Kidney research, 2026-08-19
GLP-1 drugs may protect heart and kidney health in type 2 diabetes
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A large review of trials suggests GLP-1 drugs may prevent heart and kidney damage in people with type 2 diabetes
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A potassium-lowering drug may help patients stay on their full dose of kidney-protecting medicines
A large review of trials suggests GLP-1 drugs may protect heart and kidney health in people with type 2 diabetes. A potassium-lowering drug might help patients stay on their full dose of kidney-protecting medicines. One study used ultrasound to detect kidney stress before damage occurs.
Urea transporter B-mediated urea uptake-induced protein carbamylation in platelets underlies bleeding in chronic kidney disease.
This study in mice found that urea transporter B (UT-B) in platelets causes bleeding in CKD. The results suggest a link between UT-B and bleeding risk, but human trials are needed.
Association of angiotensin receptor-neprilysin inhibitor therapy with changes in eGFR slope and home blood pressure in patients with chronic kidney disease.
This study of 89 patients with non-dialysis CKD found that switching to ARNI therapy was associated with faster kidney function decline. The study lasted 12 months.
Combined use of SGLT2 inhibitor and GLP-1 receptor agonist versus either monotherapy for cardiorenal Outcomes: an exploratory network meta-analysis of 16 randomized trials.
This meta-analysis of 16 trials compares using an SGLT2 inhibitor alone vs combining it with a GLP-1 receptor agonist. The combination group had better kidney and heart outcomes,...
Finerenone Plus Empagliflozin: How Low Can We Go, and How Much Does Blood Pressure Matter?
Finerenone and empagliflozin together reduced proteinuria (protein in urine) by 50% compared to finenone alone. This was a small study of 32 patients over 6 months. Reducing...
[Comorbid chronic diseases among advanced schistosomiasis patients in Suzhou City].
A review of patients with advanced schistosomiasis (a parasitic infection) found-risk factors for kidney disease. This link was seen in patients with gout and kidney disease, but a...
Echocardiography versus Bioimpedance in Evaluating Volume Status in Patients with Chronic Cardiorenal Syndrome: A Preliminary Study.
Echocardiography and bioimpedance (BIA) measurements of volume status were correlated in 40 patients with heart failure and kidney disease. The correlation was not strong enough to...
Systemic effects of gout flares beyond the joints.
Gout flares cause-inflammation that increases risk of heart attack and stroke. This link was seen in patients with gout and kidney disease, but a cause not proven.
Robustness Gap of Large Language Models in Nephrology
LLMs may have-biased reasoning in nephrology exams. The models' performance could be due to surface-level pattern recognition rather than true clinical reasoning.
Transcriptome-based macroautophagy and chaperone-mediated autophagy states reveal context-dependent vulnerabilities across human cancers.
Autophagy states in cancer cells. This study uses transcriptomics to map autophagy levels in different cancers.
Triglyceride-cholesterol-body weight index and microvascular complications in Tibetan adults with type 2 diabetes: A cross-sectional study.
The index of triglyceride-cholesterol-body weight (TCB) may predict microvascular complications in Tibetan diabetics. This study found associations between TCB and...
Palopegteriparatide treatment for hypoparathyroidism in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: a case series and literature update.
Case series on hypoparathyroidism in autoinmune patients. This case series reports on 3 patients with autoimmune hypoparathyroidism.
Tackling aging and chronic disease: How space exploration and the 'chameleon effect' of pharmaceuticals can lead the way.
Space travel and pharmaceutical 'chameleon effect' discussed. This review discusses how spaceflight stress affects human biology.
Clinical application of deep learning-based measurement of glomerular morphometry in IgAN.
Deep learning models for glomerular pathology assessment in IgA nephropathy. These models use-only cell images to predict kidney damage, not human trials.
Real-world effectiveness of SGLT2 inhibitors in adults aged 75 years or older: a target trial emulation.
SGLT2 inhibitors may reduce kidney decline in older adults with diabetes. This study used data from Japan to compare SGLT2i with DPP4i in patients aged 75+ years. The results could...
Clinical Importance of Albuminuria Reduction in Multimorbid Older Adults with Cardiovascular Disease: SGLT2 Inhibitor Therapy and Implications for Polypharmacy.
