Kidney research, 2026-10-21
Today’s kidney research digest
A new review found that high-intensity interval training is the best type of exercise for lowering blood fats. Other studies looked at kidney transplant care, bone loss, and a rare case of kidney damage from leukemia.
Trace element supplementation preserves metabolic resilience in chronic kidney disease
This preprint reports a trial of 80 people on dialysis. Half took a mix of trace elements, and the other half took a placebo. The group taking the elements showed better metabolic...
Beyond Kidney Volume: 3D Mapping of Parenchymal, Cortical and Medullary Thickness with Disease, Anthropometry and Kidney Adiposity
This preprint used scans from 70,270 people to map the inside of their kidneys. It found that the thickness of kidney tissue is linked to disease and body fat. This is an...
Nationwide outcomes of biliary atresia after Kasai portoenterostomy in Taiwan: the impact of postoperative cholangitis and corticosteroid use.
This study looked at 334 infants with a liver condition called biliary atresia. It is a retrospective review, so it shows a link, not proof of cause. The study found that many...
Initiation of Apixaban Versus Warfarin in Patients With Kidney Failure on Hemodialysis With Newly Diagnosed Atrial Fibrillation: A Target Trial Emulation
This study compared two blood thinners, apixaban and warfarin, in people on dialysis with an irregular heartbeat. It used a method that mimics a randomized trial to see which drug...
Patient Perspective on the KDOQI Commentary on the 2025 AHA/ACC Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults
This is a letter from patients with kidney disease about new blood pressure guidelines. It discusses how managing blood pressure protects kidney function. It is an opinion piece,...
KDOQI Commentary on the 2025 AHA/ACC Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults
This is a commentary on a new blood pressure guideline. The guideline now includes kidney health in its risk tools. It is a review of the rules, not a study with new results.
Continuous Glucose Monitoring in Patients With Diabetes on Peritoneal Dialysis
This study is planned to test if continuous glucose monitors help people with diabetes on peritoneal dialysis. It aims to improve blood sugar control, which is hard to manage...
Finerenone versus Steroidal MRAs in Type 2 Diabetes and Chronic Kidney Disease without Prior Heart Failure.
This study compared two types of blood pressure drugs in people with diabetes and kidney disease. It used records from many hospitals. It shows a link between drug choice and...
Sucrose induces Cardiac Hypertrophy and Renal Perivascular Fibrosis in a Novel Mouse Model of Hypertension
Mice that drank sugary water developed high blood pressure and kidney scarring. This was a lab study in animals, not people yet. It shows how sugar may affect the heart and...
Landscape Fire-Sourced PM2.5 and Cause-Specific Renal Hospitalizations: A Multicountry Two-Stage Time-Series Analysis of 12.5 Million Admissions
A large review of 12.5 million hospital visits found that wildfire smoke was linked to more kidney emergencies. This was an observational study, so it shows a link, not proof of...
Colchicine Initiation and Kidney Outcomes in Adults With Chronic Kidney Disease: A Target Trial Emulation With a Nested Inflammatory Biomarker Analysis
This is a plan for a study on whether the gout drug colchicine affects kidney health. It will look at how the drug impacts kidney decline and heart outcomes. There are no results...
Arterial Hypertension and Kidney Function Decline in Systemic Sclerosis and Sjögren’s Disease: A Longitudinal Comparative Study
This study looked at people with two specific autoimmune diseases. It tracked how their kidney function changed over up to 3 years. The researchers wanted to see if high blood...
Association of the C-reactive protein-to-HDL cholesterol ratio with all-cause mortality in Chinese adults with impaired renal function: a prospective cohort study
A study of 2,202 people with kidney disease found a link between a blood test marker and death. The marker is the ratio of C-reactive protein to HDL cholesterol. Higher levels of...
Association between ambient temperature and acute kidney injury: a nationwide space-time-stratified case-crossover study in Japan
This study looks at how outside temperature affects sudden kidney injury in Japan. It is a nationwide study, but the record does not include the results. There are no findings to...
