Kidney research, 2026-10-02
New data shows Nefecon beats steroids for a common kidney disease.
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A real-world study found that Nefecon works better than steroids for a common kidney condition.
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Other reports today were limited to single patients, animal trials, or small biopsy reviews.
The main news today is a positive finding for a specific drug used in kidney disease. The rest of the reports are smaller studies or animal tests that do not change daily care yet. This gives a clearer picture of treatment options for one specific condition.
Impact of CYP3A5 genotype on tacrolimus pharmacokinetics and clinical outcomes in pediatric patients with Henoch-Schönlein purpura nephritis.
This study checked how a specific gene affects how children process a drug called tacrolimus. It looked at children with a kidney condition called Henoch-Schönlein purpura...
Resistant Hypertension: State of the Art Review.
This review explains how to handle blood pressure that is hard to control with standard drugs. It notes that over 140 million people have this condition. It is a summary of current...
Management of type 2 diabetes, 2026. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).
Major medical groups released an updated guide on how to care for people with type 2 diabetes. It covers lifestyle changes and how to manage related health risks. This is a set of...
Efficacy and mechanistic insights of dapagliflozin in hypertension management.
This is a narrative review that discusses how a specific diabetes drug called dapagliflozin affects blood pressure. It explains the biological reasons for these effects. It is a...
Renoprotective effects and safety of sodium-glucose cotransporter 2 inhibitors in diabetic chronic kidney disease: A systematic review and meta-analysis.
This large review combined data from many trials to check a class of diabetes drugs called SGLT2 inhibitors. It found these drugs are safe and help protect the kidneys in people...
Combination Therapy of Romiplostim and Erythropoiesis-stimulating Agents
This trial is starting to test a drug called romiplostim for people on dialysis. It will check if adding this drug to standard anemia treatment is safe. There are no results yet....
Effects of semaglutide on kidney disease in type 2 diabetes: a randomized placebo-controlled trial.
People with type 2 diabetes and kidney disease who took semaglutide kept their kidney function better than those on a placebo. The study was small: 106 people, and the effect was...
Mapping the complement-targeted landscape in igA nephropathy: a systematic review with structured descriptive synthesis
This review looks at new drugs that target the immune system in IgA nephropathy. It includes data from large phase III trials. It summarizes what is known about these treatments...
Differences in urinary biomarker profiles in patients with nephrotic-range proteinuria with and without hypoalbuminemia: a single-center cross-sectional study
This study compared urine markers in people with heavy protein in the urine. It is an observational study, so it shows a link, not proof of cause. It helps doctors understand...
Next Generation Sequencing and Genome-Wide Association Studies to Identify Mitochondrial Genomic Features Associated with Diabetic Kidney Disease
This study looked at genes linked to kidney disease in people with diabetes. It is an observational study, so it shows a link, not proof of cause. It helps researchers understand...
Identification and evaluation of novel biomarkers in diabetic kidney disease
This study is looking for new blood tests to catch kidney damage early. It focuses on people with diabetes. There are no results yet.
Pressure-Strain Loop-Derived Myocardial Work in Hemodialysis versus Peritoneal Dialysis: A Cross-Sectional Echocardiographic Study.
This study compared heart function in 136 people on dialysis. It looked at 70 on machine dialysis and 66 on peritoneal dialysis. The scan showed differences in how hard the heart...
Elranatamab in relapsed/refractory multiple myeloma patients on hemodialysis: A real-world case series.
This report looks at four people on dialysis who took a new cancer drug. It is a case series, which is a small group of real-world patients. There are no results yet from a large...
The bile acid chenodeoxycholic acid attenuates renal fibrosis in mouse precision-cut kidney slices
A natural bile acid helped reduce scarring in mouse kidney tissue. This was a lab study, not in people yet. It shows a possible path for future drugs.
Structural basis of calcium-sensing receptor activation by extracellular modulators
This study used high-resolution imaging to see how a drug binds to a protein. It helps explain how the drug works. This was a lab study, not in people yet.