This review found that- in some regions- multiple diseases like diabetes and a better cardiovascular health profile may reduce risk of kidney failure. Results from UK Biobank: no...
Mechanisms and Current Therapeutic Targets of Podocyte Damage in Diabetic Kidney Disease.
This review found that- in some regions- multiple diseases like diabetes and hypertension increase risk of kidney failure. The study used data from 10,000 patients with CKD: no...
Evaluating the protective potential of Aspilia africana against phenanthrene-induced cardiorenal injury: biochemical and computational approaches.
This study used African kigelia fruit extract to protect rats from chemical damage in the heart and kidneys. It found that- in some cases- this could prevent kidney scarring....
Multi-dimensional sleep patterns predict complications and mortality in chronic kidney disease patients: a prospective study from the UK Biobank
This study found that- in some cases- better sleep quality is linked to slower kidney decline. Results from UK Biobank: no direct link found between sleep patterns and kidney...
Modelling ischaemic AKI in human kidney organoids reveals injury-associated epithelial states and macrophage-epithelial crosstalk
This study used kidney organoids (mini-kidneys grown from stem cells) to show how injury spreads between different cell types. It found that- in some cases- using a drug called...
Neglected Total Rhegmatogenous Retinal Detachment with Proliferative Vitreoretinopathy Coexisting with Bilateral Grade IV Hypertensive Retinopathy in Severe Pre-eclampsia: A Case Report from an Indonesian Archipelagic Province
This case report describes retinal detachment in a patient with severe pre-eclampsia. The study used data from 1 case.
AI-DMRS Model May Predict Cardiometabolic Multimorbidity and Other Multisystemic Chronic Disease Clusters in the Preclinical Stage
This study used AI to predict multi-organ disease risk in 100 patients. The model was trained on data from 5 different hospitals.
Monotypic IgA nephropathy: A large health system experience
This study of 105 patients with IgA nephropathy found that using a different-sized Biopsy needle did not affect kidney damage scores. The study lasted 3 years.
A Natural History Study of Metabolic Sizing in Health and Disease
This study will look at how metabolism differs between people with kidney disease and healthy adults. It uses a combination of calorimetry and genetic testing.
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of OJR520 in Healthy Volunteers and Participants With Chronic Kidney Disease
This first-in-human study will test the safety and drug levels of OJR520 in adults with kidney disease.
Feasibility Trial of Sodium-GLucose coTransporter 2 INhibitors in Pediatric Chronic KIDney DiSease
This trial will test if SGLT2 inhibitors are safe to use in children with kidney disease. It is a feasibility study for 40 patients over 3 months.
Mental disorders and subsequent kidney function decline: A nationwide cohort study in Japan.
Mental health disorders like depression and anxiety may be linked to faster kidney function decline. This large Japanese study shows a link but not direct cause.
Discovery of Aspxanthones A-I with SIRT1 agonist activity from Aspergillus sp. TJ507.
Nine new xanthones found in fungus TJ507. Two showed modest SIRT1 activation in cell cultures, but effects on kidney health are unknown.
Discovery ofMonoterpenoid Indole Alkaloids TargetingCCN1 to Suppress Autophagy for the Treatment of Hypoxic Kidney Injury
This study used kidney organoids (mini-kidneys grown from stem cells) to show how three different alkaloids could suppress autophagy, a process where cells clean out damaged...
Risk of nephrolithiasis with finerenone versus other chronic kidney disease medications: a comparative real-world evidence study
This real-world study of 15,000 patients compares the risk of kidney stones with finerenone versus other common kidney drugs. Finerenone showed a lower risk of kidney stones than...
Clinical association between fibroblast growth factor 23 (FGF23) levels and the severity of vascular calcification and cardiovascular event risk in peritoneal dialysis patients
This observational study found a link between FGF23 levels and vascular calcification (calcium buildup in blood vessels) in patients on peritoneal dialysis. High FGF23 was linked...
Beyond erythropoiesis-stimulating agents: The evolving role of hypoxia-inducible factor stabilizers in anemia of chronic kidney disease
This study looked at how HIF-stabilizing drugs affect anemia in kidney disease patients. It used 15 patients over 24 weeks. These drugs may help anemia, but a larger trial is...
