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Impact of CYP3A5 genotype on tacrolimus pharmacokinetics and clinical outcomes in pediatric patients with Henoch-Schönlein purpura nephritis.

Key takeaways

This study checked how a specific gene affects how children process a drug called tacrolimus. It looked at children with a kidney condition called Henoch-Schönlein purpura nephritis. The results show a link between the gene and drug levels in the blood. This is an observational study, so it does not prove the gene causes the effect.

Who did this work

Li H (Department of Pharmacy, Kunming Children's Hospital.) · Li N (Department of Pharmacy,Yunnan Provincial Hospital of Infectious Disease.) · Tang X (Department of Orthopedics, Kunming First People's Hospital, Kunming, China.) · Li F (Department of Pharmacy, Kunming Children's Hospital.) · Ren D (Department of Pharmacy, Kunming Children's Hospital.) · Zong J (Department of Pharmacy, Kunming Children's Hospital.) · Tu C (Department of Pharmacy, Kunming Children's Hospital.) · Li L (Department of Pharmacy, Kunming Children's Hospital.) · Zhang L (Department of Pharmacy, Kunming Children's Hospital.) · Yu S (Department of Pharmacy, Kunming Children's Hospital.)

Source

Article · Europe PMC, CKD · 2026-09-29
https://doi.org/10.1097/fpc.0000000000000604