Kidney research, 2026-10-19

Incidence and Progression of Acute Kidney Injury Following Head and Neck Surgeries for COVID-19-Associated Mucormycosis: A Prospective Observational Study

Evaluation of the Berden Classification and ANCA Kidney Risk Score in Biopsy-Proven ANCA-Associated Glomerulonephritis: Associations with Clinical Characteristics and Outcomes.

This study looked at 54 people with a specific type of kidney inflammation. It checked if biopsy results could predict how well they would do. This shows a link between the biopsy...

Selective Prescribing of First‐Line SGLT2 Inhibitor and GLP‐1 RA in Adults With Severe Mental Illness and Type 2 Diabetes

Antidiabetic medications in the pipeline.

This review looks at new diabetes drugs being developed. It explains how these drugs target multiple body systems at once. It discusses how they might help with heart, kidney, and...

Glucagon-Like Peptide-1 Receptor Agonists and Multi-hormone Receptor Modulators for Kidney Protection in Nondiabetic Kidney Disease.

This review explains how certain diabetes drugs might protect the kidneys. It looks at people who do not have diabetes. It summarizes what is known about how these drugs work....

Key safety outcomes of SGLT2 inhibitors versus DPP-4 inhibitors in general and vulnerable participants with T2DM: A target trial emulation study.

This study compared two diabetes drugs in 224,510 people. It looked at safety issues, especially in older or frail patients. The study shows a link between the drugs and different...

Higher APOB is associated with poor renal outcome in lupus nephritis.

This study looked at 462 people with lupus nephritis, a type of kidney disease caused by lupus. It found that people with higher levels of a blood protein called APOB had worse...

Deletion of Nephrocystin-4 Exacerbates Kidney and Cardiac Function in Mice Cardiorenal Syndrome Model via the Interaction with Itch E3 ligase.

This study used mice to look at a gene called Nephrocystin-4. When the researchers removed this gene, the mice had worse heart and kidney function. The work was done in animals,...

A Multi-centre Trial to Assess the Efficacy and Safety of the Omnipod 5 System in People With Type 2 Diabetes Undergoing Haemodialysis

This is a new study that is starting. It will test an automated insulin pump for people with type 2 diabetes who are on dialysis. There are no results yet.

Biopsy-Proven Glomerular Diseases in Saudi Arabia: The Clinicopathological Spectrum and Predictors of Renal Outcomes in a Single-Center Cohort and Four Decades of National Data.

This study reviewed kidney biopsies from a single center in Saudi Arabia over 24 years. It looked at what types of disease were found and what factors were linked to a drop in...

Comparative Profiling of Arterial Stiffness and Radiocephalic Arteriovenous Fistula Morphology in Diabetic Versus Non-Diabetic Patients on Maintenance Hemodialysis

This study looked at 120 people on dialysis to see if diabetes changes their blood vessels. It found that diabetes is linked to stiffer arteries. Stiff arteries can raise blood...

Association between atherogenic index of plasma and kidney stones: a case-control study in Chinese adults

Evaluating Darbepoetin Treatment Strategies for Managing Anaemia in Haemodialysis Patients: Effects on All‐Cause Mortality From a Target Trial Emulation Using Electronic Health Record Data

This study used records from UK dialysis centers to test different blood count targets. It found that aiming for higher blood counts did not lower death rates. This is an...

The role of finerenone in combination with sodium-glucose cotransporter-2 inhibitors in preventing and/or delaying the progression of diabetic kidney disease in individuals with type 2 diabetes: a scoping review

This review is mapping out what we know about using two diabetes drugs together. It aims to see if they help slow kidney decline. The review is still in progress, so there are no...

Risks of chronic kidney disease progression in patients with acute decompensated heart failure complicated by severe edema

This study followed 95 people with heart failure and kidney disease. It looked at how their kidney function changed during a hospital stay. It shows a link between heart failure...

Retinal Disease Risk With Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors Versus Long-Acting Erythropoiesis-Stimulating Agents in Patients With Non-Dialysis Chronic Kidney Disease: A Real-World Database Analysis in Japan.

This study looked at records of people in Japan with kidney disease who took new oral anemia drugs. It compared them to people who took older anemia shots. It shows a link between...

