automated peritoneal dialysis and continuous ambulatory peritoneal dialysis on residual kidney function in Chinese patients with new-onset end stage kidney disease.
This study followed 53 people who just started dialysis. It compared two types of dialysis to see which one protects remaining kidney function. The study shows a link between the...
VITAMIN D AND CHRONIC KIDNEY DISEASE ASSOCIATION WITH MINERAL AND BONE DISORDER: AN APPRAISAL OF TANGLED GUIDELINES
This paper reviews the rules for treating vitamin D in people with kidney disease. It notes that the guidelines are confusing. It discusses the risks of low vitamin D, but it does...
PTBP3 promotes diabetic nephropathy via Smad3-dependent podocyte-mesenchymal transition
This article looks at a protein called PTBP3. It is linked to kidney damage in people with diabetes. The record does not include the study details or results, so there is no data...
Association of Metabolic Syndrome with Early Renal Dysfunction in Patients with Type 2 Diabetes Mellitus: A Hospital-Based Cross-Sectional Study.
Researchers looked at 204 adults with type 2 diabetes in Pakistan. They checked for early signs of kidney trouble, like protein in the urine. This study shows a link between...
Cardiovascular and kidney outcomes of semaglutide and the annual eGFR slope in adults with and without type 2 diabetes: data extraction sheet, analysis code and search records for a systematic review and meta-analysis of randomised controlled trials
This is a data file for a review of semaglutide, a diabetes drug. It is not the main study. There are no new results to report yet.
Alpha-Klotho, FGF-23, and Calcium-Phosphate Product Across Renal Function Strata in Chronic Heart Failure: Associations with Cardiac Remodeling and Six-Month Treatment Response
This study looked at blood markers in people with heart failure. It found a link between kidney function and heart changes. It shows a link, not proof of cause.
Anti-GBM disease shortly after clinically presumed ANCA-associated vasculitis in an 85-year-old patient: a case report and literature review
This report describes an 85-year-old woman with two rare kidney diseases. She was treated for one, but the other appeared later. It is a single case, so it does not prove a cause...
Albuminuria, kidney function, and automatically quantified retinal vascular phenotypes in hospitalized adults with type 2 diabetes
This study checked if eye scans could show kidney damage in people with type 2 diabetes. It found links between eye blood vessel patterns and kidney markers. This is an...
Case Report: Fabry cardiomyopathy associated with a novel truncating GLA variant, c.837_838delinsAT, p.(Gln280Ter)
This report describes one woman with a rare genetic condition called Fabry disease. Her heart muscle was thickened and scarred. The study identifies a new gene change linked to her...
Effectiveness of Adding GLP-1 Receptor Agonists to SGLT2 Inhibitor Therapy in Chronic Kidney Disease: A Population Based Study.
This study looked at people with chronic kidney disease. It compared taking one diabetes drug to taking two. It checked for major kidney and heart events. It shows a link between...
Does higher kidney risk justify more finerenone? Reappraising absolute benefit against the safety window of FINEARTS-HF.
This is an opinion piece about a heart failure drug called finerenone. It discusses whether people with kidney disease should take it. It argues for a careful look at the benefits...
Dapagliflozin Alone or Combined With Semaglutide: Cardiovascular and Renal Outcomes Among Patients With Type 2 Diabetes Mellitus in a 6-Month Real-World Retrospective Cohort Study in Saudi Arabia.
This study looked at 539 people with type 2 diabetes. It compared one diabetes drug to a combination of two drugs. It checked heart and kidney health. It shows a link between the...
Data from the French Daily-Luma cohort suggest predictors of a lumasiran response
This study looked at a rare kidney disease called Primary Hyperoxaluria type 1. It checked if a person's genes predict how well a drug called lumasiran works. The study found a...
https://www.theisn.org/blog/2026/09/28/isn-international-expert-forum-explores-complement-therapeutics-in-clinical-practice/
The International Society of Nephrology is hosting an expert forum on new kidney drugs. These drugs target the body's immune system to stop damage. The post announces the event but...
Prevalence and significance of family history of kidney disease in the electronic health record in three United States health systems
This study checked medical records in three US health systems. It looked at how often family history of kidney disease was recorded. The study found that this history is a key...
Prospective 96-week study to evaluate efficacy and safety of tacrolimus and glucocorticoid against mycophenolate and glucocorticoid as continuous induction-maintenance treatment for Class III/IV without or with Class V lupus nephritis
This is a large trial in Asia testing a specific drug mix for lupus kidney disease. It compares two standard treatments over 96 weeks. The record describes the study plan, but it...
