← brief for 2026-10-23 · Nutrition & lifestyle

Irisin fails to rescue bone loss in a rat model of chronic kidney disease - mineral bone disorder (CKD-MBD) but interacts with parathyroid hormone (PTH) in vivo and in vitro in IDG-SW3 osteocytes.

Article D Peer reviewed Preclinical

Key takeaways

This study tested a protein called irisin in rats with kidney disease. It found that irisin did not stop bone loss in the animals. This was done in rats and cells, not in people yet.

Who did this work

Wilson HE · Chen NX · O'Neill KD · Metzger CE · Srinivasan S · Stephen DJ · Blacklock K · Matter EK · Bonewald LF · Allen MR · Moe SM

Source

Article · PubMed, Lifestyle and CKD · 2026 Oct 5
https://pubmed.ncbi.nlm.nih.gov/42908875/