Kidney research, 2026-10-17
New data shows a drug may help with dialysis itching.
Today's news focuses heavily on the symptom of itching in people on dialysis. One small trial offers a potential new treatment option, while a large survey confirms how common and burdensome this symptom is. Other reports cover kidney decline in diabetes and general care updates.
Dyslipidemia and Kidney Stone Risk: Mechanisms, Clinical Evidence, and Therapeutic Considerations
This article reviews how high cholesterol and other fats in the blood may link to kidney stones. It explains the body processes involved but does not report new test results. It is...
FGF23 and 20-HETE in Chronic Kidney Disease: From Clinical Association in Hemodialysis Patients to Podocyte Effects
This is a data file for a study on kidney disease and dialysis. It holds the numbers from the research but is not the main article itself. It does not report new findings on its...
Association of Serum Visfatin Levels with Coronary Artery Disease and Biochemical Parameters in Patients Undergoing Maintenance Hemodialysis
This study looked at 130 people, including those on dialysis. It found a link between a blood protein called visfatin and heart disease. This shows a connection, but it does not...
A gentler squeeze: A first signal from OCE-205, a selective V1a mixed agonist–antagonist for hepatorenal syndrome–acute kidney injury
This article discusses a new drug called OCE-205 for liver and kidney failure. It shares early signals from testing but does not provide full results yet. The study is still in...
Association of baseline non-severe anemia with clinical outcomes following the first recorded diagnosis of systemic sclerosis
This study looked at people with a skin and organ disease called systemic sclerosis. It checked if low red blood cell counts at diagnosis linked to worse outcomes. It shows a link,...
Long forms of cardiac troponin T are independent of kidney function and improve the diagnosis of myocardial infarction
This study looked at a new heart test for people with kidney issues. It found the test works well even when kidney function is low. This shows a link, not proof of cause.
Complete remission of minimal change disease after antiviral monotherapy in a patient with immune-active chronic hepatitis B
This is a report on one person with a rare kidney condition. The person took a virus drug and their kidney disease went away. This is a single case, not a large study.
Tenascin X and Tenascin C Serum Levels in Relation to Age and Cardiometabolic Risk Parameters
This study measured two proteins in the blood of 274 people. It found that one protein level dropped as people got older. This shows a link, not proof of cause.
Oxidative Stress and Mitochondrial Dysfunction in the Development and Progression of Kidney Outcomes: A Systematic Review
This is a review of studies on kidney disease in people with HIV. It looks at how cell damage might drive the disease. There are no new results in this document.
[Systemic sclerosis with anti-human neutrophil cytoplasm antibody associated vasculitis: A case report].
This is a report on one person with two rare autoimmune diseases. The person had bleeding in the lungs and brain. This is a single case, not a large study.
Inflammatory–Metabolic–Endothelial Crosstalk in Cardiovascular-Kidney-Metabolic (CKM) Syndrome: Molecular Mechanisms, Biomarkers, and Therapeutic Targets
This is a review of how heart, kidney, and metabolism problems are linked. It looks at the shared causes of these diseases. There are no new results in this document.
Young-onset Chronic Kidney Disease with Biopsy-proven Chronic Tubulointerstitial Nephritis and a Rare REN Variant, with Coincident Drug-related Erythrocytosis: A Case Report
This report describes one young man with kidney disease caused by a rare gene change. It is a single case, not a large study, so it does not prove a general rule. There are no...
The NLRP3 Inflammasome Across the AKI–AKD–CKD Continuum: Mitochondrial, Epigenetic and Endocrine–Metabolic Regulation
This review explains how a specific cell system drives kidney damage. It summarizes existing science but does not report new trial results. It is useful for understanding the...
Potential role of CTHRC1 in renal fibrosis
This article discusses a protein that may play a role in kidney scarring. It is a theoretical review and does not present new human trial data. It helps explain how kidney tissue...
CARDIORENAL RISK IN PATIENTS WITH ATRIAL FIBRILLATION AND CHRONIC KIDNEY DISEASE IN ARID REGIONS
This paper discusses using AI to predict risks for people with both heart and kidney issues in hot, dry climates. It is a preprint or working paper, so it has not passed full peer...
Association between the uric acid to high-density lipoprotein cholesterol ratio and diabetic kidney disease in U.S. adults with type 2 diabetes
In a large group of 4,010 people with type 2 diabetes, a specific blood test ratio was linked to kidney damage. This shows a connection, but it is not proof that the ratio causes...
Biochemical abnormalities related to CKD–MBD and bone mineral density in patients with chronic kidney disease stages 3–5: A cross-sectional study
This study looked at 128 people with advanced kidney disease to check their bone health and blood levels. It found common issues with minerals and bones. This shows a link between...
The Association of Kidney Function and Cardiovascular Disease Indices with Pro-Oxidant and Antioxidant Markers in CKD
This study looked at 477 adults with chronic kidney disease and 20 healthy controls. It found a link between certain blood markers of oxidative stress and kidney function. It also...