Direct Oral Anticoagulants in the Cardiorenal Patient: Pharmacology, Kidney Function Estimation and Dose Selection Across the CKD Spectrum
This review explains how to pick the right dose of blood thinners for people with both heart and kidney disease. It looks at how kidney function changes affect drug safety. The...
Targeting Inflammatory, Fibrotic, Hemodynamic, and Metabolic Pathways in Chronic Kidney Disease: Emerging Pharmacotherapies and Precision Treatment Strategies
This review covers new drug strategies for chronic kidney disease. It looks at how to target inflammation, scarring, and blood flow. It is a summary of current research, not a new...
ECHOCARDIOGRAPHY-GUIDED HAEMODYNAMIC MANAGEMENT AND CARDIORENAL INTERACTION IN YOUNG CHILDREN AFTER SURGICAL REPAIR OF CONGENITAL HEART DEFECTS
This item discusses using heart scans to manage kidney issues in children after heart surgery. It explains how to adjust fluids and drugs based on heart function. It is a clinical...
Association between insulin resistance surrogate indices and incident chronic kidney disease among the population with cardiovascular-kidney-metabolic syndrome stage 0-3: a cohort study
This is a preprint of a study on insulin resistance and kidney disease. It looks at people with a specific metabolic syndrome. There are no results in the record yet.
Real-world epidemiology and renal outcomes of ADPKD in Türkiye: the PKD-TURK cohort.
This large study tracked kidney function in people with polycystic kidney disease in Turkey. It looked at how fast kidney filtering rates dropped over time. The study shows a link...
Cardiovascular Risk Factors in Adults with Type 2 Diabetes Mellitus: A Retrospective Study
This study looked at 518 adults with type 2 diabetes. It checked for risk factors that can hurt the heart and blood vessels. The study shows a link between diabetes control and...
Real-world safety profile of finerenone in patients with type 2 diabetes and chronic kidney disease: a multi-database pharmacovigilance analysis of the FAERS and JADER systems
This review checked safety reports for a drug called finerenone. It looked at data from the U.S. and Japan to see if the drug causes side effects in real life. The study shows a...
Kidney Involvement in Primary Sjögren Syndrome: Focus on Tubulointerstitial Nephritis
This study looked at kidney tissue from people with Sjögren's syndrome. It compared their kidney scarring to scarring from other causes. The study shows a link between this disease...
INTENSIVE VERSUS STANDARD SYSTOLIC BLOOD PRESSURE TARGETS: EVIDENCE, BENEFITS AND HARMS – A LITERATURE REVIEW
This review looks at past studies on blood pressure goals. It discusses whether aiming for lower numbers helps or hurts people. It is a summary of existing research, not a new...
Meeting a Proposed Estimated Glomerular Filtration Rate Slope-Based Criterion for Clinical Remission of Chronic Kidney Disease During Sequential Kidney-Protective Therapy in Type 2 Diabetes Mellitus: A Case Report
This report describes one man with diabetes and kidney disease. His kidney function improved after he took a series of protective drugs. This is a single case, so it does not prove...
SGLT2 INHIBITORS IN CHRONIC KIDNEY DISEASE WITH AND WITHOUT DIABETES: RENAL AND CARDIOVASCULAR OUTCOMES – A LITERATURE REVIEW
This review summarizes major trials on a class of drugs called SGLT2 inhibitors. It looks at how these drugs protect the kidneys and heart. It is a summary of existing research,...
Combination finerenone and empagliflozin for chronic kidney disease with type 2 diabetes: a target trial emulation
Researchers looked at records from three hospitals in China. They compared people taking two kidney-protecting drugs together against people taking just one. The group taking both...
EXPRESS: Comprehensive assessment of the cerebral pressure-flow relationship in chronic kidney disease
This study looked at how blood pressure affects blood flow to the brain in people with kidney disease. It involved 17 adults with kidney disease and 17 healthy controls. The...
Persistent Opioid Exposure in Older Adults with Rheumatic Disease: National Patterns, Disparities, and Cross-Specialty Prescribing.
