← brief for 2026-10-19 · Slowing decline

Deletion of Nephrocystin-4 Exacerbates Kidney and Cardiac Function in Mice Cardiorenal Syndrome Model via the Interaction with Itch E3 ligase.

Key takeaways

This study used mice to look at a gene called Nephrocystin-4. When the researchers removed this gene, the mice had worse heart and kidney function. The work was done in animals, not people, so it is not yet a treatment option. It helps explain how the heart and kidneys affect each other.

Who did this work

Otaki Y (Yamagata University School of Medicine, Yamagata, Japan.) · Sato J (Yamagata University School of Medicine, Yamagata, Japan.) · Watanabe T (Yamagata University School of Medicine, Yamagata, Japan.) · Takehara T (Yamagata University School of Medicine, Yamagata, Japan.) · Kuramasu Y (Yamagata University School of Medicine, Yamagata, Japan.) · Yamaguchi R (Yamagata University School of Medicine, Yamagata, Japan.) · Ono H (Yamagata University School of Medicine, Yamagata, Japan.) · Tachibana S (Yamagata University School of Medicine, Yamagata, Japan.) · Goto J (Yamagata University School of Medicine, Yamagata, Japan.) · Takahashi H (Yamagata University School of Medicine, Yamagata, Japan.) · Arimoto T (Yamagata University School of Medicine, Yamagata, Japan.) · Ichikawa K (Yamagata University School of Medicine, Yamagata, Japan.)

Source

Article · Europe PMC, CKD · 2026-10-14
https://doi.org/10.1042/cs20262448