Kidney research, 2026-10-23
New reviews show diabetes drugs may protect your heart and kidneys.
Today's news focuses on how common diabetes medications might offer extra protection for your heart and kidneys. The strongest evidence comes from large reviews of SGLT2 inhibitors and GLP-1 drugs. These findings suggest that managing blood sugar may also help lower the risk of serious heart problems. While these are promising results, they are based on reviews of existing data rather than new single trials.
Long-Term Opioid and Gabapentinoid Related Harms in CKD.
This large study followed nearly one million people with kidney disease. It looked at long-term use of strong pain medicines. It found a link between these drugs and higher risks...
Polysocial risk score predicts chronic kidney disease incidence and prognosis: mechanistic insights from plasma metabolome, proteome and lifestyle.
This study looked at 279,548 people who did not have kidney disease at the start. It also followed 19,761 people who already had the condition. The researchers used a score based...
Bilateral Staghorn Calculi With Stent Encrustation in a Patient With an Ileal Conduit Requiring Staged Endourological Procedures: A Case Report.
This report describes one patient with kidney disease and a urinary diversion. He had large kidney stones that required a complex, staged surgery. The article details the specific...
Trends in Mortality of Patients with Central Venous Catheters versus Arteriovenous Accesses for Hemodialysis.
This study compared two ways to connect to dialysis. It looked at people who started with a catheter versus an artery-vein connection. It checked if death rates changed over time....
Plasma Proteomics of Cancer Risk Among Patients with CKD.
This study looked at blood proteins in people with chronic kidney disease. It tried to find markers for cancer risk. It used a large group of patients. This shows a link, not proof...
2026 International Society of Hypertension Global Hypertension Practice Guidelines.
This is a set of new rules for treating high blood pressure. It is written by a global group of experts. It gives advice on how to manage blood pressure. This is a guideline, not a...
Lessons from dog lifespan therapeutics for their human companions.
This article discusses how drugs for dogs might help humans live longer. It looks at drugs that protect the heart and kidneys. It talks about how to get these drugs approved for...
Association of GLP-1 Receptor Agonist Use with Thyroid Outcomes in Adults with Type 2 Diabetes.
This study looked at records of people with type 2 diabetes. It compared those who started a GLP-1 drug to those who started a different diabetes drug. It checked for thyroid...
The Veterans Affairs Pentoxifylline in Diabetic Kidney Disease (VA PTXRx) Study: Baseline Characteristics.
This paper describes the start of a new trial. It tests a drug called pentoxifylline in people with diabetic kidney disease. The goal is to see if it slows kidney failure. This is...
Modern antidiabetic therapy in older adults with type 2 diabetes: evidence, best practice and a clinical pharmacist's framework.
This is a review of how to treat diabetes in older adults. It looks at drugs that protect the heart and kidneys. It also covers the risks of low blood sugar. This is a summary of...
Herbal-Cake-Separated Moxibustion Ameliorates Renal Fibrosis and Associated Bone Injury in Rats via the TGF-尾1/Smad Signaling Pathway.
This study looked at a traditional heat therapy in rats with kidney disease. The rats had kidney scarring and bone problems. The therapy was tested in a very small group of 6 rats...
Construction Trade Work Is Associated With Accelerated Decline in Kidney Function.
This study followed 9,192 construction workers. It found that exposure to dust and fumes on the job is linked to faster kidney decline. It shows a link, but it is not proof that...
Routine antinuclear antibody testing as an independent prognostic biomarker for end-stage renal disease in ANCA-associated vasculitis: a longitudinal cohort study.
This study looked at 236 patients with a specific type of blood vessel inflammation. It found that a certain antibody test is linked to a higher risk of kidney failure. It shows a...
Preoperative CT-derived renal tumor burden and postoperative renal function after partial nephrectomy: an exploratory analysis of KiTS23
Researchers used CT scans to measure the size of kidney tumors before surgery. They found that a higher tumor burden was linked to lower kidney function after the operation. This...
