Kidney research, 2026-10-12
Two main drugs both slow kidney decline in people with type 2 diabetes.
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A new study suggests Nefecon works better than steroids for a common kidney disease, though this is a single real-world report.
Today's news focuses on how to protect kidney function. The strongest evidence confirms that two popular drug classes work well for people with diabetes. Other reports offer mixed results on new treatments and lifestyle changes. These findings help guide daily management but do not promise a cure.
Profile of Renal Involvement in Rheumatic Disorders: A Prospective Observational Study from a Tertiary Care Centre in North India
This study tracked patients with rheumatic diseases over 2.5 years. It looked at how often their kidneys were affected. It shows a link between these conditions and kidney issues,...
Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset
This study used mice to test a traditional Chinese medicine formula. It found the formula could reverse stress-related aging in the kidneys. This was done in animals, not people...
Personalized Contrast Dosing in TAVI: Weight-Adjusted Contrast Exposure and Renal Biomarker Changes in High-Risk Patients
This study followed 425 patients who had a heart valve procedure. It looked at how much contrast dye they received and how their kidneys reacted. It shows a link between dye dose...
Renal Dysfunction in Patients with Metabolic Syndrome in a Rural Indian Population: A Cross-Sectional Comparative Study
This study looked at people in rural India with metabolic syndrome. It found a link between this condition and lower kidney function. This is an observational study, so it shows a...
Long-Term Outcomes of Maintenance Peritoneal Dialysis Initiated During Infancy: A Temporally Aligned Comparative Study
This is a preprint about babies who start dialysis early. It compares their long-term health to others. It is not yet peer reviewed, and there are no broad results to share.
Whole-Genome Sequencing and Resistome Analysis of Multidrug-Resistant and Extensively Drug-Resistant Escherichia coli Isolated from Chronic Kidney Disease Patients in Baghdad, Iraq
This item is a record for a study on bacteria in kidney patients. It looks at how these germs resist drugs. There is no abstract or data available here, so there are no results to...
Abrupt Onset of Crescentic IgA Nephropathy Superimposed on Glycogen Storage Disease Type Ia: A 15-Year Longitudinal Pediatric Case Report
This is a preprint about one child with two rare conditions. It tracks their kidney health over 15 years. It is not yet peer reviewed, and there are no broad results to share.
Preoperative Kidney Vulnerability Before Major Abdominal Surgery: Current Concepts, Practical Risk Interpretation, and a Research Agenda
This article discusses how to check kidney health before big surgery. It is a review of current ideas and plans for future research. There are no new trial results in this piece.
Metformin alleviates renal fibrosis in unilateral ureteral obstruction rats by regulating mitophagy
This item is a record for a study on rats. It looks at how a common diabetes drug might reduce scarring in the kidneys. There is no abstract or data available here, so there are no...
Beyond Watchful Waiting: Earlier Intervention and Emerging Therapies in IgA Nephropathy
This article discusses new treatments for IgA nephropathy, a common cause of kidney disease. It is a preprint without an abstract, so specific study results are not available yet.
Admission-based predictors of in-hospital AKI in HFrEF: a single-centre retrospective study
Researchers analyzed 1,071 hospital stays for people with a type of heart failure. They created a model to predict sudden kidney injury during the stay. This is an observational...
Mortality and kidney outcomes in ANCA-associated vasculitis: determinants from a real-world cohort
This study reviewed records of 248 patients with a rare blood vessel disease called ANCA-associated vasculitis. It looked at what factors lead to death or kidney failure. As an...
Blood lead and cardiovascular mortality in never and ever smokers: a 20-year follow-up of US adults in NHANES 1999–2018
This study followed 41,629 adults for about 20 years. It found that higher lead levels in the blood were linked to more deaths from heart disease. This link held true even for...
Baseline anti-PLA2R antibody titer predicts treatment response and renal outcomes in rituximab-treated membranous nephropathy
This study found that a specific blood test level before treatment can predict how well a kidney drug works. It looked at 69 patients with a rare kidney disease. It shows a link...
Prognostic value of multiple biomarkers for kidney function decline in type 2 diabetes with relatively preserved kidney function: a systematic review and exploratory meta-analysis
This review looked at blood tests that may predict kidney decline in people with type 2 diabetes. It combined data from multiple studies to find which markers are most useful. This...
