Kidney research, 2026-09-07
Fatty liver disease is linked to higher chances of kidney problems and other health issues
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Lab and animal studies suggest fat buildup in the liver may harm kidney tube cells, but this has not been confirmed in people.
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Dialysis water safety remains important, as unsafe water can lead to serious infections or other complications.
Today's findings focus on how fatty liver disease connects to other health problems, including kidney disease. One large snapshot study showed a link between fatty liver and chronic kidney disease, though it cannot prove cause and effect. Lab research hints at how fat might damage kidney cells, but human data is still needed. Dialysis water safety was also highlighted as a practical concern for patients on treatment.
Beyond Genotype: Proteomic Risk Stratification for APOL1-Mediated Kidney Disease
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Cumulative Vascular Burden: The Prognostic Value of a Time-Weighted Cardio-Ankle Vascular Index in Haemodialysis Patients.
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Early Mortality in Incident Hemodialysis Patients: Risk Factors and Nomogram Prediction.
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Urinary Sclerostin and Renal Magnesium Handling in Proteinuric Non-Diabetic Chronic Kidney Disease.
Sclerostin is a protein involved in the bone and mineral problems that come with kidney disease. Researchers measured it in the blood and urine of 70 adults who had kidney disease...
uPAR Amplifies Macrophage Inflammation via NF-κB Pathway to Promote Fibrotic Transition Following Acute Kidney Injury.
After a sudden kidney injury, ongoing inflammation can push the kidney into long-term disease with permanent scarring. In mice with a blocked and then restored blood supply to one...
Clinical Severity of Diabetic Ketoacidosis by SGLT2 Inhibitors Use: A Retrospective Observational Study.
SGLT2 inhibitors are diabetes drugs that also protect the kidneys and heart. A rare side effect is diabetic ketoacidosis, a dangerous build-up of acid in the blood. Researchers...
Serum Cystatin C Predicts Postsurgical Acute Kidney Injury in Aortic Dissection
Cystatin C is a blood marker of how well the kidneys filter waste. This study checked whether the level measured around surgery predicted sudden kidney injury after an operation...
Effect of Tenofovir on Renal Function among Bangladeshi Adults on Long-term Antiretroviral Therapy: A Cross-sectional Study
Doctors measured kidney function in adults in Bangladesh who had taken tenofovir, an HIV drug, for a long time. Everyone was tested at a single point in time, with no...
ASSOCIATION OF SERUM HEPARAN SULFATE AND SYNDECAN-1 LEVELS WITH ECHOCARDIOGRAPHIC PARAMETERS IN PATIENTS WITH CHRONIC HEART FAILURE STRATIFIED BY GLOMERULAR FILTRATION RATE
Heparan sulfate and syndecan-1 are pieces of the thin protective lining inside blood vessels. This study measured them in the blood of people with long term heart failure, then...
PREDICTION OF CHRONIC KIDNEY DISEASE DEVELOPMENT IN PATIENTS WITH PODOCYTIC DYSFUNCTION IN POST-COVID SYNDROME
Podocytes are the cells that form the kidney's filter. This study looked at people with lasting symptoms after COVID whose podocytes were not working properly, and asked who went...
Risk factors for gastrointestinal bleeding in patients with chronic kidney disease
Bleeding in the stomach or gut is a known danger for people with chronic kidney disease. This study looked back at patient records to find which factors go along with that...
An Acidic Tubulointerstitial Microenvironment Delays Cell-Cycle Progression in Proximal Tubule Cells and Fibroblasts and Synergizes With Lactate to Drive Phenotypic Alterations.
Researchers grew human kidney filter-tube cells and scar-forming cells in acid, the condition seen inside damaged kidneys. The acid slowed the cells' growth cycle, and adding...
Lactate-Mediated Lysine Lactylation in Renal Fibrosis: Current Progress and Challenges.
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GLP-1 receptor agonists beyond glycemic control: integrated cardio-renal-metabolic protection across the cardiovascular kidney metabolic continuum.
