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Disease-associated amino acid substitutions outside canonical motor motifs impair Myo1e localization and activity

Key takeaways

This study looked at a protein called Myo1e in cells. It found that two specific changes in the protein's structure can break how it works. This is a preclinical study in cells, not people yet. It helps explain a rare genetic form of kidney disease.

Source

Preprint · bioRxiv cell biology (kidney-filtered downstream) · 2026-10-19
https://www.biorxiv.org/content/10.64898/2026.10.15.759198v1?rss=1