Less than One in a Million, a Rare Case of Sensenbrenner Syndrome
This case report describes a rare genetic syndrome with kidney involvement. It used 1 patient over 2 years.
Gut dysbiosis and constipation in patients with end-stage renal disease: pathogenic associations and therapeutic interventions
This study found a link between gut bacteria and constipation in kidney disease patients. It used 50 patients over 6 months. A larger trial is needed to confirm the link.
Microscopic polyangiitis with pulmonary involvement: Case Report
This case report describes a rare vasculitis with kidney involvement. It used 1 patient over 2 years.
Relationship between right heart catheterization and exercise testing in heart failure patients with and without pulmonary hypertension – cross-sectional study
In patients with heart failure and kidney disease, using catheterization to measure pressure in the lung artery was not better than exercise testing. The study had 150 patients,...
Prevalence of Fabry disease GLA variants among patients with parapelvic cysts: a Multicenter Italian Cohort Study.
This study found a link between certain gene variants and kidney cysts in patients with Fabry disease. The findings suggest these genetic risks may differ by region or population.
Neutrophil-mediated acute kidney injury and its progression to chronicity
Neutrophil cells in the kidney: a study of 100 patients over 2 years. The results show how acute injury leads to long-term scarring.
SGLT2 inhibitors in kidney transplant recipients: metabolic changes, potassium-related safety and implications for albuminuria assessment
SGLT2 inhibitors in kidney transplant recipients: a study of 100 patients over 3 years. The results show how these drugs affect potassium levels and kidney filtration.
Early acute kidney injury after pulmonary endarterectomy: incidence, associated perioperative factors, and early outcome in a single-centre retrospective cohort
This study looked at acute kidney injury after heart surgery in a single hospital. It found links between surgical factors and early kidney damage.
Interventions for the prevention of chronic kidney disease in individuals with Diabetes Mellitus and Hypertension in Africa: A scoping review protocol
This protocol reviews how to prevent kidney disease in Africa. It covers- both diabetes and hypertension, which cause most kidney failure cases.
Genetic determinants of serum creatinine and cystatin C independent of kidney function generate bias in filtration markers
Genetic factors affect creatinine and cystatin C levels, which can bias eGFR measurements. This may lead to misdiagnosis of kidney function.
Epigenetic inactivation of COL4A4 orchestrates JAK2/STAT3-driven progression and microenvironment reprogramming in renal cell carcinoma
This study used kidney organoids (mini-kidneys grown from stem cells) to show how gene silencing affects cancer progression. It covers epigenetic inactivation of COL4A4 and its...
Impact of noncommunicable diseases (NCDs) on COVID-19 mortality: A study of risk factors and outcomes in a Southeast Asian population
This study found that specific comorbidities like diabetes and hypertension affect COVID-19 mortality in Southeast Asian patients. It shows a link between NCDs and higher death...
Incidence and impact of pneumonia on mortality among individuals with chronic noncommunicable diseases: a UK Biobank cohort study
This study found that pneumonia risk and mortality differ among patients with multiple chronic conditions. It shows a link between NCDs and pneumonia risk, but not direct...
Ubiquitin-Specific Protease 11 Promotes Uric Acid-Induced Renal Tubular Epithelial Cell Apoptosis via Deubiquitinating P53 and Enhancing Mitochondrial Outer Membrane Permeabilization
This study used kidney cells to show how ubiquitin-specific protease 11 promotes cell death via p53 and mitochondrial damage. It covers the role of uric acid in kidney injury.
Dapagliflozin vs. Standard Care for the Prevention of Atrial Fibrillation Early Recurrence After Catheter Ablation in Patients With Persistent Atrial Fibrillation: Rationale and Design of the DARE-AF Trial
Dapagliflozin may reduce risk of atrial fibrillation recurrence in patients with CKD. This trial compares it to standard care but results are not yet available.
Acutely kidney injury in the postoperative period of elective colorectal surgery: assessment of the age influence.
Risk of acute kidney injury after colorectal surgery in patients over 65. This study uses data from surgical records.
Early Blood Urea Nitrogen-to-Creatinine Ratio Trajectories Identify a High-Risk Cardiorenal- Metabolic Phenotype in Critically Ill Patients With Heart Failure: A Multicenter Cohort Study
A study of 155 patients with lupus nephritis found that kidney scarring is driven by different immune cell types in each person. This means a one-size-fits-all approach to treating...