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Clinical Significance of Increased Degree of Hematuria in Patients affected by IgA Nephropathy.
Doctors looked back at records from 696 people with IgA nephropathy, a disease in which the immune system damages the kidney's filters. Everyone in the group had lasting blood in...
Association between phase angle and albuminuria in Korean adults aged 40 years or older: a cross-sectional study of the 9th Korea National Health and Nutrition Examination Survey (2022-2023).
This study used Korea's national health survey from 2022 and 2023 to check adults aged 40 and older. It compared phase angle, a body reading taken with a small electrical current...
An integrative review of APOL1 kidney disease with a focus on the Brazilian population.
This paper gathers earlier studies about APOL1, a gene that comes in versions linked to a higher risk of kidney disease. It looks at what those studies mean for people in Brazil,...
[Across-sectional study on the association between steatotic liver disease and its subtypes, cardiovascular health status, and extrahepatic comorbidity].
This study looked at people with fatty liver disease, meaning extra fat stored in the liver, and counted how many also had chronic kidney disease, type 2 diabetes, high blood...
Impact of renal lipid droplet dynamics on tubular health.
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Uric Acid and Cardiovascular Disease.
This is a review article about high uric acid in the blood, the waste product that causes gout. The authors describe how it is tied to heart disease, diabetes, and chronic kidney...
Protective and Antioxidant Effects of Moringa oleifera Extract Against Cisplatin-Induced Renal Injury in Male Rabbits
Researchers gave male rabbits an extract of the moringa plant, then gave them cisplatin, a chemotherapy drug known to damage kidneys. The extract appeared to protect the kidneys...
Clinical Outcomes of Patients Ineligible for Arteriovenous Vascular Access: A Retrospective Cohort Analysis
Some people on dialysis cannot have the usual permanent access made in the arm, where an artery and a vein are joined so blood can be cleaned. This study looked back at hospital...
Machine learning for early detection of chronic kidney disease
Researchers trained a computer program to spot chronic kidney disease early from routine health data. The program was tested on records that already existed, not on patients in a...
D4F-Functionalized Ceria Nanozyme-CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury.
Scientists built a tiny fat-coated particle carrying two things: a cerium-based agent that mops up damaging molecules, and a gene-blocking tool aimed at STING, an alarm switch in...
Proteomic profiling of cephalic vein reveals potential biomarkers for arteriovenous fistula neointimal hyperplasia in ESRD patients.
A fistula is a surgical join between an artery and a vein in the arm, used to connect people to a dialysis machine. It often fails because the vessel wall thickens on the inside....
Combined FMEA and Cause-Effect Analysis Method for Risk Assessment of Failures Impacting Hemodialysis Water Quality.
People on hemodialysis have their blood cleaned with large amounts of water every week, so bad water can harm them. Researchers used two formal safety checklists to rank what can...
Immune reactivity and tacrolimus variability in kidney transplantation
After a kidney transplant, people take tacrolimus so the body does not attack the new kidney. This study looked at whether swings in the drug level in the blood go along with a...
Mandatory Payment Reform and the Geography of Dialysis Supply: Experimental Evidence from Medicare's End-Stage Renal Disease Treatment Choices Model
Medicare assigned new payment rules for kidney failure care to some regions by lottery, under a program called the ESRD Treatment Choices model. This paper asks whether those...
Chronic kidney disease due to hypertension in China, Japan, and the Republic of Korea: trends from the Global Burden of Disease Study 1990–2023
This counts how much kidney disease caused by high blood pressure there was in China, Japan and South Korea from 1990 to 2023. It uses the Global Burden of Disease database, which...
Dialysis deserts in the Philippines: a national geospatial modeling study of dialysis services.
Researchers mapped dialysis centers across the Philippines and measured how far people with kidney failure have to travel to reach one. Centers cluster in cities, so people in...
Kidney research at an inflection point: why the next decade must be different
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