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Changes of serum fibroblast growth factor 23 (FGF23) and Klotho in diabetic kidney disease and their correlation with coronary artery calcification: a retrospective study.

Article C Peer reviewed Observational

Key takeaways

This study looked at 176 people with diabetic kidney disease and 160 controls. It found that higher levels of FGF23 and lower levels of Klotho were linked to more calcium buildup in heart arteries. This shows a link, not proof of cause, between these kidney markers and heart health.

Who did this work

Hong Y (Department of Nephrology, Jiangnan University Medical Center, Wuxi, Jiangsu, China.) · Wang J (Department of Nephrology, Jiangnan University Medical Center, Wuxi, Jiangsu, China.) · Lu Q (Department of Nephrology, Jiangnan University Medical Center, Wuxi, Jiangsu, China.) · Sun W (Department of Nephrology, Jiangnan University Medical Center, Wuxi, Jiangsu, China.) · Sun J (Department of Nephrology, Jiangnan University Medical Center, Wuxi, Jiangsu, China.)

Source

Article · Europe PMC, CKD · 2026-10-20
https://doi.org/10.20945/2359-4292-2026-0125