← brief for 2026-11-02 · Slowing decline

Metabolic reprogramming modulates cardiomyocyte hypertrophy via GLS1 in chronic kidney disease in male mice

Article D Peer reviewed Preclinical

Key takeaways

This study looked at how kidney disease affects the heart in male mice. It found that kidney disease changes how heart cells use energy. This shift may cause the heart muscle to thicken. The work was done in animals, not people yet.

Who did this work

Linnan Bai (Sir Run Run Shaw Hospital) · Yi Wang (First Affiliated Hospital Zhejiang University) · Lei Zhou (Sir Run Run Shaw Hospital) · Fenfen Peng (Zhujiang Hospital) · Xiaojiang Zhan (First Affiliated Hospital of Nanchang University) · Lidan Hu (Children's Hospital of Zhejiang University) · Xiao Wang (Sir Run Run Shaw Hospital) · Ruipeng Wei (Sir Run Run Shaw Hospital) · Jianbo Qing (Sir Run Run Shaw Hospital) · Minchao KANG (Sir Run Run Shaw Hospital) · Xinni Wang (Sir Run Run Shaw Hospital) · Yiting Zhao (Sir Run Run Shaw Hospital)

Source

Article · OpenAlex, CKD works · 2026-11-01
https://doi.org/10.1038/s41467-026-79129-w