Changes in renal function in patients with chronic kidney disease after ureteroscopy: a systematic review and meta-analysis from EAU endourology.
This review combined data from many studies to see if kidney stone surgery hurts kidney function. It focused on people who already had chronic kidney disease. The analysis suggests...
Risk factors for recurrent urinary tract infection after SGLT2 inhibitor reinitiation in type 2 diabetes.
This study looked at 316 people with type 2 diabetes who restarted SGLT2 drugs after a urinary tract infection. It found that some patients had a higher chance of getting another...
An audit of the fracture liaison service at Helen Joseph Tertiary Hospital, Johannesburg, South Africa.
This study checked how well a hospital program helps people with broken bones. It found that many patients had risk factors for weak bones. The study shows a link between the...
Safety profile of Finerenone: Pooled analysis of different types of arrhythmic events.
This letter reviews six large trials to check if a kidney drug causes heart rhythm problems. It found that the drug did not increase the risk of these issues. This is a summary of...
EASL-EASD-EASO Guidance for the Use of Resmetirom and Semaglutide as MASH-Targeted Therapy.
This is a set of medical guidelines for treating a type of fatty liver disease. It gives doctors advice on when to use two specific drugs. This is a recommendation, not a new study...
Pharmacokinetics, safety, and tolerability of ceftibuten-ledaborbactam etzadroxil in participants with renal impairment.
This study tested a new antibiotic mix in people with different levels of kidney damage. It checked how the body handles the drug and if it is safe. The text does not say how many...
Diabetic kidney disease: emerging mechanistic and nutritional perspectives from the Mediterranean diet-mitochondria axis. A narrative review.
This review looks at how the Mediterranean diet may help kidney health in people with diabetes. It suggests the diet supports the tiny energy makers in kidney cells. It is a review...
Analgesic Efficacy of Mirogabalin in Patients With Herpes Zoster: Protocol for a Prospective Multicenter Randomized Open-Label Blinded-Endpoint (PROBE) Study.
This is a plan for a new study on a pain drug called mirogabalin. The study will test if this drug helps with pain from shingles. There are no results yet because the study is just...
Losing Muscle or Restoring Physiology? Reframing the Incretin Therapy Sarcopenia Concern.
This is an opinion piece about weight-loss drugs. It argues that losing some muscle is a normal part of losing weight. It is not a new study with data, but a discussion of existing...
Non-Pharmacological Interventions for Sleep Quality and Related Symptoms in Patients with End-Stage Renal Disease: A Systematic Review and Meta-Analysis.
This review combined many trials on sleep help for people on dialysis. It found that non-drug methods improved sleep quality. These methods also lowered anxiety and depression...
Objective and Subjective Multidimensional Sleep Health in Women After Myocardial Infarction.
This study looked at sleep in women who had a heart attack. It found links between poor sleep and other health factors. It shows a connection, not proof that sleep causes these...
Psychological intervention for disputing irrational beliefs associated with work stress amongst tourism educators and mathematicians with hypertension.
This study involved 93 university staff with high blood pressure. It tested if a type of talk therapy could lower their work stress. The study is small, so the results are not yet...
A Patient- and Function-Centric Model/Approach for Hypoglycemia Management in Older Adults.
This review looks at how to manage low blood sugar in older adults. It notes that kidney problems can change how the body handles sugar. It is a general guide, not a new study with...
Prenatal Mindfulness Training and Race-Related Vigilance: A Mixed-Methods Study Among Pregnant Women at Risk for Hypertensive Disorders.
This study looked at 53 pregnant women of color who were at risk for high blood pressure. It tested if mindfulness training helped them handle stress from discrimination. The study...
Psychosocial stress and risk of first-ever stroke: a systematic review and meta-analysis.
This large review found a link between high stress and a higher chance of having a stroke. It shows a connection, not proof that stress causes stroke. This is important because...
Dose–Response Relationships Between Exercise Modalities and Triglyceride Reduction in Adults: A Systematic Review and Model-Based Network Meta-Analysis
This review looks at how different types of exercise lower blood fats. It is a published paper, but the text provided has no abstract. So, we do not have the specific results to...
Non-Pharmacological Interventions for Sleep Quality and Related Symptoms in Patients with End-Stage Renal Disease: A Systematic Review and Meta-Analysis
This review looks at sleep help for people on dialysis. It is a key topic for kidney care, but there is no summary to read yet.
Multiscale signatures of cortical hierarchical alterations and dialysis-associated preservation in end-stage renal disease.
