← brief for 2026-10-17 · Regeneration & devices

Base Editing as a Therapeutic Strategy for Autosomal Dominant Tubulointerstitial Kidney Disease caused by Pathogenic UMOD Variants

Preprint D Not peer reviewed Preclinical

Key takeaways

This study tested a gene-editing tool in cells and 3D kidney models. It fixed a specific gene error that causes a rare kidney disease. The tool worked in up to 83.4% of the cells tested. This is a lab result, not a test in people yet.

Who did this work

Nora Diederich (Humboldt-Universität zu Berlin) · Sarah Wendlinger (Humboldt-Universität zu Berlin) · Shuhan Kong (Humboldt-Universität zu Berlin) · Dimitra Papaioannou (Humboldt-Universität zu Berlin) · Emily Haar (Humboldt-Universität zu Berlin) · Amr Al‐Shebel (Humboldt-Universität zu Berlin) · Guy Yealland (Humboldt-Universität zu Berlin) · Wenjun Jin (Humboldt-Universität zu Berlin) · Carlos Cordero Oropeza (Humboldt-Universität zu Berlin) · Ria Anne-Rose Schönauer (Humboldt-Universität zu Berlin) · Roberta Di Costanzo (Azienda USL di Bologna) · Marta Mariniello (University of Zurich)

Source

Preprint · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-10-16
https://doi.org/10.64898/2026.10.15.758759