← brief for 2026-09-28 · Slowing decline
Anp32e mediates histone variant H2A.Z-regulated TGF-β1 involvement in renal interstitial fibrosis.
Key takeaways
This study looked at kidney cells in a lab model of scarring. It found that a protein called Anp32e plays a role in how the cells respond to a signal that causes scarring. This research was done in cells, not in people yet. It helps explain the basic biology of kidney damage, but it is not a test of a treatment in humans.
Who did this work
Zeng D (Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China; Key Laboratory of Kidney Disease and Blood Purification in Hunan Province, Changsha, 410011, Hunan, China.) · Tang C (Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China; Key Laboratory of Kidney Disease and Blood Purification in Hunan Province, Changsha, 410011, Hunan, China.) · Shan Y (Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China; Key Laboratory of Kidney Disease and Blood Purification in Hunan Province, Changsha, 410011, Hunan, China.) · Wei J (Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China; Key Laboratory of Kidney Disease and Blood Purification in Hunan Province, Changsha, 410011, Hunan, China.) · Liu Q (Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China; Key Laboratory of Kidney Disease and Blood Purification in Hunan Province, Changsha, 410011, Hunan, China.) · Yin X (Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China; Key Laboratory of Kidney Disease and Blood Purification in Hunan Province, Changsha, 410011, Hunan, China. Electronic address: [email protected].) · Li Y (Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China; Key Laboratory of Kidney Disease and Blood Purification in Hunan Province, Changsha, 410011, Hunan, China. Electronic address: [email protected].)
Source
Article · Europe PMC, CKD · 2026-09-23
https://doi.org/10.1016/j.bbadis.2026.168467