This study used brain scans to look at how the brain is organized in people with end-stage kidney disease. It compared people on dialysis, people not on dialysis, and healthy...
Targeting ALCAT1 Ameliorates Cardiomyopathy in Barth Syndrome
This study used mice to look at a rare heart condition. It tested a specific enzyme to see if it could help the heart muscle. The results were in animals, not people yet. It is a...
Polymyxin B Attenuates Sepsis-Induced Acute Kidney Injury by Activating a SUMO1-p65 "Molecular Brake" in Kidney Organoids.
This study used mouse kidney organoids and mice to test a drug called polymyxin B. It found the drug reduced inflammation in the kidney models. It was done in animals and cells,...
A colorimetric sensor array based on merging silver nanozymes and gold nanoparticles for chronic kidney disease diagnosis and post-transplant monitoring
This paper describes a new sensor tool for checking kidney health. It uses tiny particles to detect changes in the body. There is no abstract, so we do not have the study results...
An ROS‐Responsive CeO 2 –Selenium Nanozyme Mitigates Renal Injury via Coordinated Ferroptosis Inhibition and Inflammation Resolution
Researchers made a tiny particle that reacts to stress in kidney cells. It helped reduce damage in lab tests. This was done in cells, not in people yet.
Determinants of early acute kidney injury after robot-assisted partial nephrectomy: a single-institution analysis of a prospectively maintained cohort
This study looked at people who had part of a kidney removed by robot. It found that certain tumor features predicted a temporary drop in kidney function after surgery. This is an...
A colorimetric sensor array based on merging silver nanozymes and gold nanoparticles for chronic kidney disease diagnosis and post-transplant monitoring.
This study created a new blood test for kidney disease. It used tiny particles to change color when mixed with blood. The test worked on 120 samples in the lab. This was in the...
Podocyte GIT1 and GIT2 ArfGAPs cooperatively sustain the ARHGEF7-Cdc42 axis and glomerular permselectivity
This study looked at kidney cells in the lab. It checked how specific proteins help these cells keep their shape. The researchers found that these proteins work together to protect...
Tubular Rev-erbα deficiency aggravates kidney fibrosis via transcription factor NFIL3-driven lipid accumulation
This study looked at how the body's internal clock affects kidney scarring. It found that when a specific clock gene is missing, scarring gets worse. This was done in animals or...
The Polycystic Kidney Disease Cyst Transcriptome Defined by Integrating Spatial, Single Nuclear, and Bulk Transcriptomics.
This study used advanced lab techniques to map the genetic activity in kidney cysts. It was done in the lab using tissue samples, not in living people. This helps scientists...
CAR T cell targeting of inflammatory myeloid progenitors in the bone marrow remodels border-associated macrophages and reverses cognitive aging
This research used a type of cell therapy in mice to treat brain aging. The therapy helped restore memory and thinking skills in the animals. This work was done in mice, not...
Urinary Retinol-Binding Protein 4 as a Noninvasive Indicator of Tubular Ferroptosis in Diabetic Kidney Disease.
This study looked for a urine marker that shows a specific type of cell death in the kidneys. It used data from people and a mouse model to find this marker. This was in animals...
B3GALT5 regulates renal A/B antigen levels: a determinant of prognosis and rejection in ABO-incompatible kidney transplantation.
This study looked at 28 people who received kidney transplants from donors with different blood types. It checked how the donor kidney reacted to the recipient's blood. The study...
Prediction models for infection after kidney transplantation: a systematic review
This review looks at tools that predict infections after a transplant. It summarizes different models used by doctors. There is no abstract, so we do not have the study results...
B3GALT5 regulates renal A/B antigen levels: a determinant of prognosis and rejection in ABO-incompatible kidney transplantation
This study looks at a gene that affects kidney transplants. It may help predict if a new kidney will be rejected. There is no abstract, so we do not have the study results yet.
https://www.theisn.org/blog/2026/09/28/help-build-a-clearer-picture-of-international-travel-for-organ-transplantation/
The International Society of Nephrology is asking for help to track organ travel. This aims to make it clearer when organs move between countries. The post is a call for data and...
Renal transplantation in congenital heart diseases: A systematic review of outcomes and challenges.
This review looked at kidney transplants for people born with heart defects. It gathered data from many studies to see how well the new kidneys work. It also checked for problems...
Clinical Pharmacy Services among Veterans with Chronic Kidney Disease: Associations with Rural Residence and Primary Care Setting.