This report looks at how often older adults with joint disease use opioid painkillers. It is a review of past records, not a test of a new treatment. It shows who uses these drugs,...
A Novel <i>LAMA5</i> Variant in Adult-Onset Focal Segmental Glomerulosclerosis: A Case Report.
This is a report on one young man who had a rare genetic change linked to kidney scarring. It is a single case, so it shows a possible link, not proof of cause. It helps doctors...
A Small Dose With Large Movements: Suspected Gabapentin-Associated Mixed Hyperkinetic Movement Disorder in End-Stage Renal Disease: A Case Report
This report describes one person with kidney failure who had unusual body movements. The doctors suspect a common pain medicine called gabapentin caused the issue. There are no...
Adiposity and the risk of aortic dissection incidence and mortality: results from the UK Biobank, the J-SHC study and a meta-analysis of cohort studies.
This large study looked at body fat and the risk of a torn aorta. It followed over 1 million people. It shows a link, but it does not prove that body fat causes the tear.
Clinical similarity, economic divergence: cost-effectiveness and population health implications of dietary, pharmacological, and exercise interventions in older adults with type 2 diabetes: a secondary analysis of a randomized controlled trial.
This study looked at 100 older adults with diabetes. It compared a diet, a drug, and exercise. It is a small trial, so the results are not strong proof.
Supplement Safety When Kidney Function Is Reduced
This is a safety article about supplements for people with kidney disease. It reviews past studies but is not a peer-reviewed journal article. It reports no new results of its own.
Managing Uncertainty in Health Self-Care Systems: A Neutrosophic Approach for Recommending Diets to Chronic Kidney Disease Patients
This paper describes a new app to help kidney patients with diet. It is a preprint, so it has not passed peer review yet. There are no final results to report.
What are the risks and benefits of creatine?
This paper discusses the use of creatine supplements for muscle strength. It notes that creatine is generally safe but can raise certain kidney markers. It suggests regular...
Comparative effects of exercise modalities on sleep quality in middle-aged and older adults with sleep disorders: A systematic review with pairwise, network, and dose-responsemeta-analyses.
This large review looked at many studies on exercise and sleep. It found that different types of exercise can help older adults sleep better. The review compared how much exercise...
Stable chronic hemodialysis porcine model via renal vein catheterization of the posterior vena cava
This study created a model in pigs to test dialysis devices before they are used in people. The pigs had their kidneys removed and were put on dialysis for up to 39 days. This was...
FAP-targeting CAR T cells with constitutive IL-10 expression reduce kidney fibrosis in mice
A new immune cell therapy reduced kidney scarring in mice. This was a lab study in animals, not people yet. It shows a promising path for future treatments.
Exosome-Mediated Cellular Injury in Diabetic Nephropathy: Mechanisms and Research Progress
This review explains how tiny cell bubbles called exosomes cause damage in diabetic kidney disease. It covers how these bubbles affect kidney cells and cause scarring. It is a...
Formulation and Development of Ligustrazine-Loaded Liposomes: A promising Drug Repurposing Approach for treating Nephrotoxicity
This study describes a new way to deliver a drug using tiny fat bubbles. It aims to treat kidney damage from toxins. It is a lab-based development, not a patient trial.
How Important Is the Concept of ‘Self-Esteem’ in the Context of Living Kidney Donation?
This is a commentary on a study about self-esteem in people who donate a kidney. It reviews findings from 17 centers in two countries. As a commentary, it does not report new data...
The Natural Course of Peri graft Fluid Collections After Kidney Transplantation: A Serial Imaging Cohort Study.
This preprint tracks fluid buildup around the new kidney in 146 transplant patients. It looks at how often this happens and how it is managed. It is a preprint, so it has not...
Successful renal retransplantation after structured optimization in a patient with diffuse systemic venous thrombosis and complex urological pathology: a case report
This report describes one patient who had a second kidney transplant. The patient had many serious health problems, including blood clots and scarring in the urinary tract. The...
