← brief for 2026-11-04 · Regeneration & devices

An actionable GPCR restores phosphoinositide homeostasis and kidney function in Lowe syndrome.

Key takeaways

This study found a drug that helps fix a rare genetic kidney disease called Lowe syndrome. It worked in cells and animal models, but not in people yet. The drug is an oral pill that targets a specific receptor. This is a preclinical finding, so it is not ready for human trials.

Who did this work

Staiano L · Testa M · Vicinanza M · Cervellini F · Giaquinto L · Patanella L · Di Tullio G · Santoro M · Carissimo A · Giordano A · Genovese M · Galietta LJV

Source

Article · PubMed, organoids & devices · 2026 Nov 4
https://pubmed.ncbi.nlm.nih.gov/42977741/