Kidney research, 2026-09-23
Strong evidence shows diabetes drugs protect kidneys in type 2 diabetes.
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Researchers are testing a new urine light test for lupus kidney disease, but it is not yet a standard tool.
The main news today is strong support for using common diabetes medications to protect kidneys. This evidence comes from a very large group of patients. Other items are smaller studies or early tests that need more proof before they change standard care.
The osteogenic regulator THOC5-dependent post-transcriptional control maintains vascular smooth muscle cell homeostasis against chronic kidney disease related vascular calcification
This study used cells in a lab, not people. It found a protein called THOC5. This protein helps stop blood vessels from hardening. Hardening is a common problem in kidney disease....
Recommendations for the Management of Anemia in Patients with Cancer and Chronic Kidney Disease: A Position Statement from the American Society of Onco-Nephrology (ASON)
This is a set of guidelines for doctors. It covers how to treat low blood cell counts in people with both cancer and kidney disease. It is a position statement, so it does not...
Potential Diagnostic and Therapeutic Role of Amino Acids in Diabetic Kidney Disease: An Updated Review.
This review looks at how amino acids, which are building blocks of protein, might help people with diabetic kidney disease. It summarizes existing research but does not report new...
Phase 1a Study Assessing Safety, Tolerability, Pharmacokinetics, and Immunogenicity of PMG1016
This is a first-in-human trial for a new drug called PMG1016. It will test the drug in healthy adults to check for safety. There are no results yet as the trial is in its early...
Association of Chronic Vascular Complications of Diabetes With Cardiovascular Autonomic Neuropathy: The Silesia Diabetes-Heart Project.
This study looked at 728 adults with diabetes to see if nerve damage in the heart links to other diabetes complications. It found a link between heart nerve issues and other blood...
The Gut–Kidney Axis in Chronic Kidney Disease: Microbial Dysbiosis, Host–Microbial Metabolism, and Emerging Therapeutic Strategies
This article reviews how gut bacteria might affect kidney health. It discusses how changes in gut microbes may link to kidney damage. It is a summary of past research, not a new...
What is the effect of GLP-1s on eGFR?
This is a short note on how GLP-1 drugs affect kidney function. It says these drugs may help protect kidneys in people with diabetes. It is not a full study, so there are no...
A Comparison of the 2009 CKD-EPI and EKFC Equations for Estimating GFR in a Large Italian Outpatient Cohort, and the Potential Consequences for Patients’ Management
This study compared two math formulas used to estimate kidney function. It looked at a large group of patients in Italy. It found that the newer formula may be more accurate for...
Incidence, Risk Factors, and Renal Outcomes of Cancer Patients Treated With Immune Checkpoint Inhibitor: A Retrospective Cohort Study in a Single Tertiary Hospital in the Philippines
This study looked at cancer patients taking a specific type of drug. It found that some of these drugs can hurt the kidneys. It shows a link between the drug and kidney injury, but...
Flow Cytometry and AI-Driven Biomarker Discovery in Acute Kidney Injury: From Mechanistic Insights to Translation Applications in Clinical and Austere Environments
This article reviews how scientists use flow cytometry and AI to find markers for acute kidney injury. It explains the biology behind sudden kidney damage. There are no new patient...
Pathogenesis of Calcium Oxalate Kidney Stones, Interactions Among Mitochondria, NADPH Oxidase and Endoplasmic Reticulum
This review explains how calcium oxalate stones form and damage kidney cells. It looks at how cell parts like mitochondria react to stress. It does not report a new trial or...
Beyond the Heart‐Lung Axis: A Review of the Crosstalk Between the Hemodynamic, Neurohormonal, and Immune Systems in Pulmonary Hypertension
This review covers how the heart, lungs, and immune system talk to each other in pulmonary hypertension. It summarizes known biology but does not report new patient trial results.
Results from the Phase 2 Explore-CKD Trial of lorundrostat, a novel aldosterone synthase inhibitor, in participants with uncontrolled hypertension, chronic kidney disease, and albuminuria
A new drug called lorundrostat was tested in people with kidney disease and high blood pressure. The drug lowered blood pressure and was safe. This is a Phase 2 trial, which is a...
Citrate-Dependent Activation of Acetyl CoA Carboxylase Promotes Renal Lipid Accumulation in a Rat Model of Chronic Kidney Disease.
This study used rats and cells, not people. It found that a chemical called citrate can cause fat to build up in the kidney. This may help explain how kidney disease gets worse. It...
New pharmacologic and interventional horizons in hypertension and nondialysis chronic kidney disease: bridging innovation and clinical translation.
This is a review of new blood pressure drugs for people with kidney disease. It talks about what is coming, but it does not report new trial results. It is a discussion, not a...
Long-Term Renal Function and Clinical Outcomes of Sacubitril/Valsartan in HFrEF and Stage 3-4 Chronic Kidney Disease: A 24-Month Single-Centre Cohort.
This study followed 360 people with heart failure and kidney disease for up to 24 months. It found that a drug called sacubitril/valsartan was safe and did not make kidney function...
Twenty-Four-Week UACR Response Trajectories and Clinical Correlates of Residual Albuminuria in Diabetic Kidney Disease During Finerenone Therapy: A Real-World Longitudinal Study.
This study looked at 136 people with diabetic kidney disease taking a drug called finerenone. It found that some people still had protein in their urine after 24 weeks. This is an...
SGLT2 inhibitors and outcomes in the chronic Post-LVAD phase: a multicenter real-world cohort study.