This large study looked at 699,273 veterans with kidney disease. It checked who got help from a clinical pharmacist. It found that about 18% of urban veterans and 17% of rural...
https://www.theisn.org/blog/2026/09/28/get-ready-for-wcn27-3-ways-to-take-action-now/
This is a blog post from the International Society of Nephrology. It gives three ways to get ready for their 2027 World Congress. There are no study results in this post.
https://www.theisn.org/blog/2026/09/28/wkd-2027-campaign-launches-with-new-challenge-and-grant-program/
The International Society of Nephrology launched a new campaign for World Kidney Day 2027. It includes a new challenge and a grant program. This is an announcement about upcoming...
Barriers and Facilitators to Returning to Work Among Middle-aged and Young Adults with End-stage Renal Disease: A Qualitative Study
This study interviewed 23 people with kidney failure to understand what stops or helps them return to work. The researchers looked at patients on dialysis or those who had a...
Prevalence and Predictors of Nonadherence to Treatment in Adult Patients Undergoing In-Centre Haemodialysis in Public Dialysis Units: A Quantitative Cross-Sectional Study.
In Bahrain, 266 people on dialysis were surveyed. Many did not follow their treatment plans. This shows a link between skipping care and health risks, but it is not proof of cause.
Evaluating the reliability and quality of lupus nephritis educational content on TikTok and Bilibili: a cross-sectional content analysis.
This study checked how good kidney health videos are on social media. It is about information quality, not new treatments. There are no new medical results.
Ultrasonographic Features of the Kidney in Patients With Frasier Syndrome and Stage 5 Chronic Kidney Disease: A Case Report and Literature Review.
This report describes one 12-year-old boy with a rare genetic condition. It details how his kidneys looked on an ultrasound. It is a single case, so it does not provide general...
Mean Arterial Pressure, Forward Flow, and Right‐Sided Hemodynamics During the First 24 h of Monitoring After HeartMate 3 Implantation
Researchers watched blood pressure in people who got a HeartMate 3 heart device. They looked at the first 24 hours after surgery. The study found a link between blood pressure and...
Assessing the impact of dialysis on short, intermediate, and long-term outcomes following total hip arthroplasty: a propensity-matched analysis
This study compared hip replacement results in people on dialysis versus those who are not. It used a large database to match the groups. The results show a link between dialysis...
MLN4924 suppresses kidney renal clear cell carcinoma progression through coordinated inhibition of Cullin1 neddylation and PSMB10-associated NF-κB inflammatory signaling
This article describes a drug called MLN4924. It is being studied for its effect on a type of kidney cancer. The record does not include the study details or results, so there is...
Combined Transarterial Embolization and Percutaneous CT-Guided Cryoablation of Renal Cell Carcinoma: A Retrospective Single-Center Study
This is a published article about treating kidney cancer. It has no abstract, so we have not read the study. There are no results to report yet.
Replication archive: Exposure and outcome construction shape reported associations of urinary metal mixtures with chronic kidney disease — a specification-curve analysis of NHANES 2005–2018
This is a data file for a study on metals in urine and kidney disease. It is not a full study. There are no new results to report.
Derived data for "Coverage-aware renal ion transportome reprogramming in acute kidney injury and chronic kidney disease"
This is a data file for a study on kidney cells. It is not a full study. There are no new results to report.
Rectus sheath hematoma in autosomal dominant polycystic kidney disease: a case series
This is a small report of people with a kidney disease who had a belly bleed. It shows a link, not proof of cause. It is a case series, not a large trial.
Lactate in acute kidney injury: pathobiology, risk stratification, and clinical interpretation
This is a published article about a blood marker in sudden kidney injury. It has no abstract, so we have not read the study. There are no results to report yet.
What effect does IgM MGUS have on the kidneys and what monitoring is appropriate?
This item is a data file, not a full study. It discusses a blood condition that can affect the kidneys. There are no new results to report.
Apheresis treatment approaches for ANCA-associated vasculitis in children synthesis of clinical data and case-based expert strategies
This is a preprint about a blood-cleaning treatment for a rare blood vessel disease in children. It is not yet peer reviewed. There are no results to report yet.
Cardiovascular Classification in Middle‐Aged and Elderly CKD Patients: A Machine Learning Approach in China and the United States
This study used computer programs to predict heart disease in people with kidney disease. It looked at data from the US and China. The computer models helped sort who was at risk....
Diabetes medication use in the last year of life in people living with dementia in the United Kingdom and Australia
This study looked at people with dementia who also had diabetes. It checked if they stopped taking their diabetes pills near the end of life. The study found that some people did...
Older Patients and Conservative Kidney Management.
This study looked at why older adults choose to skip dialysis. It found that family members often play a big role in this decision. The study shows a link between family support...