← brief for 2026-10-02 · Slowing decline

Elevated asymmetric dimethylarginine drives hematopoietic stem cell metabolic reprogramming and dysfunction in chronic kidney disease.

Article D Peer reviewed Preclinical

Key takeaways

This study found that a protein called ADMA builds up in people with kidney disease. In mice, this buildup harmed the stem cells that make blood. This was done in animals, not people yet. It helps explain why blood counts change in kidney disease.

Who did this work

Chen Z · Zhong X · Yao M · Liu Y · Chen J · Lan Q · Lu Y · Chen F · Chen M · Xu Y · Xu Z · Wang J

Source

Article · PubMed, CKD progression and prevention · 2026 Oct 2
https://pubmed.ncbi.nlm.nih.gov/42826876/