Clinical outcomes of sacubitril/valsartan in patients with mildly reduced or preserved ejection fraction and acute heart failure: a multi-institutional study.
This study looked at 9,107 patients with heart failure and kidney issues. It examined how a blood pressure drug worked in real-world settings. It shows a link between the drug and...
Arachidonic Acid Disrupts PKM2-Linked Glycolysis-Related Metabolism and Exacerbates PAN-Induced Podocyte Injury.
This study used rats to see how a fatty acid called arachidonic acid affects kidney cells. The researchers found that this fatty acid made kidney damage worse. It did this by...
Association of chronic kidney disease with major cardiovascular outcomes following lower extremity endovascular revascularization.
This study found that people with kidney disease had more heart problems after a leg procedure. It used data from a large registry. It shows a link, not proof of cause. This means...
Comparative Cardiorenal Efficacy and Safety of SGLT2 Inhibitors and Finerenone in Chronic Kidney Disease With Type 2 Diabetes: A Systematic Review and Network Meta-Analysis.
This review compared two kidney drugs, SGLT2 inhibitors and finerenone. It used data from 10 trials. Both drugs slowed kidney decline in people with type 2 diabetes. This is a...
Characterizing the Adverse Event Profile of Semaglutide: A Comprehensive U.S. Food and Drug Administration Adverse Event Reporting System-Based Pharmacovigilance Study.
This study looked at safety reports for semaglutide, a diabetes and weight loss drug. It used data from the FDA database. It shows what side effects people report, but it does not...
Risk factors for cardiovascular disease, chronic kidney disease, and type 2 diabetes in populations with overweight and obesity: an umbrella review and cohort analysis.
This large review found that being overweight raises the risk of kidney disease, heart disease, and diabetes. It combined many studies to find the main risk factors. Keeping a...
Chronic Pain in Autosomal Dominant Polycystic Kidney Disease and the Long-Term Effects of Increasing Water Intake.
People with polycystic kidney disease who drank more water had less pain over three years. The study included 184 people. It is a small trial, so the results need more testing....
Obesity as a Modifiable Driver of Cardiorenal Syndrome
This item is a record for a paper on weight and kidney health. It looks at how obesity affects the heart and kidneys. There is no abstract or data available here, so there are no...
Association of waist circumference trajectories with incident chronic kidney disease.
This study followed 5,429 adults to see if waist size changes link to new kidney disease. It found that increasing waist size was associated with a higher risk of developing kidney...
Physical activity attenuates mortality risk associated with elevated resting heart rate in chronic kidney disease.
This study looked at 12,042 patients with kidney disease. It found that being active helped lower the risk of death, even for people with a high resting heart rate. It shows a link...
MEDICAL REHABILITATION IN NEPHROLOGY AND AUTOGENIC TRAINING
This item is a record for a review on kidney rehabilitation. It covers exercise, diet, and relaxation techniques. There is no abstract or data available here, so there are no...
Spatial proteomics identifies altered thick ascending limb cells as drivers of kidney disease through uromodulin retention
This study used advanced tools to look at kidney cells in the lab. It found that a specific cell type may drive kidney disease. This was done in cells, not in people yet. It helps...
Enteric-gated nano–probiotic living nanozyme for gut-directed redox–mitochondrial protection in cisplatin-induced acute kidney injury
Scientists created a new treatment using bacteria and nanoparticles to protect kidneys from damage caused by a cancer drug. This work was done in cells and the lab, not in people...
Carbocisteine Confers Renoprotection in Streptozotocin-Induced Diabetic Nephropathy Through Sirt-1/Nrf-2-Dependent Inhibition of NLRP3 Inflammasome Activation.
This study found that a drug called carbocisteine protected the kidneys of rats with diabetes. It was done in animals, not people yet. The drug reduced inflammation and stress in...
A Miniaturized, Multilayer Structured Vertical Flow Paper Device Enabled One-Step, Multiplex, Spontaneous Detection of Biomarkers in Microliter Blood for Disease Screening.
This study created a small paper device that can check for kidney disease and other problems using a tiny drop of blood. It was tested in the lab, not in people yet. It could make...
Macrophage fate decisions during AKI-CKD transition insights from single-cell and spatial transcriptomics.
This study looked at how immune cells behave when the kidney is injured. It used advanced lab techniques on cells and tissues. It was done in the lab, not in people yet. It helps...
