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Genipin exerts renoprotective effects in type 2 diabetic nephropathy by regulating macrophage metabolism and inflammation via the UCP2/SIRT3 axis

Preprint D Not peer reviewed Preclinical

Key takeaways

This study tested a compound called genipin in mice with diabetic kidney disease. It looked at how the compound affects immune cells in the kidney. The results suggest it may protect the kidney, but this was in animals, not people yet.

Who did this work

Zhang J · Wang Y · Wang D · Li R · Liu H · Chen Y · Wang J · Yuan Y · Yan X · Yan X · Su J · Zhou L

Source

Preprint · Europe PMC, CKD · 2026-10-11
https://doi.org/10.22541/authorea.15010236/v1