Interventions targeting cardiometabolic non-communicable diseases (NCDs) in pregnancy in low- and middle-income countries (LMICs); a systematic review with focus on complex interventions

This is a review of programs that help pregnant women manage diabetes and high blood pressure in poorer countries. It looks at how these programs work. It does not report new...

Emerging Role of Nailfold Capillaroscopy in Assessment of Microvascular Affection in Patients with Systemic lupus erythematosus

This paper discusses using a camera to look at tiny blood vessels in the nails of people with lupus. It is a review of the method. It does not report new clinical trial results.

The Association of Metoprolol Use With Outcomes in Heart Failure With Preserved Ejection Fraction (HFpEF): A Propensity Score-Matched Cohort Study

This study looked at records of people with a specific type of heart failure. It compared those who took metoprolol to those who did not. It shows a link between the drug and...

Histologically confirmed sodium polystyrene sulfonate-associated small bowel ischaemia after redo valve surgery

This is a report on one patient who had a rare bowel injury after taking a potassium binder. The patient had kidney disease and heart surgery. It is a single case, not a large...

Necrosis avascular bilateral de la cabeza del fémur

This report describes one man with kidney failure on dialysis. He developed bone death in both hips. The doctors think his kidney disease caused it. This is a single case, not a...

Chronic kidney disease as a systemic disorder: filtration phenotypes, inflammation and cardiovascular risk in the cardio-kidney metabolic era.

This review explains how kidney disease affects the whole body. It links kidney function to heart health and inflammation. It does not report new trial results. It helps doctors...

Laparoscopic Renal Denervation and Perirenal Adipose Tissue Debulking for Refractory Hypertension in End-Stage Renal Disease.

This is a case report about one man on dialysis who had a new nerve-blocking surgery. His blood pressure dropped significantly after the procedure. It is a single patient story, so...

Baseline and longitudinal determinants of survival in end-stage renal disease: A joint longitudinal-survival analysis.

This study looked at 330 people on dialysis in Iran. It found that tracking blood markers over time helps predict who will survive. This shows a link between these markers and...

Drug–Drug Interactions vs. Therapeutic Combinations in Patients with Congestive Heart Failure and Diabetes: An Ambispective Real‐World Study

Health technology assessment of long-acting erythropoiesis-stimulating agents for the treatment of renal anemia in China

Exacerbation of Pre-existing Hypothyroidism Following Enarodustat Administration in a Patient on Peritoneal Dialysis: A Case Report

Development and validation of an interpretable prediction model for high-grade vesicoureteral reflux in children with urinary tract infections

This research builds a tool to predict a urine flow problem in children. It focuses on kids who have urinary tract infections. There is no abstract, so we do not have the results...

Contrast-enhanced voiding urosonography - urodynamics in patients with neurogenic bladder dysfunction: a pilot study within pediatric urological practice

This pilot study tests a special ultrasound for bladder issues in children. It looks at kids whose nerves do not control the bladder well. There is no abstract, so we do not have...

Acute Urinary Retention Leading to Post-renal Acute Kidney Injury Post-radiotherapy: A Case Report

This is a report on one person who could not pee after radiation. This blocked urine flow and caused sudden kidney injury. There is no abstract, so we do not have the results yet.

Hidden Monogenic Diagnoses in Young-Onset Dialysis After Exclusion of Clinically Apparent Polycystic Kidney Disease

This preprint looks at 108 people who started dialysis before age 50. It found that some had hidden genetic causes for their kidney failure. This is a review of genetic data, not a...

Diagnostic challenges of masked arginine vasopressin deficiency in neurosarcoidosis complicated by sodium–glucose cotransporter 2 inhibitor use

This is a case report about one patient with a rare condition. It describes a tricky diagnosis, but it does not provide new results for a large group of people.

Differences in urinary biomarker profiles in patients with nephrotic-range proteinuria with and without hypoalbuminemia: a single-center cross-sectional study

This study looks at urine markers in people with high protein levels. It compares those with and without low blood protein. There is no abstract, so the results are not available...

Phase 1, open-label, randomized study of the elecoglipron pharmacokinetic profile in healthy participants under fed and fasted conditions.

This small trial tested a new diabetes drug in 14 healthy people. It measured how the drug moved through the body after eating or fasting. The study was short, lasting only a few...

