← brief for 2026-10-16 · Slowing decline

Aryl Hydrocarbon Receptor Deficiency Impairs Intestinal Barrier Development, While 2′-Fucosyllactose Reduces Paracellular Permeability in Caco-2 Cells

Article D Peer reviewed Preclinical

Key takeaways

Kidney disease can damage the gut lining, which leads to body-wide inflammation. This study used cells in a lab, not people. It found a milk sugar called 2'-fucosyllactose helped keep the gut barrier strong. This suggests a possible future treatment, but it is not tested in humans yet.

Who did this work

Avra Melina Madella (Utrecht University) · Carlon C. E. van Gerven (Utrecht University) · Elena Sendino Garví (Utrecht University) · Jeroen van Bergenhenegouwen (Nutricia Research (Netherlands)) · Johan Garssen (Utrecht University) · Rosalinde Masereeuw (Utrecht University) · Saskia Adriana Overbeek (Nutricia Research (Netherlands))

Source

Article · OpenAlex, CKD works · 2026-10-15
https://doi.org/10.3390/toxins18100451