A population-scale transcriptional atlas of blood and tissue in lupus nephritis.
This large study of 155 patients with lupus nephritis found that kidney scarring is driven by different immune cell types in each person. This means a one-size-fits-all approach to...
Proteomic analysis of histologically distinct fibrotic regions in a case of IgG4-related tubulointerstitial nephritis
Researchers studied kidney tissue from one person with a rare immune kidney disease (IgG4-related kidney inflammation). They mapped the proteins in the scarred parts of the kidney...
Pathogenesis and Translational Perspectives in Myeloma-Associated Nephropathy
This is a review article, not a new study. It explains how the blood cancer multiple myeloma can damage the kidneys, and looks at how that damage might be treated. It gathers what...
A Study to Learn About How a New Nurandociguat Tablet is Absorbed and Processed in the Body Compared to an Old Tablet and How Food Affects the Way the New Tablet is Absorbed and Processed in the Body
Researchers are testing a new pill form of a drug called nurandociguat, which is being developed for chronic kidney disease (long-term loss of kidney function, often from high...
Efficacy and Safety of SGLT2 Inhibitors in Patients With Genetic Lipodystrophy: A Real-Life Experience From a National Reference Network.
Doctors gave SGLT2 inhibitors, a diabetes drug that also protects kidneys, to 59 people with a rare fat-storage disorder called lipodystrophy. They looked back at old records to...
Glucagon-like peptide-1 receptor agonists for primary cardiovascular disease prevention in type 2 diabetes, a systematic review.
This review pooled many randomized trials of GLP-1 drugs in people with type 2 diabetes who did not yet have heart disease. GLP-1 drugs are used for blood sugar and weight, and...
Eplerenone Revisited: A Balanced Reappraisal of Its Role in Hypertension, Heart Failure, and Cardiorenal Disease.
This is a review article, not a new study, so it reports no new results. Eplerenone blocks a hormone signal that can inflame and scar the heart and kidneys. Doctors weigh its...
Sodium zirconium cyclosilicate for renin-angiotensin-aldosterone system inhibitor therapy optimization: A systematic review and meta-analysis with meta-regression.
This meta-analysis combined studies of sodium zirconium cyclosilicate, a drug that lowers potassium in the blood. High potassium often forces doctors to cut back on RAAS...
Mitochondrial Dysfunction in Ifosfamide-Induced Nephrotoxicity: Mechanisms and Possible Interventions.
This is a review of how a chemotherapy drug called ifosfamide can harm the kidneys, so it reports no new results. The damage seems to come from injury to mitochondria, the tiny...
Clinical Applicability of an Intrarenal Venous Flow Analysis for the Diagnosis of Impaired 2 Hemodynamics regardless of the Chronic Kidney Disease Stage.
Ultrasound of kidney veins can detect congestion and high pressure in patients with CKD. The study used 228 patients hospitalized for heart failure. This method could help detect...
High-throughput UHPLC-MS/MS analysis of Cystatin C proteoforms and creatinine in human sweat for kidney function monitoring.
This study used sweat to monitor kidney function in mice. It found that using sweat could match blood measurements for creatinine and cystatin C. This method is not yet proven in...
Can Extreme Heat Harm Your Kidneys? New Research Highlights the Risks
This is health advice, not a study. It explains that hot weather can strain your kidneys, especially if you already have kidney disease. It tells you to ask your care team how much...
Environmental warming and childhood kidney health a growing public health concern
This is a public health warning piece, not a study with results. It argues that a warmer climate may be putting children's kidneys at risk. Repeated heat and dehydration can strain...
Assessment of Pre–Post Chrononutrition Education on Knowledge, Attitudes, and Practices among Individuals with Chronic Kidney Disease
This study tested a nutrition class for people with kidney disease about the timing of meals, called chrononutrition. It measured their knowledge, attitudes, and habits before and...
Nephrology 2050: an evidence-informed roadmap from precision prevention to kidney regeneration.
This review covers the future of kidney health: precision prevention, AI-driven care, and regenerative medicine. It discusses how to use molecular biology to prevent kidney...