Prognostic Value of Sudomotor Small-Fiber Function and Large Nerves for Accelerated Renal Decline in Type 2 Diabetes: A Real-World Cohort Study.

This study looked at people with type 2 diabetes. It found that nerve damage was linked to a faster drop in kidney function. This is an observational study, so it shows a link...

Effects of muscle strength training with blood flow restriction on glomerular function in people with stage 3 chronic kidney disease.

This trial tested if strength training with blood flow restriction helps people with stage 3 kidney disease. The study included 40 people who trained for 12 weeks. It looked at...

Effectiveness of a self-management intervention on clinical outcomes among patients with type 2 diabetes at high risk for Diabetic Kidney Disease: A Randomised Controlled Trial.

This trial tested a self-care program for people with type 2 diabetes who are at high risk for kidney disease. The program helped improve clinical outcomes compared to standard...

Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years

This is a new study that is starting. It will look at the link between high body weight and gum disease in Thai adults. There are no results yet.

Nutritional Status in Patients With Chronic Kidney Disease Receiving 7.2% Amino Acids During Hemodialysis

This is a new study that is starting. It will look at how a protein drink given during dialysis affects nutrition in people with kidney disease. There are no results yet.

How does educating patients with chronic kidney disease about their condition improve adherence to treatment plans and lifestyle modifications?

This is a review of existing research on patient education. It suggests that teaching patients about their condition helps them follow treatment plans. There are no new results in...

Epimeric Vitamin D is Not Associated With Arterial Stiffness or Cardiovascular Outcomes in Patients With Advanced CKD.

Researchers checked if a specific form of vitamin D was linked to stiff arteries in 270 people with advanced kidney disease. They found no link between this vitamin form and heart...

Associations of access to exercise opportunities and physical inactivity with cardiovascular–kidney–metabolic mortality: a nationwide ecological study

Optimal exercise modalities and doses for blood pressure management in adults with prehypertension and hypertension: A systematic review and Bayesian network meta-analysis.

This large review looked at 284 studies on exercise and blood pressure. It found that certain types of workouts lower blood pressure the most. This helps doctors pick the best...

Metabolic Control and the Symptoms/Problems Domain of Kidney Disease-Specific Quality of Life in Patients Receiving Kidney Replacement Therapy

This preprint looks at how well people on dialysis control their metabolic markers. It is an observational study, so it shows a link, not proof of cause. The goal is to see if...

The Effect of Mobile Health Psychoeducational Program on Depressive Symptoms and Coping Strategies among Patients Undergoing Hemodialysis

This is a study about a phone-based program to help people on dialysis manage their mood. The full details are not available, so there are no results to report.

Temporal-Experiential Model of Progressive Illness and Unified Self (TEMPUS): Rethinking Psychopathology in Chronic Disease Through Narrative Identity and Self-Coherence / Modelo temporal-experiencial de la enfermedad progresiva y el yo unificado (TEMPUS): un nuevo enfoque de la psicopatología en las enfermedades crónicas a través de la identidad narrativa y la coherencia del yo

This paper introduces a new theory about how people cope with chronic illness. It focuses on how disease changes a person's sense of self. It is a theoretical model, not a clinical...

Religiosity and spirituality as stressors or stress relievers in relation to sleep health among African American women.

This survey of 1,693 Black women found a link between faith and sleep quality. It shows a connection, not proof of cause. The study did not focus on kidney disease.

Longitudinal associations between loneliness and outcomes of Common Mental Disorders (CMDs): A systematic review and meta-analysis.

This review looked at many studies to see if loneliness predicts worse mental health. It found a link between feeling lonely and having common mental disorders. This shows a...

Effects of yoga-based and conventional physiotherapy programs on functional, respiratory, and psychosocial outcomes in stage II sarcoidosis: A randomized controlled trial.

This trial compared yoga and standard physical therapy for people with sarcoidosis. Sarcoidosis is a disease that causes inflammation in the body. The study used a remote delivery...

Mesenchymal stem cells in diabetic kidney disease: Potential regulatory mechanisms and related signaling pathways of mesenchymal stem cells.

This is a review of past studies on stem cells for diabetic kidney disease. It discusses how these cells might help, but it does not report new trial results. It is a summary of...

FDG-PET in Infection Imaging of Immuno-compromised Patients.