Reduced Risk of MASLD and Cardiometabolic Disease Following Renal Denervation Therapy in Patients With Resistant Hypertension
A study of patients with hard-to-control high blood pressure found that a procedure called renal denervation was linked to a lower risk of liver and metabolic disease. This is an...
Real鈥怲ime Continuous Glucose Monitoring Use and Kidney Function Among People With Diabetes and CKD or At鈥怰isk for CKD
A study of people with diabetes and kidney disease found that using a continuous glucose monitor was linked to better kidney function over three years. This is an observational...
Characterization of IgA, IgA immune complexes and complement depositions in IgA nephropathy using laser microdissection and mass spectrometry
This item is a journal page describing a method to study kidney tissue. It explains how immune proteins build up in a specific kidney disease. There are no new patient results or...
Association of Finerenone Dose and Estimated Glomerular Filtration Rate (eGFR) Slope Changes in Patients With Diabetic Kidney Disease: A Real-World Retrospective Study.
This study looked at 104 people with diabetic kidney disease who took a drug called finerenone. It checked if the dose changed how fast their kidney function declined. This is an...
Finerenone-Empagliflozin Combination Therapy in Apparent Resistant Hypertension: A CONFIDENCE Trial Post Hoc Analysis.
This analysis looked at a trial of two drugs, finerenone and empagliflozin. The trial focused on people with kidney disease and type 2 diabetes. It checked if the drugs helped...
SGLT2 inhibitor therapy following aortic valve intervention for aortic stenosis: a systematic review and meta-analysis of mortality, heart failure, rhythm, renal, and valve-related outcomes.
This review combined data from many studies on heart valve surgery. It looked at a diabetes drug called SGLT2 inhibitors. The review found that these drugs were linked to lower...
GLP-1-based therapies in cardiovascular disease: outcomes, mechanisms, and emerging clinical applications.
This review looked at GLP-1 drugs, which are often used for diabetes. It found that these drugs lower the risk of major heart events. The risk dropped by 12% to 26% in people with...
Sodium-glucose cotransporter-2 inhibitors and mortality and liver-related outcomes in patients with alcoholic cirrhosis, type 2 diabetes, and obesity.
This study looked at people with severe liver scarring, type 2 diabetes, and obesity. It compared those taking a diabetes drug called an SGLT2 inhibitor to those who were not. The...
METTL14 Declines Th17/Treg Ratio Via the m6A Modification of DUSP23 to Alleviate Systemic Lupus Erythematosus.
This study looked at a protein called METTL14 in cells and mice. It found that this protein helps balance the immune system. It may help with lupus, an autoimmune disease. This was...
Association of the serum uric acid/albumin ratio with kidney composite events in patients with type 2 diabetes mellitus: a retrospective cohort study.
This study looked at 3,618 people with type 2 diabetes. It checked a blood test called the uric acid to albumin ratio. It found a link between a higher ratio and kidney problems....
Predictors of physical performance decline in patients receiving maintenance hemodialysis: a prospective observational study.
This study followed people on dialysis to see what leads to physical decline. It found that low bone density and weak muscles are strong signs of getting weaker. This shows a link,...
Irisin fails to rescue bone loss in a rat model of chronic kidney disease - mineral bone disorder (CKD-MBD) but interacts with parathyroid hormone (PTH) in vivo and in vitro in IDG-SW3 osteocytes.
This study tested a protein called irisin in rats with kidney disease. It found that irisin did not stop bone loss in the animals. This was done in rats and cells, not in people...
Low Daily Protein Intake and Risk of Kidney Failure and Mortality in Chronic Kidney Disease
A large study of Korean patients with kidney disease found that eating less protein was linked to a lower risk of kidney failure. This is an observational study, so it shows a...
Collaborative role of muscle ultrasonography and subjective global-nutritional assessment in pediatric end-stage renal disease
Researchers looked at how to best measure nutrition in children on dialysis. They found that using muscle ultrasound along with a standard nutrition check gave a clearer picture of...
