Kidney research, 2026-10-24
Today’s kidney research digest
A new review found that high-intensity interval training is the best type of exercise for lowering blood fats. Other studies looked at kidney transplant care, bone loss, and a rare case of kidney damage from leukemia.
Research trends and emerging topics in gut microbiota-derived metabolites and diabetic kidney disease: a multi-database bibliometric analysis (2014–2025)
This paper maps out research trends on gut bacteria and kidney disease. It looks at how these topics have grown over time. It is a map of the field, not a new clinical trial. There...
Periostin in diabetic kidney disease: mechanistic insights, biomarkers, and therapeutic perspectives
This review looks at a protein called periostin. It is linked to kidney damage in people with diabetes. The article discusses how this protein works and how it might be used as a...
Dynamic risk assessment by landmark modeling of the restricted residual mean survival time.
This paper describes a new math method for predicting patient risk. It helps doctors make better treatment choices over time. It is a method paper, so it does not report results...
Acute Kidney Injury Among Patients with Drug Overdose-Involved Hospitalizations - United States, 2016-2025.
This report looked at hospital records from 2016 to 2025. It found that 34.5% of people admitted for a drug overdose also had acute kidney injury. That is a sudden, serious drop in...
Echinacoside attenuates unilateral ureteral obstruction-induced renal fibrosis through NGF/PI3K/PKCδ/Src signaling.
Researchers tested a plant compound called echinacoside in mice. They blocked the mice's urine flow to cause kidney scarring. The compound helped reduce that scarring. This was...
Renal Safety and Antiviral Effectiveness of Tenofovir Alafenamide Versus Entecavir in Patients With Chronic Hepatitis B and Chronic Kidney Disease: A Real‐World Cohort Study
This study compared two hepatitis B drugs in 54 people who already had kidney disease. It looked at kidney function over 48 weeks. The results show a link between the drugs and...
Exosomal C3a initiates the NF-κB-dependent inflammatory axis in IgA nephropathy: a three-phase pilot study integrating clinical, in vivo, and in vitro evidence
This study looks at a specific protein involved in kidney inflammation. It aims to understand how this protein drives damage in a condition called IgA nephropathy. There are no...
An individual sample predictive model to classify patients with metastatic renal cell carcinoma
This study builds a model to predict how kidney cancer might spread. It focuses on a specific type of kidney cancer that has already moved to other parts of the body. There are no...
Combined and simultaneous use of Nefecon and irbesartan in treatment-naïve primary IgA nephropathy
Twelve people with a specific kidney disease took two drugs together for six months. This small study shows a link between the drug mix and changes in the body, but it is not proof...
Urinary amino acids patterns enlighten new predictive models for extensive renal proximal tubular injuries and kidney function
Researchers checked urine samples from 157 people with kidney damage. They found that certain chemicals in the urine can help predict how well the kidneys are working. This shows a...
Association of TLR8 Expression in Peripheral Blood Mononuclear Cells with Clinical and Histopathological Severity in IgA Nephropathy
This is a preprint that looks at a specific immune marker in blood. It aims to see if this marker matches the severity of kidney disease. There are no final results yet, as it has...
External validation of the renal angina index for early prediction of severe acute kidney injury in critically ill children: a prospective cohort study from Vietnam
This study tests a scoring tool to predict sudden kidney injury in children. It looks at how well this tool works in a hospital setting in Vietnam. There are no results to report...
Anticoagulation in advanced renal failure: do factor XI/XIa inhibitors represent the long-awaited shift?
This article discusses new blood thinners for people with advanced kidney failure. It explains why current drugs are hard to use in this group. There are no new trial results in...
SOD Polymorphisms and the Klotho–FGF-23 Axis in Heart Failure-Associated Kidney Disease: A Narrative Review
This review looks at how two body systems, antioxidant defense and a hormone axis, might work together to cause kidney damage in heart failure. It discusses these ideas but does...
Effects of Drugs with Different Mechanisms of Action on Kidney Function Decline in Patients with IgA Nephropathy: A Systematic Review and Meta-analysis of Total and Chronic eGFR Slopes
This project plans to review how different drugs affect kidney decline in people with IgA nephropathy. It is a study that is starting, and there are no results yet.
Serum levels of IL-6, TNF-α, and IL-10 in patients with chronic kidney disease: A comparative study of pre- and post-dialysis concentrations
This study compares inflammation markers in the blood before and after dialysis. It reports on these levels, but the abstract does not give specific numbers or final conclusions.
Longitudinal albumin and blood pressure trajectories identify mortality risk phenotypes in hemodialysis
Researchers looked at 38,863 adults who started dialysis between 2010 and 2014. They tracked blood pressure and protein levels over time to find patterns. This shows a link between...
Microbiological patterns of bacterial bloodstream infections and predictors of kidney dysfunction at a tertiary hospital in Zambia.
This study looked at patients with blood infections at a hospital in Zambia. It found that certain lab results were linked to kidney damage. This shows a link, not proof of cause.
