← brief for 2026-09-28 · Regeneration & devices

Polymyxin B Attenuates Sepsis-Induced Acute Kidney Injury by Activating a SUMO1-p65 "Molecular Brake" in Kidney Organoids.

Article D Peer reviewed Preclinical

Key takeaways

This study used mouse kidney organoids and mice to test a drug called polymyxin B. It found the drug reduced inflammation in the kidney models. It was done in animals and cells, not people yet. It shows a possible mechanism for how the drug works.

Who did this work

Wang Q · Xue N · Yu T · Li Y · Bian X · Hou X · Dou L · Feng Q · Liu X

Source

Article · PubMed, organoids & devices · 2026 Oct
https://pubmed.ncbi.nlm.nih.gov/42803384/