“There’s No Goal…Except That We Take Care of Them”: Meeting the Needs of People Whose Kidney Failure is Managed Conservatively
This article discusses how doctors care for people with kidney failure who do not want dialysis. It notes that these patients are often overlooked in standard care. The piece is a...
Availability of age-stratified evidence for GLP1 receptor agonists and SGLT2 inhibitors: an analysis of European public assessment reports with a focus on older patients
This review looked at 185 trials of common diabetes drugs. It found that older adults are often left out of these studies. It shows a gap in the data, not a new treatment result.
A MULTIVARIABLE PREDICTION MODEL AND AN INTEGRATED PERIOPERATIVE ALGORITHM FOR CARDIAC SURGERY-ASSOCIATED ACUTE KIDNEY INJURY IN YOUNG CHILDREN
This paper describes a new tool to help doctors predict kidney injury in young children after heart surgery. It is a preprint, so it has not passed peer review yet. There are no...
PREOPERATIVE AND INTRAOPERATIVE RISK FACTORS FOR CARDIAC SURGERY-ASSOCIATED ACUTE KIDNEY INJURY IN YOUNG CHILDREN WITH CONGENITAL HEART DISEASE
This paper looks at risk factors for kidney injury in children with heart disease. It is a preprint, so it has not passed peer review yet. There are no final results to report.
How do patients with chronic kidney disease perceive the communication and support from their healthcare providers?
This paper explores how kidney patients feel about their doctors. It is a preprint, so it has not passed peer review yet. There are no final results to report.
Toward Explainable AI for Acute Kidney Injury Prediction in the ICU: Transparent Development, Internal Validation, and Robustness Auditing of Machine Learning Models
This study built a computer program to predict kidney injury in the ICU. It is a preprint, so it has not passed peer review yet. There are no final results to report.
MORPHOLOGICAL SUBSTRATE OF CARDIAC SURGERY-ASSOCIATED ACUTE KIDNEY INJURY IN YOUNG CHILDREN: CLINICO-MORPHOLOGICAL CORRELATIONS WITH BIOMARKERS AND PERFUSION PARAMETERS
This paper looks at how heart surgery affects the kidneys in young children. It aims to link the physical damage in the kidney tissue with blood test results. The text provided is...
Navigation and Care Coordination Across the Kidney Healthcare Trajectory: A Scoping Review Protocol
This is a plan for a review of how people with kidney disease get help moving through the healthcare system. It will look at how care teams coordinate and support patients. There...
LESÃO RENAL AGUDA EM ADULTOS HOSPITALIZADOS: FATORES DE RISCO, RECONHECIMENTO PRECOCE E ESTRATÉGIAS DE PREVENÇÃO
This article reviews how to spot and prevent sudden kidney injury in adults who are in the hospital. It looks at risk factors and early warning signs. The paper summarizes existing...
"Comprehensive Evaluation of Hematological, Biochemical and Inflammatory Markers in Relation to Estimated Glomerular Filtration Rate (eGFR) in PreDialysis Chronic Kidney Disease Patients"
This study compared 40 people with kidney disease to 20 healthy people. It found that the sick group had lower kidney function and higher signs of inflammation. This shows a link...
Phosphorylated Tau 217 Varies With Kidney Function Even Without Chronic Kidney Disease
This preprint found that a blood test for brain disease can give false alarms in people with mild kidney issues. It shows that kidney function affects the test results even before...
MEDA-PKD: a dynamic, real-time analytics platform for precision care in autosomal dominant polycystic kidney disease
This item describes a new digital tool for tracking polycystic kidney disease. It combines patient data and research data into one platform. It is a tool description, not a report...
Kidney Week Is Happening Now!
Kidney Week 2026 is taking place in Denver, Colorado. This is the main yearly meeting for kidney doctors and researchers. It is an event announcement, so there are no new study...
https://www.kidney.org/news-stories/nkf-joined-hhs-roundtable-improving-kidney-care
The National Kidney Foundation joined a government meeting to talk about better kidney care. This is a news story, not a research study. There are no results yet.