Monocyte-macrophage sensing of calciprotein particles in CKD-associated vascular calcification: lysosomal stress and inflammasome activation
This review explains how immune cells react to calcium particles in the blood of people with kidney disease. It discusses how this reaction may lead to hardening of the arteries....
Pauci-Immune crescentic glomerulonephritis in a patient initially considered to have diabetic kidney disease
This report describes one man whose kidney disease was first thought to be from diabetes. A biopsy later showed a different type of kidney inflammation. This is a single case...
Cardiovascular–kidney–metabolic syndrome: novel molecular mechanism and glucagon-like peptide-1-targeting therapy
This article explains how heart, kidney, and metabolic problems are linked. It discusses how certain drugs might help this group of conditions. It is a review of existing science,...
Comparison of eGFR equations for estimating renal function in Chinese children under 2 years: a retrospective study
This study looked at 76 children under age 2. It compared different math formulas used to estimate kidney function. It found that one specific formula worked best for this young...
Macrognathia Secondary to Renal Osteodystrophy in a Hemodialysis Patient: A Case Report and Literature Review
This report describes one woman on dialysis who developed jaw enlargement. This is a rare bone change caused by long-term kidney disease. It is a single case report, so it does not...
Multiple organ dysfunction syndrome in emergency cardiovascular patients with COVID-19: from clinico-laboratory markers to hospital outcomes
This study followed 139 people with heart issues and COVID-19. It looked at how many developed multiple organ failure. This is an observational study, so it shows a link, not proof...
Machine learning based predictive model for cardiovascular disease mortality risk in patients with stage 4 cardiovascular–kidney–metabolic syndrome
This study used computer models to predict heart disease risk in 2,893 patients. It found that the model could identify who was at higher risk. This is an observational study, so...
How to investigate abnormalities in selenium plasma concentrations in humans – Diagnostic algorithms
Renin-Angiotensin System (RAS) Inhibitors in High-Risk Patients With Type 2 Diabetes and Cardio-Renal Risk
This article discusses blood pressure drugs for people with diabetes and kidney risk. It is a review or discussion piece. There are no new results or data from a trial. It...
Effect of delayed remote ischemic preconditioning on major cardiovascular and cerebrovascular events in major vascular surgery: the protocol of DRIPC randomized controlled trial
This is a trial protocol for a study on a technique to protect the heart during surgery. It is a plan for a future study. There are no results yet. It describes how the trial will...
The BAFF/APRIL system in autoimmune nephropathy: from pathogenesis to targeted biologic therapies
This is a review of how the immune system causes kidney disease. It discusses new biologic therapies. There are no new results or data from a trial. It summarizes what is known...
Renal anemia: from erythropoietin deficiency to erythropoietin resistance
This review covers low blood cell counts in people with kidney disease. It discusses how the body makes red blood cells. There is no abstract, so no specific results are available...
Associations between a series of composite glucose-lipid indices and moderately increased albuminuria in patients with type 2 diabetes mellitus: a cross-sectional study
This study looks at blood sugar and fat levels in people with type 2 diabetes. It checks for protein in the urine. There is no abstract, so no specific results are available yet.
Amomum tsao-ko volatile oil alleviates renal fibrosis in 5/6 nephrectomy rats through TGF-β1/SMAD3 and PI3K/AKT signaling pathways
This study tested a plant oil in rats with kidney damage. It looked at how the oil affects scarring. There is no abstract, so no specific results are available yet.
Early Manifestations of Granulomatosis With Polyangiitis: A Case Report
This is a report on one person with a rare immune disease. The disease can affect the kidneys. There is no abstract, so no specific results are available yet.
Single-cell RNA sequencing highlights the heterogeneity of neutrophils in granulomatosis with polyangiitis
This study looks at immune cells in a rare disease. It uses a detailed lab test to see how the cells differ. There is no abstract, so no specific results are available yet.
Changes of serum fibroblast growth factor 23 (FGF23) and Klotho in diabetic kidney disease and their correlation with coronary artery calcification: a retrospective study.
This study looked at 176 people with diabetic kidney disease and 160 controls. It found that higher levels of FGF23 and lower levels of Klotho were linked to more calcium buildup...
Prevalence of sarcopenia in adults with chronic kidney disease on maintenance hemodialysis: protocol for an updated systematic review and meta-analysis (studies published from December 2022)
This is a plan for a review of existing studies. It aims to find out how common muscle loss is in people on dialysis. There are no results yet, as this is just the study protocol.
Association of Inflammation, Oxidative Stress and Dietary Inadequacy with Protein-Energy Wasting in Pre-Dialysis Chronic Kidney Disease
A study in India found that poor diet and body inflammation are linked to muscle loss in people with kidney disease. This shows a connection, but it is not proof that diet causes...
Efficacy and safety of a ceramide-based moisturizer for xerosis and chronic kidney disease associated pruritus in maintenance hemodialysis: a randomized controlled trial
People on dialysis who used a special skin cream had less dry, itchy skin. The study included 130 people and lasted 8 weeks. This is a small trial, so the results are promising but...
CYP1B1 is a potential target of kaempferol in renal fibrosis: a multi‑omics and single‑cell transcriptomics study.