This review looks at how a special scan called FDG-PET helps find infections. It focuses on people with weak immune systems, including those on dialysis. The scan can find...

Implementation of a multi-disciplinary hemodialysis access clinic improves time to surgical evaluation and access case volume.

A hospital started a new clinic to help people get ready for dialysis. The clinic helped doctors see patients faster. It also increased the number of dialysis access surgeries...

Disease-associated amino acid substitutions outside canonical motor motifs impair Myo1e localization and activity

This study looked at a protein called Myo1e in cells. It found that two specific changes in the protein's structure can break how it works. This is a preclinical study in cells,...

Vascular Plug Closure of Delayed Leaflet Perforation Post-TEER in Patient With Multiple Implantable Devices.

This is a case report about one man on dialysis who had a heart valve repair. He developed a hole in the valve later, which was fixed with a plug. It is a single patient story, so...

Severe Bioprosthetic Mitral Valve Dysfunction: Multimodality Imaging Identifies Structural Valve Degeneration and Guides Valve-in-Valve TMVR.

This is a case report about one patient on dialysis who had a failing heart valve. Doctors used special imaging to find the problem and guide a new valve repair. It is a single...

Thrombus burden-stratified catheter-directed thrombolysis combined with percutaneous transluminal angioplasty for acute arteriovenous graft thrombosis in hemodialysis patients: a comparison of single-session versus extended infusion protocols

This study looks at how to clear blood clots in dialysis tubes. It compares two different ways to give the clot-busting medicine. There is no abstract, so we do not have the...

A Human Precision Cut Kidney Slice Platform for Studying Glomerular Biology and Therapeutic Responses

This preprint describes a new way to study tiny slices of human kidney tissue in the lab. It is a tool for research, not a treatment for people yet. It helps scientists see how...

Profound Tacrolimus-Induced Catatonic Encephalopathy in a Kidney Transplant Recipient With Mitochondrial Myopathy: A Cautionary Case of Reversible Neurotoxicity.

This is a report on one patient who had a kidney transplant. The patient had a rare genetic condition and a severe brain reaction to a drug. The brain issues went away after the...

Successful Second Kidney Transplantation Using a Living Donor Kidney with Complex Vascular and Urological Anatomy–A Case Report

This is a report on one specific patient. It describes a successful second kidney transplant using a donor kidney with unusual blood vessels. It is a single case, not a large...

https://www.theisn.org/blog/event/isn-transplantation-working-group-webinar-kidney-transplantation-at-scale-from-clinical-care-to-education-and-research/

This is an announcement for a webinar on kidney transplants. It will cover care, education, and research. There are no new study results in this post.

An application of the Theory of Planned Behavior within a living organ donation education intervention for American Muslim communities: a pre–post evaluation

This study looks at how to teach organ donation to American Muslim communities. It uses a theory of planned behavior to guide the education. There is no abstract, so we do not have...

Single-cell profiling of peripheral immune remodeling in BK polyomavirus–associated nephropathy after kidney transplantation

What are the key knowledge gaps primary care clinicians have regarding the management of chronic kidney disease (CKD)?

This is a review of research on doctor training. It found that many primary care doctors have gaps in their knowledge of kidney disease. There are no new results in this specific...

How effective are educational interventions in improving primary care clinicians' understanding and management of chronic kidney disease?

This is a review of research on doctor training. It suggests that education helps doctors manage kidney disease better. There are no new results in this specific document.

Prognostic Impact of Baseline Renal Dysfunction on Survival in Multiple Myeloma: A Retrospective Cohort Study

This study looked at 88 people with a blood cancer called multiple myeloma. It checked if having weak kidneys at the start affected how long they lived. The study shows a link...

Occult disseminated Nocardia farcinica infection with subsequent ANCA-negative crescentic glomerulonephritis: a diagnostic challenge—a case report

This is a report on one person who had a rare infection that caused kidney inflammation. It describes how hard it was to find the cause. There are no new results or treatments from...

Dermatological Manifestations in Patients with Chronic Kidney Disease

This study compared 47 people with kidney disease to 47 healthy people. It looked at skin, hair, and nail changes. It shows a link between kidney disease and these physical signs,...

Analysis code for temperature attributable chronic kidney disease mortality among older adults in China using GBD 2023

This is a set of computer code used to analyze data on kidney deaths in China. It looks at how temperature might affect older adults. There are no new medical results here, just...

