← brief for 2026-10-13 · Slowing decline

Endothelial AGGF1 contributes to glomerular barrier dysfunction via TNFSF12/FN14-Src-VE-cadherin signaling in diabetic kidney disease.

Article D Peer reviewed Preclinical

Key takeaways

This study looked at how a protein called AGGF1 affects the kidney's filter. It was done in mice and cells, not people yet. It found that this protein can damage the filter in diabetic kidney disease. This helps explain how diabetes harms the kidney at a tiny level.

Who did this work

Zhang M · Cheng Y · Wu S · Li G · Tian L · Sun S · Miao Y · Deng X · Meng Z · Sun B · Chen L

Source

Article · PubMed, the drug frontier · 2026 Oct 13
https://pubmed.ncbi.nlm.nih.gov/42869327/