Gut-heart-kidney communication in cardiovascular disease: from a single-metabolite hypothesis to a context-dependent metabolite network
This is a review article that discusses how the gut, heart, and kidneys talk to each other. It argues that we should look at a whole network of gut chemicals, not just one. There...
Management and outcomes of urosepsis due to urolithiasis: a retrospective observational study at a tertiary hospital
This study looked at people with kidney stones who developed a serious infection called urosepsis. It reviewed records from 2017 to 2025 at one hospital. It shows which factors led...
Gut‑kidney axis in chronic kidney disease: Dysbiosis, uremic metabolites and therapeutic opportunities (Review)
This is a review article about the connection between the gut and the kidneys. It discusses how gut bacteria and waste products affect kidney disease. There is no abstract...
Changes in Laboratory Indicators of Anemia Depending on the Stages of Chronic Kidney Disease
This study followed 145 patients with stage 3 to 5 kidney disease. It found a strong link between kidney function and anemia markers. As kidney function drops, anemia gets worse....
Metabolically Unhealthy Obesity: Novel Subtypes Defined by Integrated Metabolomics and Hematology
This study looked at 62,341 obese participants from the UK Biobank. It identified four subtypes of unhealthy obesity based on blood and metabolic markers. It found that some...
Triglyceride-glucose-Chinese visceral adiposity index (TyG-CVAI) outperforms other TyG-derived indices in predicting 5-year advanced cardiovascular-kidney-metabolic syndrome: a prospective community-based cohort and machine learning study in China
This study used a community-based cohort in China to test different blood markers. It found that one specific index, called TyG-CVAI, was the best at predicting advanced kidney and...
Real-World Renal Effects of Dapagliflozin in Bulgarian Patients with Chronic Kidney Disease of Predominantly Glomerular Origin: A Two-Year Comparative Cohort Study with Historical Controls
This study compared 147 patients taking dapagliflozin with 170 past records. It looked at kidney function and protein in the urine over two years. The group on the drug had better...
Incidence and Risk Factors of Contrast-Associated Acute Kidney Injury Following Contrast-Enhanced CT: A Retrospective Study
This study looked at people who had a CT scan with contrast dye. It found the rate of acute kidney injury after the scan. It also identified risk factors for this injury. This is...
Clinical Features and Genetic Diversity of Primary Hyperoxaluria: A Case Series Analysis of Chinese Patients.
Thirteen patients with a rare genetic kidney disease were reviewed. The study describes their symptoms and how the disease affected their kidneys. This is a small observational...
Acute kidney disease after acute kidney injury: incidence, risk factors, and association with de novo chronic kidney disease
A study of 23,868 patients found that 45.6% of those with sudden kidney injury went on to have longer-term kidney disease. This is an observational study, so it shows a link, not...
Estimated Glomerular Filtration Rate Slope, Chronic Kidney Disease Progression, and Pillars of Care in Patients With Diabetic Kidney Disease.
This study looks at how kidney function declines in people with diabetes. It tracks the drop in kidney filtering rate over time. It discusses how newer drugs can help slow this...
Protective Role of Trans-chalcone against Kidney Injury Induced by High-Fat Diet: Exploring the Possible Involvement of FABP4 and Endoplasmic Reticulum Stress.
This study used animals to see if a plant compound called trans-chalcone protects kidneys from a high-fat diet. It found that the compound may reduce kidney stress. This was in...
Renal microcirculation in acute kidney injury: bridging haemodynamics, inflammation and repair.
This review explains how the tiny blood vessels in the kidneys work. It describes how these vessels can get damaged during sudden kidney injury. It is a summary of existing...
Modern Obesity Treatment: Efficacy, Safety, and Future Directions of GLP-1 (Glucagon-Like Peptide-1) and GIP (Glucose-Dependent Insulinotropic Polypeptide) Receptor Agonists.
This review summarizes what is known about weight-loss drugs and their effects on the body. It discusses how these drugs help with weight and may protect the kidneys. There are no...
Beyond Protein Restriction: Comparative eADI-17-Estimated Anti-Inflammatory Profiles of Four Renal Diets
This study compared four meal plans for people with kidney disease. It used a score to guess how much each diet might cause inflammation. The Mediterranean diet had the lowest...
Integrated network toxicology, transcriptomic, and Mendelian randomization analyses explore potential molecular links between acrylamide exposure and clear cell renal cell carcinoma.
This study used computer models to link a food chemical to kidney cancer. It looked at genes and proteins in the body. This is a lab-based prediction, not a test in people yet.
Nutritional assessment and dietary intake patterns in early-stage chronic kidney disease: a hospital-based cross-sectional study
Researchers looked at the diets of 184 people with early-stage kidney disease. They found patterns in what these patients ate and their nutritional status. This shows a link...
Dietary inflammatory index and body shape index and mortality risk in early-stage cardiovascular–kidney–metabolic syndrome: evidence from NHANES
This study used data from 32,976 adults with early-stage kidney and heart issues. It looked at how diet and body shape affect the risk of death. It found a link between...