Peritoneal Dialysis versus Conventional Hemodialysis and Serum TNF-α, CRP, and IL-6 Levels in Patients with End-Stage Renal Disease: A Systematic Review and Meta-Analysis

This review combined data from 22 trials involving 1,838 people on dialysis. It found that peritoneal dialysis was linked to lower levels of body inflammation markers than standard...

What are the most common concerns and challenges faced by patients with chronic kidney disease from their own perspective?

This item summarizes the main worries of people with kidney disease. It covers symptoms, feelings, money, and talking to doctors. It is a general overview of patient experiences,...

Burden of care, psychological distress, resilience and quality of life in caregivers of patients with renal disease

This study surveyed 300 caregivers of people with kidney disease. It measured their stress, resilience, and quality of life. It shows a link between caring for a sick relative and...

Indonesia Cardiometabolic Disease: An Epidemiologic Diagnostic

This report tracks heart, diabetes, and kidney disease in Indonesia. It looks at national trends and care pathways. It is a broad overview of health data, not a specific clinical...

Kidney Disease in the News 2019–2026: article-level dataset and coverage tables

This is a large data set of news articles about kidney disease. It covers reports from 2019 to 2026. It tracks how the media talks about the condition, but it does not report new...

Prevalence and Correlates of Depression in Patients With Chronic Kidney Disease Undergoing Maintenance Hemodialysis at a Tertiary Care Center in Kerala

This article is about depression in people on dialysis. However, the text provided has no abstract or details. We cannot confirm the specific results or study size from this...

Resolution of Proteinuria After Renal AVM Embolization with Combined ACEi and SGLT2i Therapy: A Case Report

This is a report about one person's medical case. It describes a treatment for a rare blood vessel issue in the kidney. There are no results to share yet because the full details...

Kidney Disease in the News, 2019–2026: Attention, Geography and Tone of Global Coverage, and How It Compares with Research and Invention

This study looks at how news outlets covered kidney disease from 2019 to 2026. It compares news stories to scientific papers and patents. It is a data analysis, not a medical...

Assisted peritoneal dialysis in older adults: a systematic review of peritonitis, technique survival and quality of life

This is a review of studies on dialysis for older adults. The team is still gathering and checking the papers. There are no final results to report yet.

Preoperative Glucose-to-Albumin Ratio and Postoperative Acute Kidney Injury in Patients Admitted to the Cardiac Surgery Recovery Unit: Association Analyses and Interpretable Machine Learning Based on the MIMIC-IV Database

This is a preprint about using computer models to predict kidney injury after heart surgery. It has not been checked by other experts yet. There are no results to report.

Clinical Outcomes of Early- versus Late-Onset Sepsis-Associated Acute Kidney Injury in Patients with Septic Shock: A Retrospective Cohort Study

This is a preprint about kidney injury caused by a severe infection. It compares when the injury started. It has not been checked by other experts yet, so there are no results.

Diabetes-Related Complications and Quality of Life Among Older Adults with Type 2 Diabetes Mellitus: A Scoping Review of Complication-Specific and Generic Measurement Approaches

This review is mapping how diabetes complications affect quality of life in older adults. It is still in the planning stage. There are no results to report yet.

Severe Influenza A-Associated Rhabdomyolysis Without Acute Kidney Injury: A Case Report

This is a report about one person who had a muscle breakdown from the flu. It is a single case, not a large study. There are no results to report.

INJÚRIA RENAL AGUDA NO PACIENTE INTERNADO: CAUSAS EVITÁVEIS E CRITÉRIOS DE DIÁLISE

This is a book chapter on how to prevent and treat sudden kidney injury in the hospital. It covers how to spot the problem and when to start dialysis. There are no new study...

What is the level of understanding of CKD regarding diagnosis and early-stage management among primary care clinicians?

This paper looks at how well primary care doctors understand early kidney disease. It suggests that better training could help them manage patients. There are no new clinical trial...

Chronic Kidney Disease Burden Attributable to Metabolic Risks Among Women Aged ≥55 Years Worldwide, 1990–2021: A Global Burden of Disease Study 2021 Analysis

This report uses global data to show how much kidney disease in older women is caused by metabolic risks. It looks at trends from 1990 to 2021. It is a data analysis, not a...