This study looked at people with heart machines called LVADs. It found that a type of diabetes drug called SGLT2 inhibitors was linked to better outcomes. This is an observational...
Non-albumin proteinuria as a candidate biomarker of treatment response to finerenone in diabetic kidney disease: a real-world cohort study.
This study looked at 477 people with diabetic kidney disease taking finerenone. It found that a type of protein in the urine may show how well the drug is working. This is an...
Postoperative Acute Kidney Injury in Cardiovascular Surgery Patients with Prolonged Intensive Care Unit Stay: Impact on Mortality and Outcomes.
This study looked at people who had heart surgery and stayed in the ICU for at least 72 hours. It found that those who developed sudden kidney damage had higher rates of death in...
Prevalence of Undertreated CKD among Hospital Inpatients: A Prospective Cross-Sectional Study.
This study checked how many hospital patients had kidney disease that was not being treated. It found that many people with stage 3b to 5 kidney disease were missed by doctors....
Undiagnosed Chronic Kidney Disease, Outcomes, and Finerenone in Heart Failure: The FINEARTS-HF Randomized Clinical Trial.
This analysis looked at a large trial of a drug called finerenone. It studied people with heart failure who also had kidney disease. The study found that many of these patients had...
Comparative Effectiveness of Once-Weekly Semaglutide Versus Sulfonylureas, DPP4 Inhibitors, and Thiazolidinediones in Patients with Type 2 Diabetes and Chronic Kidney Disease.
This study compared a weekly diabetes shot called semaglutide with older pill-based drugs. It looked at real-world data from people with type 2 diabetes and kidney disease. The...
Longitudinal serum uric acid trajectories and chronic kidney disease progression.
This study tracked uric acid levels in people with kidney disease over time. It found that rising uric acid levels were linked to faster kidney decline. This shows a connection,...
Renal outcomes in people with type 2 diabetes with and without albuminuria treated with SGLT-2 inhibitors and GLP-1 receptor agonists: target trial emulation.
This large study used data from many health systems to compare two diabetes drugs. It looked at people with type 2 diabetes and kidney function above a certain level. The study...
GLP-1 receptor agonists and podocyte senescence in diabetic kidney disease: structural pharmacology, mechanistic evidence, and multi-receptor agonism.
This review explains how certain diabetes drugs affect kidney cells. It focuses on a process called cell aging, or senescence. The study looks at how the drugs bind to these cells...
A lightweight dual-representation cross-attention framework for urinary FTIR classification of lupus nephritis and subtype discrimination.
This study developed a new way to use urine tests to check for lupus kidney disease. It uses a type of light spectrum analysis to look at urine samples. This shows a link between...
Bu Shen Huo Xue Formula ameliorates chronic kidney disease and suppresses NLRP3 inflammasome-mediated pyroptosis and renal fibrosis.
This study tested a traditional Chinese medicine formula in mice. The mice had kidney damage caused by a specific injury. The formula helped reduce scarring and inflammation in the...
Feasibility and Clinical Consequences of Liberal Fasting Compared to Standard Practice Prior to Elective Coronary Angiography: Results from a Randomized Trial.
This trial compared strict fasting with a more relaxed eating plan before a heart test. It looked at whether skipping food caused problems like low blood sugar. The study found...
Impact of Mindfulness on Pain In SA
This is a trial registration for a study in Saudi Arabia. It plans to test if a five-week meditation program helps dialysis patients with pain. The study is not yet complete, so...
Deletion of protein FSTL3 unravels the role of activin signaling in regulating macrophage L-arginine metabolism and kidney injury
This study looked at a protein called FSTL3 in the lab. It found that this protein helps control how immune cells handle a chemical called L-arginine. This process is key to...
Novel human neutralizing monoclonal antibodies against Pregnancy-Associated Plasma Protein A for the treatment of Autosomal Dominant Polycystic Kidney Disease
Researchers tested a new drug in mice with polycystic kidney disease. The drug blocks a protein that makes cysts grow. In the mice, the drug helped slow the disease. This was done...
Safety and Feasibility of a Novel Percutaneous Locoregional Injection Technique of Renal Cellular Therapy for Chronic Kidney Disease of Diabetes
This is a record of a study on injecting cells into the kidney. It is a planned or early-stage study. There are no results yet to report.
Balancing Benefits and Risks: A Systematic Review and Meta-Analysis of ABO-Incompatible Kidney Transplantation.
This review looked at many studies to compare kidney transplants from donors with different blood types against standard matches. It found that both groups had similar survival...
Bilateral renal vascular multiplicity precluding kidney donation
This is a report about one man who wanted to donate a kidney. He had a rare blood vessel shape that made donation too risky. It is a single case, not a study with results.
ISN leads the discussion on kidney health action and sustainable health systems for NCDs at UNGA81 - International Society of Nephrology
A major kidney health group held a meeting at the United Nations. Leaders talked about how to make health systems stronger. They want to handle chronic diseases like kidney failure...
CommunityRx-Kidney Health
This is a planned study to help people in rural areas manage kidney disease. It uses technology to connect patients with care resources. There are no results yet because the study...
Determinants of Televisits in Diabetology in the Tuscany Region
This study looked at records from Tuscany to see who uses video visits for diabetes care. It found that certain patient groups are more likely to use telehealth. This shows a link...
Stool from a Dormant Peritoneal Dialysis Catheter
This is a report about one man who had a rare problem with his dialysis tube. It is a single case, not a study with results.
Kidney Advocacy Starts at Home: KAC Meets With Local Congress Members
This is a news article about kidney advocates meeting with local lawmakers. It discusses policy priorities but reports no research results.