← brief for 2026-09-07 · Slowing decline

uPAR Amplifies Macrophage Inflammation via NF-κB Pathway to Promote Fibrotic Transition Following Acute Kidney Injury.

Key takeaways

After a sudden kidney injury, ongoing inflammation can push the kidney into long-term disease with permanent scarring. In mice with a blocked and then restored blood supply to one kidney, a protein called uPAR switched on during the injury and ramped up inflammation in immune cells. This points to uPAR as a possible target for stopping that slide into chronic disease. It was done in animals, not people, so there is no evidence yet that blocking it helps patients.

Who did this work

Zheng S · Chen Y · Liu J · Gong N · Fu Y · Zhang Z · Long L · Wang Y · Chen X · Hong Q · Sun X

Source

Article · PubMed, CKD progression and prevention · 2026 Sep 7
https://pubmed.ncbi.nlm.nih.gov/42704671/