Kidney research, 2026-10-13
A new tool may help doctors spot which kidney patients are at higher risk.
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Most other reports today were preliminary or focused on animals, so they do not change daily care for people with stage 3 CKD.
Today's news is mostly about tools and reviews rather than new cures. The most useful item is a test of a prediction model that helps doctors identify patients who might need closer monitoring. Other items look at how common drugs affect the body or how liver failure links to kidney issues. None of these findings require a change in your current treatment plan.
Cardiovascular–kidney–metabolic syndrome and cancer
This article discusses the link between heart, kidney, and metabolic health and cancer. It suggests that shared pathways might be a target for prevention. There are no new results...
Endothelial Dysfunction and Microcirculatory Impairment as a Unifying Pathway of Post-COVID-19 Organ Injury: From Vascular Inflammation to Hypoxic Tissue Remodeling
This review explains how the virus can damage blood vessels after a person recovers from COVID-19. It is a summary of past research, not a new trial. It helps explain why some...
Hematologic Responses to Molidustat in Cats with Anemia of Heterogeneous Etiology: A Retrospective Descriptive Study
This study looked at 39 cats with low blood counts, some of which had kidney disease. It tested a drug called molidustat. This was done in animals, not people, so the results may...
Treatment Considerations for Selecting Biologic and Targeted Synthetic DMARDs in Patients with Rheumatoid Arthritis with Comorbidities: An Indian Perspective
This paper discusses how to choose arthritis drugs for patients who also have other health issues, like kidney problems. It is a guide for doctors, not a new study. It helps with...
Cardiovascular And Renal Benefits of Sodium–Glucose Cotransporter 2 Inhibitors in Patients Without Diabetes: A Review of Current Evidence
This review looks at how SGLT-2 drugs help the heart and kidneys in people who do not have diabetes. It is a summary of past studies, not a new trial. It suggests these drugs may...
Glutamine metabolic reprogramming in acute and chronic kidney diseases: mechanistic insights and therapeutic implications
This review looks at how a nutrient called glutamine changes in people with kidney disease. It is a summary of past research, not a new trial. It aims to find new ways to treat...
Mitochondrial Dysfunction Across Renal Compartments in Diabetic Kidney Disease
This paper explains how diabetes affects the tiny energy factories inside kidney cells. It is a review of existing science, not a new test on people. It helps doctors understand...
Effects of Sodium-Glucose Cotransporter Type 2 Inhibitors on Residual Kidney Function in Patients Undergoing Incremental Hemodialysis: A Two-Center, Retrospective, Exploratory Cohort Study
This study looked at people on dialysis who took a type of diabetes drug called an SGLT-2 inhibitor. It tracked how much kidney function they kept over 12 months. Because it was an...
Real-World Effects of GLP-1 Receptor Agonists and SGLT2 Inhibitors on Gout Outcomes and Metabolic Profiles
This study looked at 64 people with gout. It compared different diabetes drugs over two years. It shows a link between these drugs and gout outcomes, but it is not proof of cause.
Prevalence of chronic kidney disease among patients co-infected with COVID-19 and HIV at the University of Ilorin Teaching Hospital, Ilorin, Nigeria: a cross-sectional study
This study checked 423 people with HIV and COVID-19. It found that many of them also had kidney disease. This shows a link, but it does not prove that one causes the other.
Epigenetic and mitochondrial regulation in kidney disease: emerging mechanisms and therapeutic opportunities
This review looks at how cell energy and gene control affect kidney scarring. It explains the biology in detail. These findings are from cells and animals, not people yet.
Temporal trends and disparities in mortality involving chronic kidney disease and malnutrition among U.S. adults, 1999–2024: a nationwide population-based study
This study looked at death records from 1999 to 2024. It found that people with kidney disease and poor nutrition have higher death rates. This shows a link, but it does not prove...
Joint prediction of chronic kidney disease severity and renal function biomarkers using attention-driven multi-task learning
Researchers built a computer program to predict how bad kidney disease is. It looks at three signs at once to spot problems early. This is a new tool, so there are no results from...
A case of renal hypouricemia type 1 associated with compound heterozygous URAT1/SLC22A12 variants A209V and F379L: clinical evidence for their pathogenic significance
A 69-year-old woman had very low levels of uric acid in her blood. Doctors found two specific gene changes that caused this rare kidney condition. This is a single case report, not...
Organelle contact sites as intracellular communication hubs linking metabolic stress to inflammatory disease
This review explains how tiny parts inside cells talk to each other. It shows how cell stress can lead to long-term inflammation. This is a basic science review, not a test in...
What are the complications of plasmapheresis treatment in patients with cryoglobulinaemic vasculitis?
