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Platelet-derived microparticles induce CD8+ T cell senescence in chronic kidney disease via the transfer of microRNA-550a-5p

Article D Peer reviewed Preclinical

Key takeaways

This study used cells from people with kidney disease. It found that small bits from blood platelets can make immune cells age too fast. This happens in the lab, not in people yet. It may explain why kidney patients get sick more often.

Who did this work

Yuewen Sun · Qigang Lan · Yaqin Wang · Minhua Xie · Xinyi Wu · Liangjing Lv · Qing Xin · Jun Chen · Xiaoyi Zhong · Mengying Yao · Shuiqin Gong · Siyan Zhou

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-10-16
https://doi.org/10.1038/s12276-026-01876-z