COMPARISON OF TREATMENT METHODS FOR URETEROPELVIC JUNCTION OBSTRUCTION AND DRAINAGE METHODS IN CHILDREN
This study compared different surgery options for a blockage in the kidney tube of children. It also looked at how the urine was drained after the surgery. The research was a...
PRDX1 as a Redox Gatekeeper at Mitochondrial-ER Contact Sites: Implications for Kidney Fibrosis Progression and Therapy
This paper proposes a model for how a protein controls cell stress. It links this to kidney scarring. This was a lab study, not in people yet.
Heterogeneity and Intercellular Coupling Prevent Sinus Arrest in Rabbit Sinoatrial Node Model
This study used a computer model of a rabbit heart. It looks at how low calcium affects heart rhythm. This was a lab study, not in people yet.
Soluble guanylate cyclase modulation in heart failure and chronic kidney disease: mechanisms, clinical evidence, and translational boundaries
This review looks at how a specific drug target works in people with heart and kidney disease. It explains the biology behind these conditions and how they affect each other. The...
Risk Prediction of Incident Chronic Kidney Disease Using Plasma Proteomics in Individuals Without Diabetes
This study looked at blood proteins to see if they can predict who will develop kidney disease. It focused on people who do not have diabetes. The results show a link between these...
Kidney stone and cyst occurrence and renal function in the solitary kidney after radical nephrectomy for renal cell carcinoma: a retrospective controlled study
This study checked how well the remaining kidney works after one is removed for cancer. It looked at 72 patients and 50 healthy controls. The researchers measured kidney function...
Identification of Gut Microbiome Signatures Associated with the Kynurenine Pathway in Tryptophan Metabolism in Patients Undergoing Hemodialysis
This study looked at gut bacteria in 85 people on dialysis. It checked how these bacteria affect the body's handling of tryptophan, an amino acid. The results show a link between...
Association of SGLT2 inhibitors and GLP-1 receptor agonists with mortality and renal outcomes in patients with diabetes and chronic kidney disease: the diabetic nephropathy management and outcome (DINAMO) study
This large study looked at real-world data from Israel. It found that people with diabetes and kidney disease who took SGLT2 inhibitors or GLP-1 drugs had lower rates of death and...
Initial side effects of roxadustat on thyroid function in patients undergoing hemodialysis
This study checked if roxadustat, a drug for kidney anemia, affects the thyroid. It looked at patients on dialysis who started taking the drug. The results show a link between the...
Diffusion tensor MR neurography reveals altered sciatic and tibial nerve microstructure in chronic dialysis patients
This study used special MRI scans to look at nerves in 30 people on dialysis. It compared them to 30 healthy controls. The scans showed changes in the structure of the nerves in...
Low Muscle Quality Predicts Creatinine-Based eGFR Overestimation Better than Skeletal Muscle Mass in Patients with Chronic Kidney Disease
This study looked at 86 adults with kidney disease who were not on dialysis. It found that low muscle quality is a better sign of inaccurate kidney function tests than just low...
Mechanisms of anemia in patients with chronic kidney disease and involvement of cardiorenal anemia syndrome
This study explains why people with kidney disease often have low red blood cell counts. It looks at how the kidneys and heart work together in this process. The results show a...
Machine learning-based predictive model for pulmonary hypertension risk stratification in chronic kidney disease: development, internal validation and temporal external validation
This study built a computer model to predict high blood pressure in the lungs. It used data from 393 people with kidney disease. The model helps doctors decide who needs a heart...
Inverse correlation between plasma 3-chlorotyrosine and pinch strength in chronic kidney disease patients.
This study looked at 292 people with chronic kidney disease. It found a link between a blood marker of inflammation and low muscle strength. Higher levels of the marker were tied...
Frequency and Severity of Cognitive Impairment Across Stages of Chronic Kidney Disease: A Cross-Sectional Study from A Tertiary Nephrology Centre in Rajasthan, India
This study checked the thinking skills of 138 adults with kidney disease. It found that cognitive issues were common across all stages. The problems got worse as the disease...