Chronic Kidney Disease-Associated Pruritus in Danish Dialysis Patients: A Cross-Sectional Multicenter Study of Prevalence, Disease Burden, and Current Treatment Practices.
This study looked at how common itching is among people on dialysis in Denmark. It found that many patients suffer from this symptom, which can lower their quality of life. Because...
DIalysis Symptom COntrol-Pruritus Outcome Trial (DISCO-POT): A Multicenter Randomized Blinded Placebo Controlled Crossover Trial.
A new trial tested a drug called nabilone to help with itching in people on dialysis. The study was small, involving a limited number of participants over a few weeks. The results...
Effect of uric acid and estimated glomerular filtration rate on the Fibrosis-4 index: A cross-sectional and cohort analysis.
This study looked at 5,051 adults with fatty liver disease. It found that kidney function and uric acid levels are linked to how much scarring is in the liver. This is an...
Platelet-derived microparticles induce CD8+ T cell senescence in chronic kidney disease via the transfer of microRNA-550a-5p
This study used cells from people with kidney disease. It found that small bits from blood platelets can make immune cells age too fast. This happens in the lab, not in people yet....
Processed Data for: Chronic Nephropathy in African Spurred Tortoises (Centrochelys sulcata) Is Associated with Depletion of Six2+ Renal Progenitor Cells, Transcriptional Silencing of Nephrogenic Gene Networks, Mitochondrial Dysfunction, and Loss of Neonephrogenic Capacity
This item shares the data from a study on 21 tortoises with kidney disease. The researchers looked at how kidney cells change in these animals. They found that the cells that help...
Base Editing as a Therapeutic Strategy for Autosomal Dominant Tubulointerstitial Kidney Disease caused by Pathogenic UMOD Variants
This study tested a gene-editing tool in cells and 3D kidney models. It fixed a specific gene error that causes a rare kidney disease. The tool worked in up to 83.4% of the cells...
Persistent hyperparathyroidism and its predictive factors in end-stage renal disease patients after kidney transplantation
About 59% of 104 people still had high parathyroid hormone levels six months after a kidney transplant. This study shows a link between certain factors and this condition, but it...
[Correlation between acute kidney injury diagnosed by serum creatinine and urine output criteria and short-term prognosis in critically ill patients following non-cardiac surgery].
This is a secondary analysis of data from a previous study. It looks at how kidney injury is diagnosed in surgery patients. There are no new trial results in this specific record.
What is the recommended dosage of a 37.5 mg tramadol hydrochloride and 325 mg paracetamol combination for a patient with chronic renal insufficiency?
This document offers advice on how to dose a pain medicine for people with kidney disease. It suggests taking no more than two tablets every 12 hours if kidney function is very...
Cutaneous Lesions, Severe Hypercalcemia and Acute Kidney Injury Revealing Sarcoidosis: A Case Report with Atypical Histology and Corticosteroid-Induced Diabetes
This is a single case report of a woman whose kidney injury and high calcium levels were caused by sarcoidosis. It describes one person's experience, not a large study.
High sensitivity C-reactive protein and the risk of cardio-kidney outcomes in adults with moderate to severe chronic kidney disease: a nationwide study
In a large group of 23,008 adults with kidney disease, high levels of a blood inflammation marker were linked to worse heart and kidney outcomes. This shows a link, not proof of...
Proliferative glomerulonephritis with monoclonal IgM-kappa deposits responsive to daratumumab therapy—a case report
This is a single case report of a woman with a rare kidney disorder who responded to a specific drug. It describes one person's experience, not a large study.
APPROACHES TO EARLY DETECTION OF ARTERIAL HYPERTENSION
This is a narrative review of how to detect high blood pressure early. It summarizes existing guidelines, not new study results.
Predictors of Early Mortality After Open Aorto-Iliac Reconstruction in Patients with Aortoiliac Occlusive Disease: An Observational Cohort Study
In a group of 170 patients who had leg artery surgery, certain factors were linked to a higher risk of dying within 30 days. This shows a link, not proof of cause.
IgG4-related lesion of the retroperitoneum, ureter, and kidney, mimicking infiltrating endometriosis
This report describes one person with a rare kidney condition. The disease looked like endometriosis, which is tissue that grows outside the uterus. Doctors had to use tests to...
Analysis code, frozen outputs, and trained models for the NHANES diabetic kidney disease fairness audit
This is a data package for a study on how fair computer models are. It checks if these tools work the same for all groups of people. There are no new medical results in this file.
Landscape of posterior urethral valve management in Africa: current practices, challenges, and prospects in referral centres
This study surveyed 31 centers in 17 African countries about treating a birth defect in boys. It highlights gaps in care and resources. It shows a link between location and access...
Surgical management of presternal recurrence in hyperparathyroidism related to chronic kidney disease
Twenty-four people with kidney disease had a second surgery because their parathyroid glands came back after a first operation. The study tracks how well this second surgery...
Early parathyroid hormone elevation after denosumab therapy following parathyroidectomy: a diagnostic pitfall.
This is a case report about one 77-year-old woman. It describes how a bone drug can change hormone levels after surgery. It is a single patient story, not a large study with...