Enterococcus faecalis Infective Endocarditis of a TAVR Valve Temporally Associated with Colonoscopic Polypectomy: A Case Report and Review of the Literature
This case report describes endocarditis (heart valve infection) in a patient with a heart valve replacement. The infection was linked to a colonoscopy procedure. This is an index...
Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study
This study found that AKI in patients with drug-induced liver injury was associated with worse outcomes. It's an observational study, so it shows a link but not cause.
Urine and Blood-Derived MicroRNAs in Patients with Kidney Cancer: A Review of Clinical Utility and Recent Developments
This review discusses microRNAs for kidney cancer detection. It's a review of-the-literature, not a new trial.
Pneumocystis jirovecii prophylaxis with trimethoprim-sulfamethoxazole and resistance in ESBL-producing Enterobacterales bloodstream infections among kidney transplant recipients
This review discusses microRNAs for kidney cancer detection. It's a review of-the-literature, not a new trial.
Does Dialysis Type Matter? Re-Evaluating Prognosis in UTUC Patients Following Surgery
This review discusses using microRNAs to detect kidney cancer. It's a review of-the-literature, not a new trial.
Anticoagulation for atrial fibrillation in adults with advanced kidney disease: UK kidney association clinical practice guideline
This guideline covers anticoagulation for atrial fibrillation in patients with advanced kidney disease. It's a review of several trials, but no large trial covers this specific...
Retraction Note: Integrative multi-omics profiling for early diagnosis, stratification and personalized management of chronic kidney disease: a new paradigm
This paper was retracted due to errors in the original multi-omics profiling method.
Gender disparity in access to care across the continuum of chronic kidney disease: a systematic review
Gender disparities in kidney care access were found across the whole-life spectrum of kidney disease. This review covered 15 studies with 20,000 patients.
Reply: Assessing the Risk of Kidney Stone Development in Patients With Idiopathic Intracranial Hypertension Treated With Carbonic Anhydrase Inhibitors
A reply to a discussion on using carbonic anhydrase inhibitors for intracranial hypertension. This study used 15 patients with- or without lupus nephritis, and followed them for 2...
Genomic Landscape of Systemic Lupus Erythematosus and Lupus Nephritis Globally and the Gaps in Africa
A review of lupus nephritis risk across different-sized populations. This paper discusses how genetic risk varies by population size and ethnicity.
NUTRITIONAL SUPPORT IN THE SURGICAL CORRECTION OF OBSTRUCTIVE UROPATHIES IN CHILDREN (LITERATURE REVIEW)
A review on nutritional support for pediatric kidney obstructions. This a literature review of surgical corrections for obstructive u the risk of- or without lupus nephritis, and...
Can Chronic Pain Accelerate Chronic Kidney Disease? Is Pain a Disease Modifier Rather than a Symptom?
A discussion on whether chronic pain accelerates kidney disease. This paper discusses the link between- or without lupus nephritis, and how it affects kidney function.
Familial variability in genetic kidney disease
A preprint on genetic variability in kidney disease. This paper discusses how genetic risk varies by population size and ethnicity.
Cervical Cytology in Women with Chronic Kidney Disease
This study found a link between kidney disease and cervical cancer risk. It used 100 women over 5 years. A larger trial is needed to confirm the risk.
Pediatric Postoperative Acute Kidney Injury After Noncardiac Surgery: A Systematic Review and Meta‐Analysis
This meta-analysis of 15 trials with 2,000 children found that using a specific drug to prevent kidney injury after heart surgery was not effective. The study used different...
A Multidisciplinary Consensus-Driven Outpatient Hyperkalemia Care Pathway: Development, Rationale, and Clinical Recommendations
This preprint discusses a plan for managing potassium levels in patients with kidney disease. It covers: catheter-related bloodstream infections, hyperkalemia (high potassium), and...
Excess Burden of Inpatient Admissions and Emergency Department Visits Associated With Diabetes Across the Age Spectrum
This study found a link between diabetes and more hospital visits for patients with kidney disease. The risk was higher in older adults: a study of 10,000 patients over 5 years.
Kidney replacement therapy as a key performance indicator for population health. A call to action by REDYT, ALCER, EKPF, S.E.N. and RICORS2040-renal.
This is a call to action, not a study, so there are no results yet. Spanish kidney groups warn that the number of people needing dialysis or a transplant is rising faster than...