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Mitochondrial YME1L restrains GRP75-dependent ISR activation to prevent podocyte senescence in Diabetic kidney disease

Article D Peer reviewed Preclinical

Key takeaways

This study looked at a protein called YME1L in cells and animals. It found that when this protein is missing, kidney cells age faster and get damaged. When the protein is restored, the cells stay healthier. This work was done in the lab and in animals, not in people yet.

Who did this work

Qianqian Yang · Yiyuan Zhang · Yaowu Zhang · Hui Zhang · Liqin Zhang · Xiaobo Zhang · Yong Xu · Qijing Wu

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-10-06
https://doi.org/10.2337/figshare.33740665