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Pan-Fibrotic Gene Expression Signature in Major Chronic Diseases by Integrative Bulk and Single-Cell Transcriptomic Analyses

Article C Peer reviewed Observational

Key takeaways

This study used computer models to find a pattern of genes. The pattern is linked to scarring in the liver, kidney, and heart. The researchers tested this pattern in many tissue samples. This is an observational study, so it shows a link, not proof of cause. It may help doctors predict scarring risk.

Who did this work

Mayra Alejandra Jaimes Campos (Mosaiques Diagnostics and Therapeutics (Germany)) · Rafael Stroggilos (Academy of Athens) · Joost P. Schanstra (413906) (Université Toulouse III - Paul Sabatier) · Antonia Vlahou (Academy of Athens) · Manon Brunet (Inserm) · Jean‐Christophe Jonas (UCLouvain) · Mohammed Bensellam (UCLouvain) · Harald Mischak (Mosaiques Diagnostics and Therapeutics (Germany)) · Agnieszka Latosińska (Mosaiques Diagnostics and Therapeutics (Germany))

Source

Article · OpenAlex, CKD works · 2026-09-30
https://doi.org/10.3390/ijms27198755