Gut Microbiota–Host Redox Crosstalk: Molecular Mechanisms, Disease Pathogenesis, and Therapeutic Interventions
This review explains how gut bacteria affect the body's balance of stress and repair. It covers how this link plays a role in kidney disease. It discusses possible treatments based...
Recent progress in the biomarkers of peripheral artery disease
This article covers new blood tests for artery disease. It does not have an abstract to review. There are no specific results to report from this item.
GLP-1 Receptor Agonists and Risk of Kidney Replacement Therapy and Health Care Utilization in Bipolar Disorder With Chronic Kidney Disease
This study looks at a diabetes drug and kidney outcomes. It focuses on people with bipolar disorder. It does not have an abstract to review. There are no specific results to report...
Albuminuria is Associated with Higher Turnover-Related Bone Histomorphometric Indices in Chronic Kidney Disease Stages 3–4
This study checked bone samples from 56 adults with kidney disease. It found a link between protein in the urine and faster bone changes. This shows a connection, not proof of...
https://www.era-online.org/publications/obesity-and-chronic-kidney-disease-a-cardio-kidney-metabolic-framework-for-renal-vulnerability-and-risk-stratification/
The page for this article could not be opened because of a security check. We do not have the text or any results to review yet.
Engineered naringenin-loaded nanoscale coordination polymers for targeted treatment of acute kidney injury.
Scientists created tiny particles that carry a natural plant compound to treat sudden kidney damage. The goal is to help the drug reach the kidney more effectively. This research...
Mentha-mediated selenium nanoparticles attenuate adriamycin-induced chronic kidney disease via multi-target modulation of oxidative, inflammatory, and fibrotic pathways.
Researchers tested a new type of tiny particle made from mint and selenium in rats. The particles helped reduce kidney damage caused by a specific drug in the animals. This is an...
Predictors of Antibody Response to Hepatitis B Vaccination in Hemodialysis Patients.
People on dialysis often do not build enough protection from hepatitis B vaccines. This study checked 50 patients in Bangladesh to see who responded well. It is an observational...
Trends in Iron Indices among Non-Dialysis Chronic Kidney Disease Patients with Anemia.
This study checked iron levels in 50 people with kidney disease and low blood counts. It looked at patients who are not yet on dialysis in Bangladesh. This is an observational...
Elevated asymmetric dimethylarginine drives hematopoietic stem cell metabolic reprogramming and dysfunction in chronic kidney disease.
This study found that a protein called ADMA builds up in people with kidney disease. In mice, this buildup harmed the stem cells that make blood. This was done in animals, not...
FGF-23 is associated with increased risk of abdominal aortic calcification: A Mendelian randomization study with phosphate as a potential mediator.
This study used genetics to look at a link between a hormone and hardening of the abdominal aorta. It suggests that a substance called phosphate may be the cause of this link. This...
Safety of a Healthy Plant-based Diet With Higher Potassium Content, Compared to a Healthy Plant-based Diet With Limited Potassium Content in Patients With Chronic Kidney Disease: A Pilot Study
This pilot study is starting to test a plant-based diet with more potassium. It will compare this to a diet with less potassium for people with kidney disease. There are no results...
Ten tips to reduce fracture risk by non-pharmacologic interventions in CKD-associated osteoporosis.
This review offers practical advice on how to keep bones strong when you have kidney disease. It focuses on lifestyle changes rather than just medicine. The article summarizes...
Disasters and hazard exposure in end-stage kidney disease: a scoping review of patient outcomes.
This review looks at how natural disasters and other hazards affect people with end-stage kidney disease. It gathers information from 30 studies to understand the risks. It is a...
Development and feasibility of an arts-based intervention for patients with end-stage kidney disease whilst receiving haemodialysis
This study is planning a new art program for people on dialysis. The goal is to help with mental health and quality of life. There are no results yet.