This review looked for side effects of a blood-filtering treatment called plasmapheresis. It focused on people with a rare blood vessel disease. The authors found no direct proof...
Cardiorenal anemia syndrome as an independent predictor of inhospital complications in acute coronary syndrome
This study followed 210 patients with heart attacks. It found that having both low blood counts and kidney issues linked to more complications in the hospital. This shows a link,...
Calprotectin Accelerates Pathogenic Calciprotein Particle Maturation to Promote Vascular Calcification in Chronic Kidney Disease
This study used mice to show that a protein called calprotectin speeds up the hardening of blood vessels. This hardening is a major cause of heart problems in kidney disease. The...
Progress on the related mechanisms of vascular calcification in autogenous arteriovenous fistula in hemodialysis patients
This paper reviews how blood vessels harden in dialysis patients. The full details are not available in this record, so no results are reported here.
Hemodialysis for severe diabetic ketoacidosis-related acidosis without AKI or ESKD: incidence and outcomes in a single-center study
This study looks at dialysis for a specific type of acid buildup in diabetes. The full details are not available in this record, so no results are reported here.
Associations Between Serum Osteocalcin and Metabolic, Nutritional, and Hormonal Status in Male Patients with Chronic Kidney Disease: A Cross-Sectional Study
This study looked at 144 men to see how a bone protein links to kidney health. It found that men with lower kidney filtering rates had higher levels of this protein. This shows a...
SGLT2 Inhibitors Reduce Heart Failure Hospitalization, Cardiovascular Death and Kidney Outcomes in Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials.
This review combined results from many large drug trials. It found that SGLT2 inhibitors lower the risk of heart failure and kidney decline. These drugs also reduce the chance of...
The Effects of GLP-1RA-Based and SGLT2 Inhibitor Therapy on Perirenal Adipose Tissue in CKD Patients.
This study looked at the fat that surrounds the kidney in people with chronic kidney disease. It used ultrasound to measure this fat in people taking certain diabetes drugs. The...
A Study of Luspatercept in People With Anemia
A new trial is starting to test a drug called luspatercept. It aims to improve low blood count in people with kidney disease. There are no results yet. The study will also check if...
Glucagon-like Peptide-1-based and Emerging Cardiometabolic Therapies in Heart Failure with Preserved Ejection Fraction: Linking Molecular Mechanisms to Clinical Outcomes.
This review discusses new drugs for heart failure. It links these drugs to kidney and metabolic health. It is a summary of existing research, not a new trial with results.
Effects of tirzepatide (GIP/GLP-1 dual receptor agonist) on cardiorenal biomarkers and functional capacity in heart failure: a systematic review and meta-analysis.
This large review combined data from several studies on the drug tirzepatide. It looked at how the drug affects heart and kidney markers in people with heart failure. It found that...
Characteristics of Youth With Type 2 Diabetes Prescribed Sodium-Glucose Cotransporter-2 Inhibitors Surrounding FDA Approval at an Academic Pediatric Medical Center.
Doctors at one children's hospital started prescribing a new diabetes drug to more kids after it was approved. This drug helps lower blood sugar and may protect the kidneys. The...
Racial, sex, and geographic disparities in mortality involving stroke and chronic kidney disease: a CDC WONDER database analysis, 1999-2020.
This review looked at death records from 1999 to 2020. It found that people with both stroke and kidney disease die at different rates based on race and sex. This shows a link...
An age-stratified semiquantitative urine ACR triage strategy for quantitative confirmation: a retrospective diagnostic accuracy study with temporal validation.
This study tested a new way to screen for kidney damage using urine tests. It suggests that the test should change based on a person's age. This helps doctors find early signs of...
Serum T50 is not independently associated with coronary artery calcification in early chronic kidney disease.
A blood test called T50 is used to check for bone hardening. This study found that the test does not predict heart disease in people with early kidney problems. It looked at 1,945...
Endothelial AGGF1 contributes to glomerular barrier dysfunction via TNFSF12/FN14-Src-VE-cadherin signaling in diabetic kidney disease.
This study looked at how a protein called AGGF1 affects the kidney's filter. It was done in mice and cells, not people yet. It found that this protein can damage the filter in...
Long-term metabolic regulation in the era of GLP-1 receptor agonists: An integrative review of Ayurvedic and biomedical perspectives.
This review looks at how GLP-1 drugs, like semaglutide, help with weight and kidney health. It also looks at how Ayurvedic medicine views these same issues. It shows a link between...
Validation of the Klinrisk CKD Progression Model in the Dapagliflozin and Prevention of Adverse Outcomes in CKD (DAPA-CKD) Population.
This study tested a computer model that predicts if kidney disease will get worse. It used data from the DAPA-CKD trial to check if the model works. It shows a link between the...