This study looked at how a plant compound called kaempferol affects kidney scarring. It used computer models and cell data to find a target called CYP1B1. This was done in cells...
Anti-Calcification Effects of Immortalized Human Adipose Tissue-Derived Mesenchymal Stem/Stromal Cell (HATMSC2) Secretome in an In Vitro Model of Vascular Calcification
Researchers tested a fluid from stem cells in a lab dish to see if it stops artery hardening. The fluid reduced calcium buildup in the cells. This was done in a test tube, not in...
Bilateral peripheral CT venography for evaluating central venous lesions in dysfunctional arteriovenous fistulas: feasibility, safety, and radiation dose in hemodialysis patients.
This study looked at 46 dialysis patients with failing fistulas. It tested a CT scan method to check for vein blockages. The study shows the method is safe and effective. It helps...
Decoding Zmiz1: a key transcription coactivator in development and disease
This review discusses a protein called Zmiz1. It plays a role in how cells grow and change. There is no abstract, so no specific results are available yet.
IL-6 Blockade for Antibody-Mediated Transplant Rejection: What Does the Evidence Say?
This article reviews the use of a drug that blocks a specific immune signal. It looks at how this might help stop the body from rejecting a kidney transplant. There are no new...
Effect of Kidney Allocation Policy Changes and Organ Donor Hospital Geographic Location on Deceased Donor Kidney Nonuse
This study looked at data from 2010 to 2024. It found that the location of the donor hospital affects whether a kidney is used. This shows a link, not proof of cause.
Glycaemic screening before kidney transplantation should include an oral glucose tolerance test
This article discusses how to check for diabetes before a kidney transplant. It suggests using a specific blood sugar test. It is a review of current practices, not a new trial...
Comparative long-term outcomes of kidney transplantation from donors with isolated microscopic hematuria and thin basement membrane disease versus donors with isolated microscopic hematuria and normal histology: the largest cohort analysis to date
This study compares kidney transplants from donors with different types of urine protein. It is a large cohort analysis. There are no new results or data from a trial. It looks at...
Feasibility of a machine learning model for predicting weight gain after kidney transplantation machine learning and weight gain after kidney transplantation.
This study used a computer model to predict weight gain in 374 people after kidney transplant. It found that certain factors could help predict how much weight a person might gain....
Preferences for digital health services among patients with chronic kidney disease: a discrete choice experiment
This study asked kidney patients what they want from digital health tools. It used a method to rank their choices. The focus is on patient preferences, not on how to treat the...
Comparing hemolysis among extracorporeal pumps: A large-scale retrospective study
This study compared four types of heart-lung machines used in critical care. It looked at 230 patients to see which machines caused the most red blood cell breakdown. This...
When to stop kidney replacement therapy in critically ill children: current evidence and practical considerations from a pediatric critical care nephrology perspective
This is a review of current evidence on when to stop dialysis in sick children. It discusses the risks of stopping too early or too late. There are no new results in this paper, as...
Developing a pharmacy-led integrated primary care model for chronic kidney disease prevention in community pharmacy settings under Thailand’s Universal Health Coverage System: an action research
This study is about creating a new way for pharmacists in Thailand to help prevent kidney disease. It is an action research project that is still being developed. There are no...
Machine Learning and Reinforcement Learning for Chronic Kidney Disease Prediction: Research Code
This is a set of computer code used for a master's thesis. It tests how well computer programs can predict if someone has chronic kidney disease. There are no clinical results...
Circulating Glycocalyx Biomarkers and Acute Kidney Injury in Adults with Sepsis: A Scoping Review of Sampling Timing, Kidney Function, and Clinical Validation
This is a plan for a review of existing studies. It will look at blood markers for sudden kidney injury. There are no results yet.
redictive Modeling for Diabetic Complications Using Artificial Intelligence
This study used computer models to predict kidney and heart problems in people with diabetes. It used data from over 100,000 hospital visits. This shows a link, not proof of cause.
Highlights from ASCO 2026: focus on immuno-oncology in kidney cancer
This article summarizes new cancer drug data from a 2026 medical meeting. It focuses on immune therapy for kidney cancer. There are no new trial results in this piece.
Simulation in nephrology nursing education among students and healthcare professionals: a scoping review
This is a plan for a review of how nurses are trained. It will look at the use of practice simulations. There are no results yet.
PREVALENCE OF CKD-DATA SET
This is a data set on kidney disease in people with diabetes in Tanzania. It is a collection of numbers, not a study with results.
Contemporary Burden, Drivers, and Risk‐Factor Control Gaps Across Cardiovascular–Kidney–Metabolic Syndrome Stages in US Adults, 2021 to 2023
A large national survey of US adults found that many people with kidney disease have uncontrolled blood pressure and cholesterol. This shows a link between poor risk control and...
Association of socioeconomic status with kidney function decline and mortality among older Korean adults: a nationwide cohort study
This large study followed 784,224 older adults in Korea. It found that people with lower income had faster kidney decline and higher death rates. This shows a link, but it does not...