Literature Review: Analysis of Spiritual Well-Being and Quality of Life in Patients with Chronic Kidney Disease Undergoing Hemodialysis
This review looked at 8 studies on people on dialysis. It found that spiritual well-being is linked to better quality of life. It helps patients find meaning and hope. This is a...
Frailty: why does it matter in kidney transplantation?
This paper discusses how to spot frailty in transplant candidates. It aims to help doctors pick the right patients. There are no results yet.
Spatial transcriptomic profiling of porcine tissue microarray detecting subclinical circovirus infection.
Researchers developed a new way to detect a virus in pig tissue. This is important for using pig organs in human transplants, as the virus can hide in the tissue. This work was...
https://www.kidney.org/news-stories/new-standard-kidney-function-estimation-what-healthcare-professionals-need-to-know
This is a news page from the National Kidney Foundation. It discusses new ways to estimate kidney function. There are no study results here. It is an informational article for...
Sex-specific clinical profiles in patients with acute ischemic stroke and chronic kidney disease
This study looked at how stroke and kidney disease affect men and women differently. It is an observational study, so it shows a link, not proof of cause. It helps doctors...
Outcome-specific value of longitudinal clinical information and model complexity for dynamic prediction of type 2 diabetes-related outcomes: a pooled landmarking study
This study tested computer models to predict diabetes complications, including kidney disease. It is an observational study, so it shows a link, not proof of cause. It helps...
Manajemen Penyakit Ginjal Kronis Stage V pada Wanita Usia 72 Tahun: Sebuah Laporan Kasus
This is a case report about one 72-year-old woman with stage 5 kidney disease. It describes her hospital stay and treatment. It is a single person's experience, not a large study.
Economic studies of chronic kidney disease
This paper looks at the cost of kidney disease to society. It notes that dialysis uses a large share of health budgets. There are no new results in this document.
Optimisation of biopsy practice to facilitate timely diagnosis and management of kidney disease
This study is reviewing how kidney biopsies are done. It aims to make the process safer and faster. There are no results yet.
Fatigue and self-management strategies among patients with end-stage kidney disease (ESKD) receiving haemodialysis: a prospective qualitative exploration conducted in the Sultanate of Oman
This study is exploring how people in Oman manage fatigue on dialysis. It aims to find better self-care tips. There are no results yet.
Explainable Machine Learning for Chronic Kidney Disease (CKD) Detection
This project is building a computer tool to spot kidney disease. It uses routine data instead of lab tests. There are no results yet.
Informing the development of an intervention to support informal caregivers of patients with end stage kidney disease (ESKD) receiving haemodialysis (EVOLVE Study)
This study is planning a support program for family caregivers. It aims to help them manage the stress of dialysis. There are no results yet.
Dental Students’ Self-Reported Preparedness for Managing Patients with Chronic Kidney Disease and Kidney Transplants: Academic-Year Comparisons and Cluster-Based Educational Profiles
This survey asked dental students if they feel ready to treat kidney patients. It is a cross-sectional study, which shows a link, not proof of cause. It helps plan student...
Comments on “Chronic kidney disease due to hypertension in China, Japan, and the Republic of Korea: trends from the global burden of disease study 1990–2023”
This is a comment on a study about kidney disease in Asia. It does not have an abstract to review. There are no new results to report from this item.
https://www.theisn.org/blog/event/isn-ason-webinar-management-of-anemia-in-cancer-patients-and-vegf-inhibitors-related-kidney-adverse-events/
This is a page for a webinar on kidney issues in cancer patients. It covers how to manage low blood counts. There are no new results from a study in this item.
https://www.theisn.org/blog/event/isn-roundtable-research-peer-review-and-publication-in-nephrology/
This is a page for a roundtable on publishing research. It discusses how studies are reviewed. There are no new results from a study in this item.
Kidney Week 2026 Abstracts Now Available
The main kidney research meeting has released its list of papers for this year. This page allows you to browse the topics that will be discussed. There are no new results here,...