THE EFFECT OF THREE-MONTH MAGNESIUM REPLACEMENT ON PROTEINURIA IN HYPOMAGNESEMIC PATIENTS WITH CHRONIC KIDNEY DISEASE
Sixty-six people with kidney disease at stages 1 to 4, who also had low magnesium in their blood, took magnesium for three months. The researchers tracked protein in the urine, a...
Muscle strength, muscle mass, and physical performance in children and adolescents with chronic kidney disease: a systematic review and meta-analysis
This review combined many studies on children with kidney disease. It found that these kids often have weaker muscles and lower physical performance. This is a strong finding...
Study Protocol for the Daasanach Human Biology Project: A Longitudinal Study of the Impact of Drinking Water Salinity and Heat Stress on Water Insecurity, Hydration, Energetics, Hypertension, and Kidney Function in Northern Kenya.
This is a plan for a new study in northern Kenya. It will follow 600 adults to see how salty water and heat affect their kidneys and blood pressure. The study is just starting, so...
Medication-induced Micronutrient Deficiencies in Early-stage Chronic Kidney Disease.
This review discusses how common medicines can lower vitamin and mineral levels in people with early kidney disease. It is a summary of existing research, not a new trial. There...
Pleurotus nebrodensis Mushroom (Agaricomycetes) Polysaccharide Chewable Tablets Alleviate Adenine-Induced Chronic Kidney Disease: Efficacy Assessment and Formulation Optimization.
This study tested a mushroom extract in mice with kidney disease. It was done in animals, not people yet. It found that the extract may help protect the kidneys and reduce damage....
Efficacy of yoga and its probable mechanism of action on lifestyle-related chronic kidney disease: a randomized clinical trial.
This trial tested yoga in people with middle stage kidney disease, stages 3 and 4, caused by diabetes or high blood pressure. Eighty-one patients aged 35 to 60 at a hospital in...
Authors' Reply: Using Alzheimer's Disease Cerebrospinal Fluid Biomarkers in CKD: A Caution for Clinicians
This is a reply to a previous letter about using brain fluid tests in kidney disease. It is a discussion piece and does not report new study results.
Transformer-Convolution Pyramid Network for Multi-Class Kidney, Tumor, and Cyst Segmentation
This paper describes a new computer program that can find and outline kidneys, tumors, and cysts in CT scans. It is a tool for doctors to plan care, not a test of a new drug or...
Analytical Evaluation of Simulated Kidney-Disease Profiles: Comparison of a Portable Near-Infrared Spectrophotometer with a Benchtop FT-NIR
Researchers tested a small, portable light-based scanner for kidney disease. They compared it to a larger, standard lab machine. The test used mixed blood samples, not real...
RNA-sequencing data for Tissue-specific remodeling of branched-chain amino acid metabolism in kidney-heart-lung crosstalk after acute kidney injury
This is a data set from a study on how organs talk to each other after injury. It does not report any new findings or results yet.
ATACseq [SnapATAC] data from the kidney (right) of a 54-year-old white male
This is a data set from a single kidney sample. It does not report any new findings or results yet.
What is the best dialysis regimen for severe AKI to allow kidney function recovery?
This review asks how to help kidneys recover after sudden injury. It discusses dialysis and repair processes. It is a summary of existing research, not a new trial with results.
Caloric restriction alters early renal responses to reversible obstructive nephropathy in rats.
This study was done in rats, not people. It looked at how eating less affects kidney recovery after a blockage. It found that eating less did not help the kidneys recover faster in...
A review on recent advances in regenerative medicine for renal diseases: Approaches and challenges.
This is a review of recent research on repairing kidney tissue. It looks at stem cells and other new methods. It does not report new trial results. It summarizes what is being...
Dynamic course and outcomes of acute-on-chronic liver failure in the intensive care unit : Insights from a real-world cohort.
This study looked at 209 people with severe liver failure in the ICU. It tracked how their organs, including their kidneys, changed over time. It shows a link between liver failure...
Are we Asking the Right Questions When Assessing Glomerular Filtration Rate in Living Kidney Donors?
This paper discusses how we measure kidney function in living donors. It is a discussion piece and does not report new study results.
Cross-Cultural Adaptation and Initial Psychometric Evaluation of the Japanese Version of the Chronic Kidney Disease Self-Efficacy Scale (CKDSE-J)
Researchers translated a self-care confidence survey into Japanese. They tested it on 227 adults with kidney disease who are not on dialysis. The goal is to help doctors measure...
ATACseq [SnapATAC] data from the kidney (left) of a 45-year-old white female
This item is a data set from a healthy kidney. It is a research tool, not a study with results. There are no findings to report yet.
American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)
A long-term study is planned for 500 American Indian people. It aims to understand why kidney disease progresses in this group. There are no results yet. This study will help find...