← brief for 2026-10-21 · Regeneration & devices

FAP-targeting CAR T cells with constitutive IL-10 expression reduce kidney fibrosis in mice

Article D Peer reviewed Preclinical

Key takeaways

A new immune cell therapy reduced kidney scarring in mice. This was a lab study in animals, not people yet. It shows a promising path for future treatments.

Who did this work

Blake D. Jardin (University of Pennsylvania) · Feiyan Liu (University of Pennsylvania) · Li Li (University of Pennsylvania) · Cheryl L. Smith (University of Pennsylvania) · Jonathan A. Epstein (University of Pennsylvania)

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-10-20
https://doi.org/10.1172/jci210355