Intaermedin attenuates chronic intermittent hypoxia-induced renal fibrosis via SIRT1-mediated inhibition of the NOX4/ROS axis.
This study used mice and human kidney cells in the lab. It tested a small peptide called intermedin. It showed that this peptide can reduce scarring in the kidney. This was not...
Sociodemographic and Clinical Characteristics of Children with Kidney Transplantation Rejection: A Case-Control Study
This item is a record for a study on children who reject a kidney transplant. It compares their health to others. There is no abstract or data available here, so there are no...
Impact of donor kidney weight and recipient body mass index on long-term renal function decline following living donor kidney transplantation
This is a preprint about how the size of a donor kidney and the recipient's body weight affect kidney function over time. It is not yet peer-reviewed, and there is no abstract...
Risk factors for invasive fungal infections after kidney transplantation and the construction of a predictive model
Researchers looked at 997 people who received a kidney transplant. They built a tool to predict who is at high risk for serious fungal infections. This is an observational study,...
High tacrolimus intrapatient variability is associated with graft loss after kidney transplantation: a systematic review and meta-analysis
This review is planned to look at how changes in a common anti-rejection drug affect kidney transplants. It aims to see if unstable drug levels lead to transplant failure. There...
https://www.kidney.org/news-stories/colorado-s-approach-to-kidney-disease-prevention-entering-new-chapter
This news story discusses a new approach to preventing kidney disease in Colorado. It is a policy update, not a research study with results.
https://www.theisn.org/blog/2026/10/12/build-practical-skills-in-managing-aki-in-the-tropics-with-a-new-isn-academy-course/
The International Society of Nephrology is launching a new online course. It teaches doctors how to manage sudden kidney failure in tropical regions. There are no study results in...
Unmasking Iododerma: A Distinctive Histopathologic Pattern of Neutrophil‐Rich Dermatosis With Haloed Cryptococcoid Bodies in the Setting of Hydralazine Exposure and Autoimmune Serologic Abnormalities
This report describes two women with kidney disease who developed a rare skin reaction. The reaction was likely caused by a contrast dye used in imaging tests. The paper focuses on...
Quality of Life of Patients With Chronic Kidney Disease on Maintenance Hemodialysis in Selected Healthcare Institutions in Baguio City
This study asked 100 people on dialysis about their daily life. Most said they were moderately satisfied. It shows a link between dialysis and life satisfaction, but it does not...
Infiltrative urothelial carcinoma of the renal pelvis with metastases (MRI)
This is a case report of a rare kidney cancer shown in MRI images. It describes one patient's condition and does not provide general research results or a large study.
Renal Oncocytomatosis and Oncocytosis: A Patient-Level Systematic Review of 95 Reported Patients
This review gathered data from 95 patients with a very rare kidney condition. It summarizes how the disease looks, how it is treated, and what happens to patients. It is a review...
Polycystic kidney disease in pregnancy: A retrospective study on obstetric and neonatal outcomes
This preprint looks at pregnancy outcomes for people with polycystic kidney disease. It is not yet peer-reviewed, and no abstract is available to describe the specific findings.
A case report of nephronophthisis type 1 (NPHP1) complicated with tethered cord in a pediatric patient: clinical phenotype and rapid progression to end stage renal disease
This is a single case report about a child with a rare genetic kidney disease. It describes how the child's condition progressed quickly. It is one person's experience, not a large...
Case Report: Laser thermal ablation for severe primary hyperparathyroidism in a pregnant patient with MEN1 syndrome
This is a single case report about a pregnant woman with a rare hormone disorder. It describes a laser procedure used to treat her condition. It is one person's experience, not a...
https://www.theisn.org/news/insight-oct-12-2026/
This is a newsletter from a kidney health group. It shares general news and updates. There are no new study results in this item.
https://www.theisn.org/blog/2026/10/12/isn-members-put-your-expertise-in-service-of-global-kidney-health-apply-to-an-isn-committee-or-working-group/
This post asks members of a kidney society to join a working group. It is a call for volunteers. There are no study results here.
https://www.theisn.org/blog/2026/10/12/gain-global-recognition-through-fellow-of-the-isn-status/
This post explains how to get a special title from a kidney society. It is about professional recognition. There are no study results here.