Studi Kasus Asuhan Gizi Terstandar Pada Pasien Chronic Kidney Diasease (CKD) Dengan Hipertensi di RSUD Toto Kabila Bone Bolango
This report describes the care of one man with late-stage kidney disease and high blood pressure. It details how a nutrition team created a meal plan for him during a four-day...
The Obesity Paradox in Chronic Kidney Disease: Cardiorespiratory Fitness Is Associated With Mortality Independent of Body Mass Index.
A large study of 13,521 veterans with kidney disease found that being fit was linked to lower risk of death. This held true even for people who were overweight. This is an...
Acetochlor Induces Nephrotoxicity in Chicken through IP3R1-GRP75-VDAC1-Mediated Stabilization of Mitochondria-Associated MAMs and the Regulation of Apoptosis and Autophagy, an Effect That Is Mitigated by Omega-3 Fatty Acids.
This study looked at a pesticide called acetochlor in chickens. It found that the pesticide caused kidney damage. Omega-3 fatty acids helped reduce this damage. This was done in...
Impact of nurse-led intervention on the level of anxiety and depression among chronic kidney disease patients at Bhubaneswar, Odisha, India.
This study looked at how nurse-led care affects anxiety and depression in kidney disease patients. It used a randomized design to compare groups. The study did not report the exact...
Impact of hypothermia level on neurological and renal outcomes in emergency aortic surgery: a single-centre experience.
This study looked at how cold the body gets during emergency heart surgery. It checked if this affects the brain and kidneys. The data came from one hospital over five years. It...
Characterization of human induced pluripotent stem cell (hiPSC)- derived Kidney Organoids as a Platform to Assess Drug-Induced Nephrotoxicity.
Researchers created tiny 3D kidney models from human stem cells. These models are called organoids. They are used to test if new drugs might harm the kidney. This work was done in...
Sensory neuron-derived CGRP ameliorates kidney injury and fibrosis via monocytes and macrophages
This study looked at how pain-sensing nerves in the kidney help protect the organ. It found that these nerves release a chemical that calms down immune cells. This action helps...
Early Transplant Outcomes and Kidney Donor Profile Index Risk Prediction Performance in Kidneys Recovered Using a Uniform Abdominal Normothermic Regional Perfusion Technique.
This paper tested a new way to recover kidneys from donors. It compared this method to a faster recovery style. The study looked at 523 transplants over two years. It shows a link...
Incidence of Biopsy-Proven Paediatric Glomerular Disease in Southeast England: A Retrospective Cohort Study
This is a preprint of a study looking at kidney disease in children in England. It has not been checked by other experts yet. There are no final results to report at this time.
A clinical case of the apoplexy of pelvicalyceal system of the left kidney caused by compression of the ureter by lymphocele
This article describes one rare case of a kidney injury. It is a single patient story, not a large study. It does not provide general results for all people with kidney disease.
In-hospital outcomes by peritoneal versus hemodialysis inpatient procedure coding in adults with end-stage kidney disease: a 2021 National Inpatient sample study
This study looked at 152,055 people with end-stage kidney disease who were in the hospital. It compared those on peritoneal dialysis with those on hemodialysis. The group on...
Experiences of self-advocacy in patients with chronic kidney disease: a qualitative study
This is a published study about how patients speak up for their care. The record does not include an abstract with specific findings. There are no detailed results to summarize...
Deteksi Dini Penyakit Gagal Ginjal sebagai Komplikasi Hipertensi melalui Edukasi Masyarakat di Desa Sokaraja Kulon, Sokaraja, Banyumas, Jawa Tengah
This was a community program to teach people about high blood pressure and kidney health. It involved health checks and education in a village. It is a report on a service project,...
Quantitative coronary plaque characteristics on coronary computed tomography angiography and their prognostic value in patients with chronic kidney disease
This is a published study on heart scans for people with kidney disease. The record does not include an abstract with specific findings. There are no detailed results to summarize...
Video Decision Support and Advance Care Planning in Older Adults With Advanced Kidney Disease
A trial of 12 clinics found that watching a video about dialysis options helped older adults plan their care better. The study was small, and the effect was measured over 12...